y
Basic Information | |
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Species | Linum usitatissimum |
Cazyme ID | Lus10029494 |
Family | GH89 |
Protein Properties | Length: 781 Molecular Weight: 88807.2 Isoelectric Point: 5.5347 |
Chromosome | Chromosome/Scaffold: 55 Start: 367419 End: 372398 |
Description | alpha-N-acetylglucosaminidase family / NAGLU family |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH89 | 74 | 776 | 0 |
AEIIIKGTTAVEIVSGLHWYIKYWCGAHVSWDKTGGIQIVSIPKPGSLPRVKNGGIMIQRPVPWNYYQNVVTSSYSYVWWNWERWEKEIDWMALQGINLP LAFNGQEAIWQKVFMKFNISAHDLDGFFGGPAFLAWARMGNLHGWGGPLSQSWLDGQLTLQKQILARMLELGMTPVLPSFSGNVPAALSKVFPSAKITRL GDWNTVNKNPRWCCTYLLDPSDPLFVEIGRAFIKKQIEEYGDVTDIYNCDTFNENSPPTDDPEYITSLGAAVYKAMSAGDQNAVWLMQGWLFYSDFVFWQ PPQVKALLHSVPFGKMIVLDLFAESKPIWEISSQFYDTPYVWCMLHNFGGNLEMYGMLDSIASGPVDARVSDNSTMVGVGLCMEGIEHNPVVYELMSEMT FREEKVHVLEWLKTYALRRYGKAVPQIDEAWDILYHTIYNCTDGVADHNTDFIVKLPDWDPSLHSDNSKQEKIHTLHIGGRFLFQLQSSDLPEAHIWYSN QDTVKALQLFLGAGDKLNGSLTYRYDLVDLTRQVLSKLANEVYTEAILAFRNKDVNSLKNYSKKFLELIEDIDVLLASDDNFLLGTWLESAKALADNPID SKLNEWNARTQVTMWYDTTEAIQSKLHDYANKFWSGLLEDYYLPRASTYFDHLIKTLEKNEEFSLVDWRVKWIALSNKWQTGSNLYPVKAKGDALSISRL LFE |
Full Sequence |
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Protein Sequence Length: 781 Download |
MSEGRRDAIE SLVSRLDSRK SSSSVQESAA RGVLIRLLPA YQNSFDFKIV SKEACSGKSC 60 FLIGNQAKPN LNGAEIIIKG TTAVEIVSGL HWYIKYWCGA HVSWDKTGGI QIVSIPKPGS 120 LPRVKNGGIM IQRPVPWNYY QNVVTSSYSY VWWNWERWEK EIDWMALQGI NLPLAFNGQE 180 AIWQKVFMKF NISAHDLDGF FGGPAFLAWA RMGNLHGWGG PLSQSWLDGQ LTLQKQILAR 240 MLELGMTPVL PSFSGNVPAA LSKVFPSAKI TRLGDWNTVN KNPRWCCTYL LDPSDPLFVE 300 IGRAFIKKQI EEYGDVTDIY NCDTFNENSP PTDDPEYITS LGAAVYKAMS AGDQNAVWLM 360 QGWLFYSDFV FWQPPQVKAL LHSVPFGKMI VLDLFAESKP IWEISSQFYD TPYVWCMLHN 420 FGGNLEMYGM LDSIASGPVD ARVSDNSTMV GVGLCMEGIE HNPVVYELMS EMTFREEKVH 480 VLEWLKTYAL RRYGKAVPQI DEAWDILYHT IYNCTDGVAD HNTDFIVKLP DWDPSLHSDN 540 SKQEKIHTLH IGGRFLFQLQ SSDLPEAHIW YSNQDTVKAL QLFLGAGDKL NGSLTYRYDL 600 VDLTRQVLSK LANEVYTEAI LAFRNKDVNS LKNYSKKFLE LIEDIDVLLA SDDNFLLGTW 660 LESAKALADN PIDSKLNEWN ARTQVTMWYD TTEAIQSKLH DYANKFWSGL LEDYYLPRAS 720 TYFDHLIKTL EKNEEFSLVD WRVKWIALSN KWQTGSNLYP VKAKGDALSI SRLLFEKYFS 780 * 840 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam12971 | NAGLU_N | 2.0e-21 | 26 | 124 | 99 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
pfam12972 | NAGLU_C | 4.0e-108 | 483 | 778 | 296 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
pfam05089 | NAGLU | 0 | 139 | 478 | 340 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI24942.1 | 0 | 2 | 780 | 84 | 868 | unnamed protein product [Vitis vinifera] |
GenBank | EEE59081.1 | 0 | 21 | 780 | 51 | 812 | hypothetical protein OsJ_10898 [Oryza sativa Japonica Group] |
RefSeq | NP_196873.1 | 0 | 8 | 779 | 27 | 805 | alpha-N-acetylglucosaminidase family / NAGLU family [Arabidopsis thaliana] |
RefSeq | XP_002273084.1 | 0 | 2 | 780 | 19 | 803 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002314048.1 | 0 | 5 | 779 | 25 | 805 | predicted protein [Populus trichocarpa] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 2vcc_A | 0 | 41 | 778 | 186 | 877 | A Chain A, Crystal Structure Of Medicago Truncatula Ugt71g1 |
PDB | 2vcb_A | 0 | 41 | 778 | 186 | 877 | A Chain A, Crystal Structure Of Medicago Truncatula Ugt71g1 |
PDB | 2vca_A | 0 | 41 | 778 | 186 | 877 | A Chain A, Crystal Structure Of Medicago Truncatula Ugt71g1 |
PDB | 2vc9_A | 0 | 41 | 778 | 186 | 877 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
PDB | 4a4a_A | 0 | 41 | 778 | 209 | 900 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
HO783455 | 321 | 284 | 601 | 0 |
HO783455 | 147 | 610 | 756 | 0 |
GT627657 | 271 | 186 | 456 | 0 |
GT622356 | 273 | 259 | 531 | 0 |
HO783128 | 421 | 325 | 745 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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