| Basic Information | |
|---|---|
| Species | Linum usitatissimum |
| Cazyme ID | Lus10031374 |
| Family | CBM57 |
| Protein Properties | Length: 1145 Molecular Weight: 127252 Isoelectric Point: 8.1831 |
| Chromosome | Chromosome/Scaffold: 863 Start: 81307 End: 88080 |
| Description | Leucine-rich repeat transmembrane protein kinase |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| CBM57 | 536 | 705 | 1.6e-34 |
| HINCGGKEMNLNKTLYQADREPRGASMYYSSQNWVFSSTGHFADNDLDADTYIQYNHSAISTTNIISANNNSELYTTARGSPISLTYYGLCLGNGNYTVR LHFAEIVFTNDSSFISVGKRIFDVYVQDKLVLKDFNIEAEAGGPGRPIVKTYTVTITNNTLKVHFYWAGR | |||
| Full Sequence |
|---|
| Protein Sequence Length: 1145 Download |
| MRWCVEPGYT EMQFETDAQT VVSGLRTGGE DWSEFGDILR SCREVLDAFP IFYVTFASRN 60 CNAVAHEIAQ RSVTQMVAMG GDVPRSEIDS NYKLHPSEVK ALRDIGKKLG KKGWDFGKDP 120 CSEEGSWDVK DSRKGFENSV ICDCPVSASA SAVAVHGSLN LNNSTTFGSS CHVTSILLKS 180 QNLSGTLPPE FSRLRYLKKL ELSKNILTGT IPPQWATLRL VELYLMGNRL SGAFPKVLTN 240 MTTLRNLSIE ANEFSGPLPP EIGRMINIER LHINSNAFTG KLPVQLSKLV NLTDIRISDN 300 NFSGKIPDFI SKLTKLEKLW VEHSAASPTR HIQGCPMEGP IPSSISALTS LTDLRITDLK 360 GRGSSFPPLS AMESMKTLVL RNILLSGRIP EYLIKMKKLK TLDLSFNSLT GEIPESFVLL 420 AKVDIIYLTG NRLRGSVPQW ILERNKIVYV YLVGILAFYW NFLFLQRLMN RLFMRSDVSY 480 NNFTWESSSP TECPQGSVNL VESYSSSTTK QSRIHPCLRQ KFPCCLSRKE YRYSLHINCG 540 GKEMNLNKTL YQADREPRGA SMYYSSQNWV FSSTGHFADN DLDADTYIQY NHSAISTTNI 600 ISANNNSELY TTARGSPISL TYYGLCLGNG NYTVRLHFAE IVFTNDSSFI SVGKRIFDVY 660 VQDKLVLKDF NIEAEAGGPG RPIVKTYTVT ITNNTLKVHF YWAGRGTTGI PVRGVYGPLI 720 SAISVDPNFT PPSPEDSRRH IIIIAGAVSG ALSLVLLILG ILWRKGLLAG QAAEEKELRG 780 LLDQQTGLFA LRQIKAATKN FDPANKLGEG GFGCVYKGEL PDGTVIAVKQ LSSKSKQGNR 840 EFVTEVGMIS GIQHPNMVKL YGCCVEGNQL ILIYEYMENN CLSRALFAKD PACRLKLDWP 900 SRQKICIGVA RGLAYLHEES RIRVVHRDIK TSNVLLDKDL NPKISDFGLA KLHEDEDTHI 960 STRVAGTIGY MAPEYAMRGC LTSKADVYSF GVVALEIVSG KSNTNYRPKE EYVYLLDWAY 1020 VLQERGCLLE LVDPALGLEY SAEEAMLMLN VALLCTNASP SLRPTMSQAV SMLEGRTAIQ 1080 DLLSDPGYSA NRAKYKAIRN HFWQNPSRTQ SMSTDDGYTD YSSRHPEVEE SGSLLRAVSS 1140 KTED* 1200 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam07714 | Pkinase_Tyr | 3.0e-49 | 806 | 1073 | 290 | + Protein tyrosine kinase. | ||
| cd00192 | PTKc | 1.0e-51 | 805 | 1074 | 287 | + Catalytic domain of Protein Tyrosine Kinases. Protein Tyrosine Kinase (PTK) family, catalytic domain. This PTKc family is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. They can be classified into receptor and non-receptor tyr kinases. PTKs play important roles in many cellular processes including, lymphocyte activation, epithelium growth and maintenance, metabolism control, organogenesis regulation, survival, proliferation, differentiation, migration, adhesion, motility, and morphogenesis. Receptor tyr kinases (RTKs) are integral membrane proteins which contain an extracellular ligand-binding region, a transmembrane segment, and an intracellular tyr kinase domain. RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain, leading to intracellular signaling. Some RTKs are orphan receptors with no known ligands. Non-receptor (or cytoplasmic) tyr kinases are distributed in different intracellular compartments and are usually multi-domain proteins containing a catalytic tyr kinase domain as well as various regulatory domains such as SH3 and SH2. PTKs are usually autoinhibited and require a mechanism for activation. In many PTKs, the phosphorylation of tyr residues in the activation loop is essential for optimal activity. Aberrant expression of PTKs is associated with many development abnormalities and cancers. | ||
| smart00221 | STYKc | 5.0e-52 | 806 | 1073 | 277 | + Protein kinase; unclassified specificity. Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase. | ||
| smart00219 | TyrKc | 9.0e-53 | 806 | 1073 | 277 | + Tyrosine kinase, catalytic domain. Phosphotransferases. Tyrosine-specific kinase subfamily. | ||
| pfam11721 | Malectin | 2.0e-60 | 533 | 723 | 195 | + Di-glucose binding within endoplasmic reticulum. Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognises and binds Glc2-N-glycan. It carries a signal peptide from residues 1-26, a C-terminal transmembrane helix from residues 255-274, and a highly conserved central part of approximately 190 residues followed by an acidic, glutamate-rich region. Carbohydrate-binding is mediated by the four aromatic residues, Y67, Y89, Y116, and F117 and the aspartate at D186. NMR-based ligand-screening studies has shown binding of the protein to maltose and related oligosaccharides, on the basis of which the protein has been designated "malectin", and its endogenous ligand is found to be Glc2-high-mannose N-glycan. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0004672 | protein kinase activity |
| GO:0005515 | protein binding |
| GO:0005524 | ATP binding |
| GO:0006468 | protein phosphorylation |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAN60698.1 | 0 | 216 | 1120 | 81 | 950 | hypothetical protein [Vitis vinifera] |
| RefSeq | NP_172244.2 | 0 | 85 | 1135 | 21 | 1013 | leucine-rich repeat transmembrane protein kinase, putative [Arabidopsis thaliana] |
| RefSeq | XP_002278131.1 | 0 | 93 | 1137 | 24 | 1004 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002306015.1 | 0 | 99 | 1135 | 1 | 977 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002532988.1 | 0 | 178 | 1137 | 7 | 920 | conserved hypothetical protein [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3ulz_A | 0 | 785 | 1075 | 16 | 308 | A Chain A, Three-Dimensional Structure Of A Lama Vhh Domain Unliganded |
| PDB | 3uim_A | 0 | 785 | 1075 | 16 | 308 | A Chain A, Structural Basis For The Impact Of Phosphorylation On Plant Receptor- Like Kinase Bak1 Activation |
| PDB | 3tl8_H | 0 | 785 | 1075 | 24 | 316 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
| PDB | 3tl8_G | 0 | 785 | 1075 | 24 | 316 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
| PDB | 3tl8_D | 0 | 785 | 1075 | 24 | 316 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
