| Basic Information | |
|---|---|
| Species | Oryza sativa |
| Cazyme ID | LOC_Os07g40740.1 |
| Family | GH79 |
| Protein Properties | Length: 530 Molecular Weight: 56219.7 Isoelectric Point: 8.5578 |
| Chromosome | Chromosome/Scaffold: 7 Start: 24417383 End: 24419441 |
| Description | glucuronidase 2 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH79 | 47 | 521 | 0 |
| DDNFVCATLDWWPRDKCNYGMCPWYNASIINLDLNNTILNNAVKAFNSLRIRLGGSLQDQVTYKVGSNYGDCRSFQRDDGGLFGFTDGCLEMNRWDELNV FFKRTNTTVTFGLNALKGRRKAAGGKDTLYSGDWDARNALDLMRYTAGKGYRVESWELGNELSGSGVAARVAAAQYGRDVAVLRKAVERVYGGGGEVPKV LAPGGFYDGAWFSEMLRVSGRGAVDGVTHHIYNLGSGKDRDLARKMQDPGYLDQVEKTFRDMAATVRGSGPWSSPWVGESGGAYNSGGKGVSDRYVNGFW YLDQLGMSAAHGTRVYCRQALVGGNYCLLNTTTFVPNPDYYGALLWHRLMGPVVLKAATTAGGGGSPYLRSYAHCSREKPGVTVLLINLSNATAFDVSVA GGALGAAPCGGRREEYHLSPLGGDIRSQVVLLNGEALALGPGGEIPELRPAVVGDGCAAPLRVAARGIAFVRFTE | |||
| Full Sequence |
|---|
| Protein Sequence Length: 530 Download |
| MAAVLPLLAA ALLVLFSGLH PAASTAAAGG EAATVVVKAA AAVSRTDDNF VCATLDWWPR 60 DKCNYGMCPW YNASIINLDL NNTILNNAVK AFNSLRIRLG GSLQDQVTYK VGSNYGDCRS 120 FQRDDGGLFG FTDGCLEMNR WDELNVFFKR TNTTVTFGLN ALKGRRKAAG GKDTLYSGDW 180 DARNALDLMR YTAGKGYRVE SWELGNELSG SGVAARVAAA QYGRDVAVLR KAVERVYGGG 240 GEVPKVLAPG GFYDGAWFSE MLRVSGRGAV DGVTHHIYNL GSGKDRDLAR KMQDPGYLDQ 300 VEKTFRDMAA TVRGSGPWSS PWVGESGGAY NSGGKGVSDR YVNGFWYLDQ LGMSAAHGTR 360 VYCRQALVGG NYCLLNTTTF VPNPDYYGAL LWHRLMGPVV LKAATTAGGG GSPYLRSYAH 420 CSREKPGVTV LLINLSNATA FDVSVAGGAL GAAPCGGRRE EYHLSPLGGD IRSQVVLLNG 480 EALALGPGGE IPELRPAVVG DGCAAPLRVA ARGIAFVRFT EFKAPACAA* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 4.0e-143 | 46 | 352 | 307 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0005623 | cell |
| GO:0008152 | metabolic process |
| GO:0016020 | membrane |
| GO:0016787 | hydrolase activity |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | EAZ04591.1 | 0 | 1 | 529 | 1 | 529 | hypothetical protein OsI_26741 [Oryza sativa Indica Group] |
| GenBank | EEE67528.1 | 0 | 16 | 529 | 16 | 490 | hypothetical protein OsJ_24994 [Oryza sativa Japonica Group] |
| RefSeq | NP_001060182.1 | 0 | 1 | 529 | 1 | 529 | Os07g0598400 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | XP_002315010.1 | 0 | 25 | 528 | 18 | 518 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002512114.1 | 0 | 31 | 526 | 29 | 529 | Heparanase precursor, putative [Ricinus communis] |
