y
Basic Information | |
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Species | Linum usitatissimum |
Cazyme ID | Lus10021652 |
Family | GH79 |
Protein Properties | Length: 541 Molecular Weight: 59844.1 Isoelectric Point: 9.2023 |
Chromosome | Chromosome/Scaffold: 208 Start: 246927 End: 250067 |
Description | glucuronidase 2 |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 39 | 534 | 0 |
DDNYVCATLDWWPHDKCDYNHCPWGYTSAVNLDVSHPVLGKAIQAFSPLRIRIGGSLQDQVLYDVGNLGSNCHSFFKMKWGLFGFSKGCLRMDRWDSLNN LFSRTGAMVTFGLNALRGRHKTWGKHWGGSWNSTNTYDFISYTISKGHKIDSWEYGNELSGTGIGASVSVDTYAKDVIKLREIVDTLYKNSKRKPSVMAP GGFFEKDWYAKLLKITGPGTINVVTHHIYNLGAGVDPHLIQHIMDPNYLSKVSKTFGNLSQTIQQNGPWASAWVGESGGAYNSGGFHISDTFVNSFWYLD QLGLAATYNTKVYCRQTLVGGHYSLLNTTTFVQNPDYYSALLWHRLMGKIVLGVTSTASPYLRYYAHCSRGRQGITVLLINLSNSTRFIVNIRSSSSLAL DLKAREPGTKSSFIDSLKRSVSWIGSEATEGSLFREEYHLSPKDGDLRSKTMLLNGNPIQVTEKGDIPKLEPMRYKLSSPLYISSSSMSFVVLPNF |
Full Sequence |
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Protein Sequence Length: 541 Download |
MGLWGFSVIP LAFLHVIVAQ EIMTATVVVS GAAKVAETDD NYVCATLDWW PHDKCDYNHC 60 PWGYTSAVNL DVSHPVLGKA IQAFSPLRIR IGGSLQDQVL YDVGNLGSNC HSFFKMKWGL 120 FGFSKGCLRM DRWDSLNNLF SRTGAMVTFG LNALRGRHKT WGKHWGGSWN STNTYDFISY 180 TISKGHKIDS WEYGNELSGT GIGASVSVDT YAKDVIKLRE IVDTLYKNSK RKPSVMAPGG 240 FFEKDWYAKL LKITGPGTIN VVTHHIYNLG AGVDPHLIQH IMDPNYLSKV SKTFGNLSQT 300 IQQNGPWASA WVGESGGAYN SGGFHISDTF VNSFWYLDQL GLAATYNTKV YCRQTLVGGH 360 YSLLNTTTFV QNPDYYSALL WHRLMGKIVL GVTSTASPYL RYYAHCSRGR QGITVLLINL 420 SNSTRFIVNI RSSSSLALDL KAREPGTKSS FIDSLKRSVS WIGSEATEGS LFREEYHLSP 480 KDGDLRSKTM LLNGNPIQVT EKGDIPKLEP MRYKLSSPLY ISSSSMSFVV LPNFGAPACA 540 * 600 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 0 | 25 | 341 | 317 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CAB62595.1 | 0 | 18 | 540 | 1 | 521 | putative protein [Arabidopsis thaliana] |
EMBL | CBI15157.1 | 0 | 12 | 540 | 12 | 513 | unnamed protein product [Vitis vinifera] |
RefSeq | NP_196400.2 | 0 | 18 | 540 | 23 | 543 | AtGUS2 (Arabidopsis thaliana glucuronidase 2); beta-glucuronidase |
RefSeq | XP_002284470.1 | 0 | 12 | 540 | 12 | 539 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002514696.1 | 0 | 16 | 540 | 16 | 539 | Heparanase-2, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.0001 | 89 | 442 | 75 | 423 | A Chain A, Solution Structure Of The C-Terminal Domain Ole E 9 |
PDB | 3vnz_A | 0.0001 | 89 | 442 | 75 | 423 | A Chain A, Solution Structure Of The C-Terminal Domain Ole E 9 |
PDB | 3vny_A | 0.0001 | 89 | 442 | 75 | 423 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |