| Basic Information | |
|---|---|
| Species | Linum usitatissimum |
| Cazyme ID | Lus10040618 |
| Family | GT65 |
| Protein Properties | Length: 431 Molecular Weight: 48970.6 Isoelectric Point: 9.1438 |
| Chromosome | Chromosome/Scaffold: 156 Start: 718234 End: 719526 |
| Description | O-fucosyltransferase family protein |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GT65 | 74 | 377 | 0 |
| GLNNQKIAFARSCLTARMLNRTLLMPSLSASLFYKEVDRLQPISFDKVFKFDRFNEMCKGFVQLGRYSDLRNESSNSVYEVQKGSGRRWTVERDLDQLNG IMSDDEHELIRIVGKNPFLWHDHWPVKDYARVFECLALVDEISREADRVVSKIRETGKTMMRASRDGGDANSVPYIAVHMRIEIDWMIHCKKLEQRSNIT EICSSKKEIMERVGNIGGLRNPTVAYLAVADSLLEDSSILSGWKEGLVPMEKKKLGVDGIYKKYPYLIQSAIDYEVCLRADVFVGNSFSTFSSLVALDRT QKTI | |||
| Full Sequence |
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| Protein Sequence Length: 431 Download |
| MDLHSSCKKP RLLVRNLDSL LYKCLALIGL ALFIRAVVVL PFSSYGGIIR MQKLDSVHGI 60 RQNKFLEVPQ IVWGLNNQKI AFARSCLTAR MLNRTLLMPS LSASLFYKEV DRLQPISFDK 120 VFKFDRFNEM CKGFVQLGRY SDLRNESSNS VYEVQKGSGR RWTVERDLDQ LNGIMSDDEH 180 ELIRIVGKNP FLWHDHWPVK DYARVFECLA LVDEISREAD RVVSKIRETG KTMMRASRDG 240 GDANSVPYIA VHMRIEIDWM IHCKKLEQRS NITEICSSKK EIMERVGNIG GLRNPTVAYL 300 AVADSLLEDS SILSGWKEGL VPMEKKKLGV DGIYKKYPYL IQSAIDYEVC LRADVFVGNS 360 FSTFSSLVAL DRTQKTIRMG VTSSCNGVDL RWPTYAYNIL GESNRPHRWM TNMSDSSLKA 420 ISYGTNAISC * 480 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| cd11296 | O-FucT_like | 0.0005 | 65 | 113 | 49 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
| cd11302 | O-FucT-1 | 3.0e-5 | 247 | 372 | 148 | + GDP-fucose protein O-fucosyltransferase 1. The protein O-fucosyltransferase 1 (Ofut1 or O-FucT-1) adds O-fucose to EGF (epidermal growth factor-like) repeats. The O-fucsosylation of the Notch receptor signaling protein is dependent on this enzyme, which requires GDP-fucose as a substrate. O-fucose residues added to the target of O-FucT-1 may be further elongated by other glycosyltransferases. On top of O-fucosylation, O-FucT-1 may have other functions such as the regulation of the Notch receptor exit from the ER. Six highly conserved cysteines are present in O-FucT-1, which is a soluble ER protein, as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The membrane-bound pre-protein is released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. O-FucT-1 is similar to family 1 glycosyltransferases (GT1). | ||
| cd11299 | O-FucT_plant | 2.0e-14 | 74 | 373 | 330 | + GDP-fucose protein O-fucosyltransferase, plant specific subfamily. Some members of this plant-specific family of O-fucosyltransferases have been annotated as auxin-independent growth promotors. The function of the protein seems unclear. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
| cd11296 | O-FucT_like | 2.0e-25 | 195 | 373 | 183 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
| pfam10250 | O-FucT | 2.0e-42 | 74 | 373 | 329 | + GDP-fucose protein O-fucosyltransferase. This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| RefSeq | NP_187183.3 | 0 | 19 | 430 | 16 | 442 | unknown protein [Arabidopsis thaliana] |
| RefSeq | XP_002273827.1 | 0 | 23 | 430 | 4 | 427 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002321799.1 | 0 | 91 | 430 | 1 | 347 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002332132.1 | 0 | 91 | 430 | 1 | 347 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002531235.1 | 0 | 1 | 430 | 1 | 446 | conserved hypothetical protein [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3zy6_A | 0.00001 | 221 | 372 | 192 | 344 | A Chain A, The Three-Dimensional Structures Of Two Plant Beta-Glucan Endohydrolases With Distinct Substrate Specificities |
| PDB | 3zy5_A | 0.00001 | 221 | 372 | 192 | 344 | A Chain A, The Three-Dimensional Structures Of Two Plant Beta-Glucan Endohydrolases With Distinct Substrate Specificities |
| PDB | 3zy4_A | 0.00001 | 221 | 372 | 192 | 344 | A Chain A, The Three-Dimensional Structures Of Two Plant Beta-Glucan Endohydrolases With Distinct Substrate Specificities |
| PDB | 3zy3_B | 0.00001 | 221 | 372 | 192 | 344 | A Chain A, The Three-Dimensional Structures Of Two Plant Beta-Glucan Endohydrolases With Distinct Substrate Specificities |
| PDB | 3zy3_A | 0.00001 | 221 | 372 | 192 | 344 | A Chain A, The Three-Dimensional Structures Of Two Plant Beta-Glucan Endohydrolases With Distinct Substrate Specificities |
