| Basic Information | |
|---|---|
| Species | Linum usitatissimum |
| Cazyme ID | Lus10008823 |
| Family | GH79 |
| Protein Properties | Length: 560 Molecular Weight: 61232.3 Isoelectric Point: 7.141 |
| Chromosome | Chromosome/Scaffold: 300 Start: 266381 End: 268802 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
|---|
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 62 | 553 | 0 |
| DEDFICATLDWWPPEKCDYGTCAWDHASLVNLDLNDQILLKAIQAFSPLKIRLGGTLQDKVIYDTPDNHQPCPQFVKNTSELFGFTPGCLPMYRWDELNS FFNKSGAKIIFGLNALLGRTMQPDGSEAGPWNYTNAQSFMNYTVTHNYSIHGWELGNELSGSGVGTRVSADQYASDTISLHDIVDKIYNGIEPKPLVLAP GGFYDSNWFQTLINKTGNALDVVTHHIYNLGPGVDEHLIEKILDPTVLDNVIGTFQGLQSLLRSSPSSATAWVGESGGAYNSGHNLVSNAFVYSFWYLDQ LALSASHDTKTYCRQSLIGGNYGLLNTTTFVPNPDYYSALLWHQLMGRNALSTSVSASKKLRTYAHCSKHSKRFTVLLINLDNSTTFHLNVGLNRTSSLL FQYKHKKKSHHRFEHRTNIVKLPRRSKIGAMRDEYHLTAKDGNLQSQTMLLNGNILTLNSQGDIPALEPIQVNSSAPIVVAPLSIVFARLPY | |||
| Full Sequence |
|---|
| Protein Sequence Length: 560 Download |
| MGSQSSVMGL VVLLCLLCCC TFVPVSSQGG GNGNGNGTSS SSSSVVEGMI VVDGSSAIGR 60 TDEDFICATL DWWPPEKCDY GTCAWDHASL VNLDLNDQIL LKAIQAFSPL KIRLGGTLQD 120 KVIYDTPDNH QPCPQFVKNT SELFGFTPGC LPMYRWDELN SFFNKSGAKI IFGLNALLGR 180 TMQPDGSEAG PWNYTNAQSF MNYTVTHNYS IHGWELGNEL SGSGVGTRVS ADQYASDTIS 240 LHDIVDKIYN GIEPKPLVLA PGGFYDSNWF QTLINKTGNA LDVVTHHIYN LGPGVDEHLI 300 EKILDPTVLD NVIGTFQGLQ SLLRSSPSSA TAWVGESGGA YNSGHNLVSN AFVYSFWYLD 360 QLALSASHDT KTYCRQSLIG GNYGLLNTTT FVPNPDYYSA LLWHQLMGRN ALSTSVSASK 420 KLRTYAHCSK HSKRFTVLLI NLDNSTTFHL NVGLNRTSSL LFQYKHKKKS HHRFEHRTNI 480 VKLPRRSKIG AMRDEYHLTA KDGNLQSQTM LLNGNILTLN SQGDIPALEP IQVNSSAPIV 540 VAPLSIVFAR LPYALPACK* |
| Functional Domains Download unfiltered results here | ||||||
|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description |
| pfam03662 | Glyco_hydro_79n | 0 | 46 | 362 | 318 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAN81917.1 | 0 | 8 | 559 | 1 | 555 | hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002263173.1 | 0 | 8 | 559 | 5 | 559 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002324603.1 | 0 | 48 | 558 | 1 | 505 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002331013.1 | 0 | 8 | 558 | 1 | 546 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002533671.1 | 0 | 1 | 559 | 1 | 551 | heparanase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.00000009 | 157 | 443 | 122 | 401 | A Chain A, The Structure Of Endoglucanase From Termite, Nasutitermes Takasagoensis, At Ph 2.5. |
| PDB | 3vnz_A | 0.00000009 | 157 | 443 | 122 | 401 | A Chain A, The Structure Of Endoglucanase From Termite, Nasutitermes Takasagoensis, At Ph 2.5. |
| PDB | 3vny_A | 0.00000009 | 157 | 443 | 122 | 401 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
