Basic Information | |
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Species | Linum usitatissimum |
Cazyme ID | Lus10004664 |
Family | GH79 |
Protein Properties | Length: 528 Molecular Weight: 58284.1 Isoelectric Point: 8.2444 |
Chromosome | Chromosome/Scaffold: 183 Start: 192503 End: 194962 |
Description | glucuronidase 2 |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 45 | 522 | 0 |
SDFICATIDWWPKNKCDYGQCPWGNNGAINLDLKNKNLQTAVKAFDPLRIRVGGSIEDLVVYKVGRAIKHFPKFKKQKNGLFGFSRGTLTMKRWDHLNAF FNKTNTKLIFGLNELVGKRNKDPSTLLWIGDWDARNARDLMSYTAHEGYKIDSYELGNELTGEGVSATIDPEQYAMDTKQLREAVNELYPDPSSRPKVLG PAGFFDKEWFKKYLQALGPNVVDGVTHHIYNLGAGVDPTLINKVQDPFFLDKIAQTFKDVRDIVDRSGTGASAWVGESGGAYNSGGKTVSHTFANGFWYL DQLGMTSTFNHKVYCRQSLVGGNYGFLKSRSFTPNPDYYGALLWHRLMGNGVLATSHDGSPYLRTYTHCSKNTTGVTMLLINMSNSTKFDIWISNDLNLY DLGSSSDSSFFLLTEDREEYHLTPKGGNIQSDVVLLNGTPLKLTKSGEIPKLAPKLVPASSPVTVAPDSFVYVTIKDF |
Full Sequence |
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Protein Sequence Length: 528 Download |
MAGLRALLLC SIFLAASSSF SLYIAATESV TVSVKSVTTI AETDSDFICA TIDWWPKNKC 60 DYGQCPWGNN GAINLDLKNK NLQTAVKAFD PLRIRVGGSI EDLVVYKVGR AIKHFPKFKK 120 QKNGLFGFSR GTLTMKRWDH LNAFFNKTNT KLIFGLNELV GKRNKDPSTL LWIGDWDARN 180 ARDLMSYTAH EGYKIDSYEL GNELTGEGVS ATIDPEQYAM DTKQLREAVN ELYPDPSSRP 240 KVLGPAGFFD KEWFKKYLQA LGPNVVDGVT HHIYNLGAGV DPTLINKVQD PFFLDKIAQT 300 FKDVRDIVDR SGTGASAWVG ESGGAYNSGG KTVSHTFANG FWYLDQLGMT STFNHKVYCR 360 QSLVGGNYGF LKSRSFTPNP DYYGALLWHR LMGNGVLATS HDGSPYLRTY THCSKNTTGV 420 TMLLINMSNS TKFDIWISND LNLYDLGSSS DSSFFLLTED REEYHLTPKG GNIQSDVVLL 480 NGTPLKLTKS GEIPKLAPKL VPASSPVTVA PDSFVYVTIK DFQAPAC* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 8.0e-164 | 40 | 348 | 309 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI27258.1 | 0 | 6 | 527 | 12 | 523 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002274743.1 | 0 | 6 | 527 | 10 | 521 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002315010.1 | 0 | 1 | 527 | 1 | 517 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002512114.1 | 0 | 27 | 526 | 28 | 529 | Heparanase precursor, putative [Ricinus communis] |
RefSeq | XP_002512114.1 | 0.0000000002 | 58 | 105 | 540 | 587 | Heparanase precursor, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.0000001 | 94 | 438 | 75 | 409 | A Chain A, Crystal Structure At 1.45- Resolution Of The Major Allergen Endo-Beta-1,3-Glucanase Of Banana As A Molecular Basis For The Latex-Fruit Syndrome |
PDB | 3vnz_A | 0.0000001 | 94 | 438 | 75 | 409 | A Chain A, Crystal Structure At 1.45- Resolution Of The Major Allergen Endo-Beta-1,3-Glucanase Of Banana As A Molecular Basis For The Latex-Fruit Syndrome |
PDB | 3vny_A | 0.0000001 | 94 | 438 | 75 | 409 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |