Basic Information | |
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Species | Linum usitatissimum |
Cazyme ID | Lus10001952 |
Family | GH79 |
Protein Properties | Length: 328 Molecular Weight: 35504.1 Isoelectric Point: 7.831 |
Chromosome | Chromosome/Scaffold: 1801 Start: 80062 End: 84919 |
Description | glucuronidase 3 |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 79 | 320 | 6.2e-32 |
SSPFSGLQGVLNNAGSPAVAWVGEAGGAYNSTGRNLVTNAFVFSFWYLDQLARNGCCIIRHQNLQPAIISRRQLWPSRHNHLCPQPRLLYIGELTLQPCN FEISFSSTYSVFCLCPLLTSALLWHHLMGRSVLPVSFSGTKQIRAYVHCSKTSQGITLLLINLDSNATVSIRVSNKDVVPSPTAVKHYQSRKKNFARMGR SGSKMDVDTVSETISQLEPVQVGLLDPITIAPFSTLFVCIAN |
Full Sequence |
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Protein Sequence Length: 328 Download |
METVLCSGNV VPARNLCSAV EAIILETAVA AAGSLLCSLL MVDLLSAIVF PLYLQFILAS 60 AYFTVPFDNP GSEDLDGDSS PFSGLQGVLN NAGSPAVAWV GEAGGAYNST GRNLVTNAFV 120 FSFWYLDQLA RNGCCIIRHQ NLQPAIISRR QLWPSRHNHL CPQPRLLYIG ELTLQPCNFE 180 ISFSSTYSVF CLCPLLTSAL LWHHLMGRSV LPVSFSGTKQ IRAYVHCSKT SQGITLLLIN 240 LDSNATVSIR VSNKDVVPSP TAVKHYQSRK KNFARMGRSG SKMDVDTVSE TISQLEPVQV 300 GLLDPITIAP FSTLFVCIAN MTIPACK* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 1.0e-22 | 75 | 129 | 55 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI25561.1 | 4.2039e-45 | 75 | 327 | 291 | 533 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002283254.1 | 0 | 75 | 326 | 299 | 536 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002283260.1 | 0 | 75 | 327 | 299 | 546 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002324878.1 | 0 | 75 | 326 | 260 | 504 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002515478.1 | 0 | 75 | 326 | 274 | 522 | heparanase, putative [Ricinus communis] |