y
Basic Information | |
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Species | Linum usitatissimum |
Cazyme ID | Lus10035019 |
Family | GH31 |
Protein Properties | Length: 941 Molecular Weight: 105241 Isoelectric Point: 5.0908 |
Chromosome | Chromosome/Scaffold: 43 Start: 53903 End: 57460 |
Description | alpha-xylosidase 1 |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH31 | 281 | 776 | 0 |
FYFFAGPTPLSVVDQYTSLIGRPAPMPYWAFGFHQSKWGYGNIAMVENVVDNYKKARIPLDVIWSDDDYMDLHKDFTISPDNYPLQQLNSFLDKIHSIGM KYVVIVEPGISTNSTYGVLQRGFDNDVFLKQHGRPLLGQVWAGPVHFPDYLNPKTLSWWTDEIRAFLQKVPAVDGLWLDMNEPVTFCFGDCKSPEQSGRP CPGEEPFWVCCLDCEASVTTRWDDPPYKINITGSQQPLGRFTISTSAVHYNGVLEYDAHNLYGLTQTIATHRSLLDIRGEKRPFVLSRASYVGLGKYAAH WSGDNKATWDDLKYSITTMLNFGIFGVPMMGSDICGFYPAPTEELCNRWIELGAFYPFSRDHSNVASPSQELYMWESVAESARNALGLRYKLLPYLYTLN YEAHTTGAPISRPLFFSFPNYSECYGVSTQFLLGSTVMVSPVLEEGKTQVNALFPPGSWYNIFNMSHHAIDSKGEYFTLESPLNLINVHVYQNTIL |
Full Sequence |
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Protein Sequence Length: 941 Download |
MLPRCFSNVL HSLVLLFLCF FFHGVIITSA SASVPSKIGN GYRLISIQQT SDGGLLGRLQ 60 VKQPNDIYGP DIPLLQLFVK HETEDRLRVH ITDAEKQRWE VPYDILPRQQ PPARTSITTS 120 NHNKLISIQD YLTTSWGELI FNYEEDPFSF SVSRKSDGQI LFDSKSEESD TFGPMSFKDQ 180 YLEISTKLPQ EEASLYGLGE STRPSGIKLN PGDSYTLYVS DAMAYEANIG LCGAHPVYMD 240 LRNLNGAAYA HGVLLLNSNG MDVFYRGSSL TYKVIGGVLD FYFFAGPTPL SVVDQYTSLI 300 GRPAPMPYWA FGFHQSKWGY GNIAMVENVV DNYKKARIPL DVIWSDDDYM DLHKDFTISP 360 DNYPLQQLNS FLDKIHSIGM KYVVIVEPGI STNSTYGVLQ RGFDNDVFLK QHGRPLLGQV 420 WAGPVHFPDY LNPKTLSWWT DEIRAFLQKV PAVDGLWLDM NEPVTFCFGD CKSPEQSGRP 480 CPGEEPFWVC CLDCEASVTT RWDDPPYKIN ITGSQQPLGR FTISTSAVHY NGVLEYDAHN 540 LYGLTQTIAT HRSLLDIRGE KRPFVLSRAS YVGLGKYAAH WSGDNKATWD DLKYSITTML 600 NFGIFGVPMM GSDICGFYPA PTEELCNRWI ELGAFYPFSR DHSNVASPSQ ELYMWESVAE 660 SARNALGLRY KLLPYLYTLN YEAHTTGAPI SRPLFFSFPN YSECYGVSTQ FLLGSTVMVS 720 PVLEEGKTQV NALFPPGSWY NIFNMSHHAI DSKGEYFTLE SPLNLINVHV YQNTILPMQQ 780 GGLISKDARM TPFSLVVTFP VGARESEAKG NLFIDNDDLP EMKLGNGESS YVEFHANLSY 840 GWVKLWSEVK EGEFALSQGL AIEKVIVLGL DGRKGSPSDL QFYGIHTSTT TSKANVTSSE 900 QVVIESGDGK RNEITTMLVE VSGLEIPIGK SFGMLFHMEP * 960 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
cd06602 | GH31_MGAM_SI_GAA | 3.0e-76 | 301 | 466 | 170 | + This family includes the following three closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), and lysosomal acid alpha-glucosidase (GAA), also known as acid-maltase. MGAM is one of the two enzymes responsible for catalyzing the last glucose-releasing step in starch digestion. SI is implicated in the digestion of dietary starch and major disaccharides such as sucrose and isomaltose, while GAA degrades glycogen in the lysosome, cleaving both alpha-1,4 and alpha-1,6 glucosidic linkages. MGAM and SI are anchored to small-intestinal brush-border epithelial cells. The absence of SI from the brush border membrane or its malfunction is associated with malabsorption disorders such as congenital sucrase-isomaltase deficiency (CSID). The domain architectures of MGAM and SI include two tandem GH31 catalytic domains, an N-terminal domain found near the membrane-bound end, and a C-terminal luminal domain. Both of the tandem GH31 domains of MGAM and SI are included in this family. The domain architecture of GAA includes an N-terminal TFF (trefoil factor family) domain in addition to the GH31 catalytic domain. Deficient GAA expression causes pompe disease, an autosomal recessive genetic disorder also known as glycogen storage disease type II (GSDII). | ||
cd06602 | GH31_MGAM_SI_GAA | 5.0e-91 | 536 | 705 | 171 | + This family includes the following three closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), and lysosomal acid alpha-glucosidase (GAA), also known as acid-maltase. MGAM is one of the two enzymes responsible for catalyzing the last glucose-releasing step in starch digestion. SI is implicated in the digestion of dietary starch and major disaccharides such as sucrose and isomaltose, while GAA degrades glycogen in the lysosome, cleaving both alpha-1,4 and alpha-1,6 glucosidic linkages. MGAM and SI are anchored to small-intestinal brush-border epithelial cells. The absence of SI from the brush border membrane or its malfunction is associated with malabsorption disorders such as congenital sucrase-isomaltase deficiency (CSID). The domain architectures of MGAM and SI include two tandem GH31 catalytic domains, an N-terminal domain found near the membrane-bound end, and a C-terminal luminal domain. Both of the tandem GH31 domains of MGAM and SI are included in this family. The domain architecture of GAA includes an N-terminal TFF (trefoil factor family) domain in addition to the GH31 catalytic domain. Deficient GAA expression causes pompe disease, an autosomal recessive genetic disorder also known as glycogen storage disease type II (GSDII). | ||
cd06604 | GH31_glucosidase_II_MalA | 3.0e-117 | 301 | 687 | 392 | + Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized in Bacillus thermoamyloliquefaciens where it forms a homohexamer. This family also includes the MalA alpha-glucosidase from Sulfolobus sulfataricus and the AglA alpha-glucosidase from Picrophilus torridus. MalA is part of the carbohydrate-metabolizing machinery that allows this organism to utilize carbohydrates, such as maltose, as the sole carbon and energy source. | ||
COG1501 | COG1501 | 7.0e-122 | 54 | 876 | 849 | + Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism] | ||
pfam01055 | Glyco_hydro_31 | 0 | 282 | 776 | 498 | + Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases. |
Gene Ontology | |
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GO Term | Description |
GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
GO:0005975 | carbohydrate metabolic process |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CAA10382.2 | 0 | 29 | 938 | 32 | 933 | alpha-D-xylosidase [Tropaeolum majus] |
RefSeq | XP_002282429.1 | 0 | 13 | 938 | 8 | 920 | PREDICTED: hypothetical protein isoform 1 [Vitis vinifera] |
RefSeq | XP_002311455.1 | 0 | 28 | 938 | 5 | 906 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002315944.1 | 0 | 31 | 938 | 25 | 924 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002531635.1 | 0 | 1 | 938 | 1 | 926 | alpha-glucosidase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3w38_A | 0 | 2 | 873 | 6 | 854 | A Chain A, Crystal Structure Of A Mammalian Sialyltransferase |
PDB | 3w37_A | 0 | 2 | 873 | 6 | 854 | A Chain A, Crystal Structure Of A Mammalian Sialyltransferase |
PDB | 3ctt_A | 0 | 51 | 871 | 61 | 822 | A Chain A, Crystal Structure Of A Mammalian Sialyltransferase |
PDB | 2qmj_A | 0 | 51 | 871 | 61 | 822 | A Chain A, Crystal Structure Of A Mammalian Sialyltransferase |
PDB | 2qly_A | 0 | 51 | 871 | 61 | 822 | A Chain A, Crystral Structure Of The N-Terminal Subunit Of Human Maltase- Glucoamylase |