Basic Information | |
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Species | Linum usitatissimum |
Cazyme ID | Lus10037109 |
Family | GH79 |
Protein Properties | Length: 501 Molecular Weight: 55266.5 Isoelectric Point: 6.4079 |
Chromosome | Chromosome/Scaffold: 462 Start: 252040 End: 254242 |
Description | glucuronidase 1 |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 22 | 495 | 0 |
DDYVCATLDWWRKDKCDYRHCPWGNAGILDVDLNNTLLAKAIKAFDPLRLRVGGSLQDLVTYEVGGAVGVHPSFVKDKDVMLGFKPGSLPMKRWDELNEF FAKTNTKVIFGLNELSGKKKENKSTTQMVGDWDPTNARDFMNYTVQKGYKIDAYELGNELCGDGVDAKIDPEQYAKDTKELRKVLNELYPDPKSRPQVLA PGGFFFKEWFKTYLRACGPNVIDGVTHHVYNLGTGGDPKIIDRIQDPHFLSEVVQLYRDVQEVAEQSGSGASPWVGEGGGAYLSGGINVQSTFVDGYWYL DQLGLAAVHSHKAYCRQAIVGGNYGFLKNDVFTPNPDYYGALLWHRLMGTGVLATSHNGSPFLRAYSHCSKKKSGVTLMLINMSKTSTFHITITDELNNH HKDSDSNHLKEEREEYHLTPEGGNITSDVVLLNGVPLQLTASGDIPEMPPRLVPASSPVTMVPGSFVYVSVKDF |
Full Sequence |
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Protein Sequence Length: 501 Download |
MKDPDEITVT IKSGAAVSHT ADDYVCATLD WWRKDKCDYR HCPWGNAGIL DVDLNNTLLA 60 KAIKAFDPLR LRVGGSLQDL VTYEVGGAVG VHPSFVKDKD VMLGFKPGSL PMKRWDELNE 120 FFAKTNTKVI FGLNELSGKK KENKSTTQMV GDWDPTNARD FMNYTVQKGY KIDAYELGNE 180 LCGDGVDAKI DPEQYAKDTK ELRKVLNELY PDPKSRPQVL APGGFFFKEW FKTYLRACGP 240 NVIDGVTHHV YNLGTGGDPK IIDRIQDPHF LSEVVQLYRD VQEVAEQSGS GASPWVGEGG 300 GAYLSGGINV QSTFVDGYWY LDQLGLAAVH SHKAYCRQAI VGGNYGFLKN DVFTPNPDYY 360 GALLWHRLMG TGVLATSHNG SPFLRAYSHC SKKKSGVTLM LINMSKTSTF HITITDELNN 420 HHKDSDSNHL KEEREEYHLT PEGGNITSDV VLLNGVPLQL TASGDIPEMP PRLVPASSPV 480 TMVPGSFVYV SVKDFKAPAC * |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 1.0e-156 | 4 | 325 | 322 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI27258.1 | 0 | 5 | 500 | 25 | 523 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002274743.1 | 0 | 5 | 500 | 23 | 521 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002315010.1 | 0 | 5 | 500 | 24 | 517 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002512114.1 | 0 | 7 | 499 | 31 | 529 | Heparanase precursor, putative [Ricinus communis] |
RefSeq | XP_002512114.1 | 0.000000004 | 9 | 79 | 510 | 584 | Heparanase precursor, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.000006 | 116 | 388 | 122 | 383 | B Chain B, Structural Basis Of Gibberellin(Ga3)-Induced Della Recognition By The Gibberellin Receptor |
PDB | 3vnz_A | 0.000006 | 116 | 388 | 122 | 383 | B Chain B, Structural Basis Of Gibberellin(Ga3)-Induced Della Recognition By The Gibberellin Receptor |
PDB | 3vny_A | 0.000006 | 116 | 388 | 122 | 383 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
HO797031 | 369 | 156 | 500 | 0 |
GR072627 | 263 | 222 | 484 | 0 |
CK266509 | 319 | 61 | 379 | 0 |
JK986839 | 276 | 197 | 472 | 0 |
GO873410 | 318 | 24 | 341 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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