Basic Information | |
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Species | Linum usitatissimum |
Cazyme ID | Lus10036962 |
Family | GH79 |
Protein Properties | Length: 539 Molecular Weight: 59600.5 Isoelectric Point: 6.3987 |
Chromosome | Chromosome/Scaffold: 31 Start: 1412554 End: 1414869 |
Description | glucuronidase 1 |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 60 | 533 | 0 |
DDYVCATLDWWRKDKCDYRHCPWGNAGILDVDLNNTLLAKAIKAFDPLRLRVGGSLQDLVTYEVGGAVGIHPSFVKDKDVMLGFKPGSLPMKRWDELNEF FAKTNTKVIFGLNELSGKKKENPSTTQMVGDWDPTNARDFMNYTVQKGYKIDAYELGNELCGDGVDAKIDPEQYAKDTKELRKVLNELYPDPKSRPQVLA PGGFFFKEWFKTYLHACGPNVIDGVTHHVYNLGTGGDPKIIDRIQDPHFLSEVVQLYRDVQEVAEQSGSGASPWVGEGGGAYLSGGINVQSTFVDGYWYL DQLGLAAVHSHKAYCRQAIVGGNYGFLKNDVFTPNPDYYGALLWHRLMGTGVLATSHNGSPFLRAYSHCSKKKSGVTLMLINMSKTSTFHIMITDELNNH HKDSDSSHLKEEREEYHLTPEGGNITSDVVLLNGVPLQLTASGDIPEMPPKLAPASSPVTMVPGSFVYVSIKDF |
Full Sequence |
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Protein Sequence Length: 539 Download |
MSSFNVLLLL CSIILSSFFT LSYSDHPHYE DVHHAHHKMK DPDEITVTIK SGAAVSHTAD 60 DYVCATLDWW RKDKCDYRHC PWGNAGILDV DLNNTLLAKA IKAFDPLRLR VGGSLQDLVT 120 YEVGGAVGIH PSFVKDKDVM LGFKPGSLPM KRWDELNEFF AKTNTKVIFG LNELSGKKKE 180 NPSTTQMVGD WDPTNARDFM NYTVQKGYKI DAYELGNELC GDGVDAKIDP EQYAKDTKEL 240 RKVLNELYPD PKSRPQVLAP GGFFFKEWFK TYLHACGPNV IDGVTHHVYN LGTGGDPKII 300 DRIQDPHFLS EVVQLYRDVQ EVAEQSGSGA SPWVGEGGGA YLSGGINVQS TFVDGYWYLD 360 QLGLAAVHSH KAYCRQAIVG GNYGFLKNDV FTPNPDYYGA LLWHRLMGTG VLATSHNGSP 420 FLRAYSHCSK KKSGVTLMLI NMSKTSTFHI MITDELNNHH KDSDSSHLKE EREEYHLTPE 480 GGNITSDVVL LNGVPLQLTA SGDIPEMPPK LAPASSPVTM VPGSFVYVSI KDFKAPAC* 540 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 5.0e-155 | 42 | 363 | 322 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI27258.1 | 0 | 43 | 538 | 25 | 523 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002274743.1 | 0 | 43 | 538 | 23 | 521 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002315010.1 | 0 | 43 | 538 | 24 | 517 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002512114.1 | 0.000000002 | 31 | 117 | 495 | 584 | Heparanase precursor, putative [Ricinus communis] |
RefSeq | XP_002512114.1 | 0 | 45 | 537 | 31 | 529 | Heparanase precursor, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.000007 | 154 | 426 | 122 | 383 | A Chain A, Golgi Alpha-mannosidase Ii In Complex With Kifunensine |
PDB | 3vnz_A | 0.000007 | 154 | 426 | 122 | 383 | A Chain A, Golgi Alpha-mannosidase Ii In Complex With Kifunensine |
PDB | 3vny_A | 0.000007 | 154 | 426 | 122 | 383 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |