Basic Information | |
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Species | Linum usitatissimum |
Cazyme ID | Lus10005164 |
Family | GT2 |
Protein Properties | Length: 560 Molecular Weight: 63228.1 Isoelectric Point: 5.6897 |
Chromosome | Chromosome/Scaffold: 370 Start: 203014 End: 207052 |
Description | Nucleotide-diphospho-sugar transferases superfamily protein |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT2 | 68 | 263 | 7.8e-29 |
SLIIPAFNEEHRLPAALDETIKYVEAIIFNKRASKDRSFTYEVLIVDDGSADATKRVEFDFVGKYSVDNVRVILLGQNHGKGEAIRKGMLHSRGELLLML DADGATKVTDLEKLEQKILAVANAEDTKDGKSAFRIGDIPVVAFGSRAHLEEKALASRKWYRNFLMKGFHLVVLLAAGPGIRDTQCGFKMFTRAAA |
Full Sequence |
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Protein Sequence Length: 560 Download |
MELLWTIAEQ FFVLILIVGI LLLSAMIFEA YRRRNNKHID RPAFFEDPNS LKQIPSPHLI 60 DPAEKYISLI IPAFNEEHRL PAALDETIKY VEAIIFNKRA SKDRSFTYEV LIVDDGSADA 120 TKRVEFDFVG KYSVDNVRVI LLGQNHGKGE AIRKGMLHSR GELLLMLDAD GATKVTDLEK 180 LEQKILAVAN AEDTKDGKSA FRIGDIPVVA FGSRAHLEEK ALASRKWYRN FLMKGFHLVV 240 LLAAGPGIRD TQCGFKMFTR AAAGKLFANI RLKRWCLDVE LAEEFSSILP EMAGSPFLIE 300 FKRQASFFIK EKIKTTRLAL TDVTPAQLLT EEATSEDVWP PDTRSMGAIS KAAFDVDDYW 360 RIVDIVHHKL ISYDEESWRV SYKTLLLLEH LLTHGPLRVA EEFERRRPVI RKMGSSFAFY 420 SEKGCKLNWG LRVRNLSRRV VKLIEDGEFL IEERTRLRKL TSGIQGFGSF NNDQPSTSFS 480 DSDDGQSPDS TGSQSPDSTG GFTLTMLTRL NSNEDCSENQ IHSYEELPME DDETEAISIE 540 CHNLLFNSDN PTTVSLSSP* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam01417 | ENTH | 1.0e-20 | 323 | 450 | 128 | + ENTH domain. The ENTH (Epsin N-terminal homology) domain is found in proteins involved in endocytosis and cytoskeletal machinery. The function of the ENTH domain is unknown. | ||
cd03571 | ENTH_epsin | 6.0e-24 | 325 | 450 | 126 | + ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet unique module referred to as an AP180 N-terminal homology (ANTH) domain. ENTH and ANTH (E/ANTH) domains are structurally similar to the VHS domain and are composed of a superhelix of eight alpha helices. E/ANTH domains bind both inositol phospholipids and proteins and contribute to the nucleation and formation of clathrin coats on membranes. ENTH domains also function in the development of membrane curvature through lipid remodeling during the formation of clathrin-coated vesicles. E/ANTH-bearing proteins have recently been shown to function with adaptor protein-1 and GGA adaptors at the trans-Golgi network, which suggests that E/ANTH domains are universal components of the machinery for clathrin-mediated membrane budding. | ||
cd04179 | DPM_DPG-synthase_like | 2.0e-42 | 69 | 281 | 213 | + DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily. DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily. | ||
PTZ00260 | PTZ00260 | 3.0e-68 | 63 | 281 | 222 | + dolichyl-phosphate beta-glucosyltransferase; Provisional | ||
cd04188 | DPG_synthase | 7.0e-78 | 69 | 281 | 213 | + DPG_synthase is involved in protein N-linked glycosylation. UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
RefSeq | NP_181493.1 | 0 | 32 | 282 | 33 | 282 | glycosyl transferase family 2 protein [Arabidopsis thaliana] |
RefSeq | XP_002283615.1 | 0 | 32 | 281 | 33 | 282 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002312095.1 | 0 | 30 | 281 | 30 | 281 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002315224.1 | 0 | 31 | 281 | 31 | 281 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002530857.1 | 0 | 32 | 281 | 33 | 281 | Dolichyl-phosphate beta-glucosyltransferase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 2v8s_E | 0.0000000006 | 332 | 454 | 11 | 130 | V Chain V, Vti1b Habc Domain - Epsinr Enth Domain Complex |
PDB | 2qy7_C | 0.0000000006 | 332 | 454 | 11 | 130 | A Chain A, Crystal Structure Of Human Epsinr Enth Domain |
PDB | 2qy7_B | 0.0000000006 | 332 | 454 | 11 | 130 | A Chain A, Crystal Structure Of Human Epsinr Enth Domain |
PDB | 2qy7_A | 0.0000000006 | 332 | 454 | 11 | 130 | A Chain A, Crystal Structure Of Human Epsinr Enth Domain |
PDB | 1xgw_A | 0.000000001 | 332 | 454 | 41 | 160 | A Chain A, The Crystal Structure Of Human Enthoprotin N-Terminal Domain |