Basic Information | |
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Species | Linum usitatissimum |
Cazyme ID | Lus10006171 |
Family | GH28 |
Protein Properties | Length: 612 Molecular Weight: 66689.3 Isoelectric Point: 8.3534 |
Chromosome | Chromosome/Scaffold: 779 Start: 127433 End: 133638 |
Description | MATE efflux family protein |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH28 | 453 | 585 | 9.3e-37 |
IGKGTFDGLGTAAWDKNDCAKNNNCKNLPFNLRFNFVKQAPIEGVTFKDSKNFNVNVLGCENITFCNFHVGAPEESPNTDGIHMGKSTGVSIIDPTSETG YDCISIRDGIKQLRIENVKCGPGHEISIGSLGE |
Full Sequence |
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Protein Sequence Length: 612 Download |
MEGRSSKWVV CLNEVKTVSL VAAPMVVVTV LQFLVQFVAT MMVGHLDQLS LSAASIGAAF 60 SLVTGFTVLA GMAGGLETLC GQAYGAEQYH KLGTYMYSAI TSMTLVCFPI SILWIFTDKF 120 LILAGQDHLI SILARKYSIC LVPGLFGSAM LQAMTRYFQT QSLILPMLFA SLATMCLHVP 180 LCWFLVFKTG LRYLGAALAV SISTWANVIL LVIYMTCSSK CSKTLSKSKF RDLYLGTAEF 240 LRFAIPSAMM TCLEWWSYDL LILLAGLLPN PKLESSVISI CFSITYLHYY IPYGFGATIS 300 TRVSNELGAG KPKAAKMAVQ AVMILAIIEL AVVILPLFLC RHILGYVFSN DKEIVDYVAD 360 MAPFMCLSAT MDTLQSVLSG VVRGSGKQNL GAFVNLGAYY VVGTPLAVVL AFVAHLRGKG 420 LLIGLATGSG LQATMFAVRI FLTDWEQQNE QNIGKGTFDG LGTAAWDKND CAKNNNCKNL 480 PFNLRFNFVK QAPIEGVTFK DSKNFNVNVL GCENITFCNF HVGAPEESPN TDGIHMGKST 540 GVSIIDPTSE TGYDCISIRD GIKQLRIENV KCGPGHEISI GSLGEKPWGR ACCRSVRQKL 600 YLNQHSKWSK D* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam00295 | Glyco_hydro_28 | 5.0e-34 | 454 | 588 | 135 | + Glycosyl hydrolases family 28. Glycosyl hydrolase family 28 includes polygalacturonase EC:3.2.1.15 as well as rhamnogalacturonase A(RGase A), EC:3.2.1.-. These enzymes is important in cell wall metabolism. | ||
COG0534 | NorM | 6.0e-38 | 14 | 445 | 435 | + Na+-driven multidrug efflux pump [Defense mechanisms] | ||
cd13131 | MATE_NorM_like | 6.0e-39 | 14 | 445 | 444 | + Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate. | ||
TIGR00797 | matE | 2.0e-44 | 40 | 365 | 330 | + putative efflux protein, MATE family. The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS [Transport and binding proteins, Other]. | ||
cd13132 | MATE_eukaryotic | 2.0e-137 | 14 | 448 | 435 | + Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress. |
Gene Ontology | |
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GO Term | Description |
GO:0004650 | polygalacturonase activity |
GO:0005975 | carbohydrate metabolic process |
GO:0006855 | drug transmembrane transport |
GO:0015238 | drug transmembrane transporter activity |
GO:0015297 | antiporter activity |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
RefSeq | NP_001151913.1 | 0 | 8 | 451 | 28 | 471 | LOC100285550 [Zea mays] |
RefSeq | XP_002314825.1 | 0 | 5 | 461 | 23 | 481 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002458328.1 | 0 | 8 | 451 | 30 | 473 | hypothetical protein SORBIDRAFT_03g031420 [Sorghum bicolor] |
RefSeq | XP_002528064.1 | 0 | 13 | 448 | 16 | 450 | TRANSPARENT TESTA 12 protein, putative [Ricinus communis] |
RefSeq | XP_002532229.1 | 0 | 8 | 449 | 25 | 465 | TRANSPARENT TESTA 12 protein, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3mku_B | 1e-19 | 13 | 453 | 9 | 453 | A Chain A, Structure Of Apo Sucrose Phosphate Synthase (Sps) Of Halothermothrix Orenii |
PDB | 3mku_A | 1e-19 | 13 | 453 | 9 | 453 | A Chain A, Structure Of Apo Sucrose Phosphate Synthase (Sps) Of Halothermothrix Orenii |
PDB | 3mkt_B | 1e-19 | 13 | 453 | 9 | 453 | A Chain A, Structure Of A Cation-Bound Multidrug And Toxin Compound Extrusion (Mate) Transporter |
PDB | 3mkt_A | 1e-19 | 13 | 453 | 9 | 453 | A Chain A, Structure Of A Cation-Bound Multidrug And Toxin Compound Extrusion (Mate) Transporter |
PDB | 4hun_A | 0.0000000003 | 10 | 412 | 8 | 413 | A Chain A, Structure Of A Cation-Bound Multidrug And Toxin Compound Extrusion (Mate) Transporter |
Transmembrane Domains | ||||
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Start | End | |||
20 | 39 | |||
52 | 74 | |||
94 | 116 | |||
137 | 154 | |||
164 | 186 | |||
193 | 215 | |||
246 | 268 | |||
275 | 297 | |||
317 | 339 | |||
393 | 415 | |||
420 | 442 |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
EL435412 | 312 | 94 | 405 | 0 |
DV161206 | 296 | 7 | 302 | 0 |
GW895099 | 289 | 13 | 301 | 0 |
DY296547 | 306 | 12 | 317 | 0 |
DY971418 | 296 | 118 | 413 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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