| Basic Information | |
|---|---|
| Species | Oryza sativa |
| Cazyme ID | LOC_Os12g39340.1 |
| Family | GT4 |
| Protein Properties | Length: 458 Molecular Weight: 51397.2 Isoelectric Point: 8.6832 |
| Chromosome | Chromosome/Scaffold: 12 Start: 24204768 End: 24208276 |
| Description | UDP-Glycosyltransferase superfamily protein |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GT4 | 262 | 426 | 1.4e-24 |
| TTPPILISVAQFRPEKAHGLQLEAFAIALKKLSPEFPKPKLQFVGSCRNKEDLERLQKLKDRSTELHIDELVEFHKDISYRDLVQLLGGAVAGLHSMTDE HFGISVVEYMAAGAIPIAHKSAGPMMDIVLDEDGQQTGFLASEKEEYAEAIVKVLRMPEAERHEM | |||
| Full Sequence |
|---|
| Protein Sequence Length: 458 Download |
| MAFLAGLAAL LAALLAAAFR RIRRHPHPAP AAGFFHPYTN DGGGGERVLW CAVRAAQELR 60 PGLPCAVFTG DADASPDGLA ARALDRFGVR LLRPPQVVHL NRRKWIEAST YPHFTMIGQS 120 LGSVYLAWEA LNKFTPQFYF DTSGYAFTYP LARLFGCKVI CYTHYPTISS DMVERVKQRS 180 SMYNNDSRIA GSIWLSRCKI LYYSIFSWLY GLVGSCAHLV MVNSSWTRSH IENIWRIPER 240 TRRVYPPCDT SALQMLPLER STTPPILISV AQFRPEKAHG LQLEAFAIAL KKLSPEFPKP 300 KLQFVGSCRN KEDLERLQKL KDRSTELHID ELVEFHKDIS YRDLVQLLGG AVAGLHSMTD 360 EHFGISVVEY MAAGAIPIAH KSAGPMMDIV LDEDGQQTGF LASEKEEYAE AIVKVLRMPE 420 AERHEMATAA RKRAQRFSEH RFHEDFTDAV RPILSAT* 480 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam00534 | Glycos_transf_1 | 9.0e-23 | 263 | 433 | 173 | + Glycosyl transferases group 1. Mutations in this domain of human PIGA lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family. | ||
| cd03801 | GT1_YqgM_like | 7.0e-23 | 194 | 451 | 268 | + This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea. | ||
| cd03805 | GT1_ALG2_like | 1.0e-31 | 105 | 442 | 354 | + This family is most closely related to the GT1 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans. | ||
| PLN02949 | PLN02949 | 0 | 38 | 456 | 419 | + transferase, transferring glycosyl groups | ||
| cd03806 | GT1_ALG11_like | 0 | 38 | 445 | 411 | + This family is most closely related to the GT1 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown to block the early steps of core biosynthesis that takes place on the cytoplasmic face of the ER and lead to a defect in the assembly of lipid-linked oligosaccharides. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0005783 | endoplasmic reticulum |
| GO:0005975 | carbohydrate metabolic process |
| GO:0006464 | cellular protein modification process |
| GO:0006950 | response to stress |
| GO:0008152 | metabolic process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ABA99697.1 | 0 | 1 | 457 | 1 | 457 | glycosyl transferase, group 1 family protein, expressed [Oryza sativa (japonica cultivar-group)] |
| GenBank | EAY83676.1 | 0 | 116 | 457 | 1 | 342 | hypothetical protein OsI_38900 [Oryza sativa Indica Group] |
| GenBank | EAZ21019.1 | 0 | 25 | 457 | 25 | 413 | hypothetical protein OsJ_36668 [Oryza sativa Japonica Group] |
| RefSeq | NP_001142345.1 | 0 | 27 | 456 | 28 | 457 | hypothetical protein LOC100274516 [Zea mays] |
| RefSeq | XP_002443441.1 | 0 | 29 | 456 | 30 | 457 | hypothetical protein SORBIDRAFT_08g019540 [Sorghum bicolor] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2f9f_A | 0.00001 | 268 | 432 | 27 | 176 | A Chain A, Crystal Structure Of The Putative Mannosyl Transferase (Wbaz-1)from Archaeoglobus Fulgidus, Northeast Structural Genomics Target Gr29a |
| PDB | 2bfw_A | 0.0003 | 361 | 438 | 126 | 200 | A Chain A, Structure Of The C Domain Of Glycogen Synthase From Pyrococcus Abyssi |
| PDB | 2bis_C | 0.0004 | 361 | 449 | 342 | 427 | A Chain A, Structure Of Glycogen Synthase From Pyrococcus Abyssi |
| PDB | 2bis_B | 0.0004 | 361 | 449 | 342 | 427 | A Chain A, Structure Of Glycogen Synthase From Pyrococcus Abyssi |
| PDB | 2bis_A | 0.0004 | 361 | 449 | 342 | 427 | A Chain A, Structure Of Glycogen Synthase From Pyrococcus Abyssi |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| dolichyl-diphosphooligosaccharide biosynthesis | RXN-5464 | EC-2.4.1.131 | GDP-Man:Man3GlcNAc2-PP-Dol α-1,2-mannosyltransferase |
