| Basic Information | |
|---|---|
| Species | Oryza sativa |
| Cazyme ID | LOC_Os12g38920.1 |
| Family | GH79 |
| Protein Properties | Length: 540 Molecular Weight: 59538.6 Isoelectric Point: 6.1795 |
| Chromosome | Chromosome/Scaffold: 12 Start: 23931315 End: 23935728 |
| Description | glucuronidase 2 |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
 | |||
| Family | Start | End | Evalue |
| GH79 | 40 | 532 | 0 |
| NEFICATIDWWPPEKCNYDQCPWGQASILNLDLTNPLLAKAIQAFSPLRIRLGGSLQDQVVYGTPNLGSPCTPFSKSSSGLFGFSQGCITMERWDAINKI FMDTGAVVTFGLNALQGRQQMGRGVWGGAWNSSNAREFMEYTVSMNYPIDSWEFGNELSGSGIGASVGAEQYGKDIIELKNIISQLYGNSRKPLVVAPGG FYDQKWYAQLLDISGPNVLDTMTHHIYNLGAGNDPQVANRILNPQYLSQSSDTFRDLQMTIQRHGPWSAPWVGEAGGAYNSGSRKVSNTFLNSFWYLDQL GQSAKYDTKVYCRQTLIGGNYGLLDTETFVPNPDYYSALLWHRLMGKGVISLDTSGSSYLRAYAHCGKQKGGVALLMLNLNKNMGFMVSVRNDLNINFRE MAGIKRDNSFVHGLKRTVSWVGSKASDGLEKREEYHLTPQDGNPFARTVLLNGAPLQLTGDGDIPSLPPVMVSVNSPIYVAPLSIAFVVFPDF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 540 Download |
| MRLWFLIPLL LCFPTLIRSE DYSDVTIVVR GAETIASTSN EFICATIDWW PPEKCNYDQC 60 PWGQASILNL DLTNPLLAKA IQAFSPLRIR LGGSLQDQVV YGTPNLGSPC TPFSKSSSGL 120 FGFSQGCITM ERWDAINKIF MDTGAVVTFG LNALQGRQQM GRGVWGGAWN SSNAREFMEY 180 TVSMNYPIDS WEFGNELSGS GIGASVGAEQ YGKDIIELKN IISQLYGNSR KPLVVAPGGF 240 YDQKWYAQLL DISGPNVLDT MTHHIYNLGA GNDPQVANRI LNPQYLSQSS DTFRDLQMTI 300 QRHGPWSAPW VGEAGGAYNS GSRKVSNTFL NSFWYLDQLG QSAKYDTKVY CRQTLIGGNY 360 GLLDTETFVP NPDYYSALLW HRLMGKGVIS LDTSGSSYLR AYAHCGKQKG GVALLMLNLN 420 KNMGFMVSVR NDLNINFREM AGIKRDNSFV HGLKRTVSWV GSKASDGLEK REEYHLTPQD 480 GNPFARTVLL NGAPLQLTGD GDIPSLPPVM VSVNSPIYVA PLSIAFVVFP DFEAEGCER* 540 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
 | ||||||||
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 24 | 340 | 318 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0005618 | cell wall |
| GO:0008152 | metabolic process |
| GO:0016020 | membrane |
| GO:0016787 | hydrolase activity |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACR10240.1 | 0 | 1 | 539 | 1 | 539 | heparanase [Oryza sativa Indica Group] |
| GenBank | EEC69565.1 | 0 | 1 | 539 | 671 | 1237 | hypothetical protein OsI_38868 [Oryza sativa Indica Group] |
| GenBank | EEE53489.1 | 0 | 1 | 539 | 1 | 567 | hypothetical protein OsJ_36644 [Oryza sativa Japonica Group] |
| RefSeq | NP_001067122.1 | 0 | 1 | 539 | 1 | 539 | Os12g0578400 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | XP_002442385.1 | 0 | 17 | 539 | 18 | 540 | hypothetical protein SORBIDRAFT_08g019250 [Sorghum bicolor] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.004 | 119 | 428 | 107 | 409 | A Chain A, Structure Of The Thermostable Gh51 Alpha-L-Arabinofuranosidase From Thermotoga Petrophila Rku-1 |
| PDB | 3vnz_A | 0.004 | 119 | 428 | 107 | 409 | A Chain A, Structure Of The Thermostable Gh51 Alpha-L-Arabinofuranosidase From Thermotoga Petrophila Rku-1 |
| PDB | 3vny_A | 0.004 | 119 | 428 | 107 | 409 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
