| Basic Information | |
|---|---|
| Species | Linum usitatissimum |
| Cazyme ID | Lus10043468 |
| Family | GH89 |
| Protein Properties | Length: 823 Molecular Weight: 93550.6 Isoelectric Point: 5.7421 |
| Chromosome | Chromosome/Scaffold: 25 Start: 2994673 End: 3000452 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 106 | 807 | 0 |
| DIMISGVTGVEIVAGLHWYLKYWCGAHISWGKTGGAQLNSVPRSGSLPRVQDDGVLVQRPVSWNYYQNAVSSSYTFAWWDWQRWEKEIDWMALHGINLPL AFTGQEAIWQKVFQKFNITKAGLDDFFGGPAFLAWSRMANLHGWGGPLPQSWLDQQLVMQKKILARMYELGMTPVLPAFSGNVPAALIDLFPSAKITRLG NWFSVESNPRWCCTYLLDATDPLFIEIGKAFIEEQLKEYGRTSHIYNCDTFDENTPPVDDPEYVSSLGAATFKGMQAGDKDAIWLMQGWLFAYDDFWKPP QMKALLHSVPLGRLVVLDLYAEVKPIWSASEQFYGVPYIWCMLHNFAGNVEMYGVLDSVASGPVEARLSLNSTMVGVGMSMEGIEQNPIVYDLMSEMAFQ HNKVDVKAWIDLYATRRYGQLVPLIQDAWNILYHTVYNCTDGAYDKNRDVIVAFPDVDPSFISTPLEKYLDDAKPALRRSILQQGAGLYEQPHLWYSTSE VVHALKLFISCGDQLSGSNAYRYDLVDLTRQALAKYANALFLKITKAYKSKNVNGVAEQSRKFVELVEDMDSLLSCHEGFLLGPWLESAKQLAEDEEQEK QFEWNARTQITMWYDNTEEEASLLRDYGNKYWSGLVRDYYGQRAAIYFKYLLESLENDHSFRLKEWRREWIKLTNQWQNSRKKFPVASNGDALLLSTRLY EK | |||
| Full Sequence |
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| Protein Sequence Length: 823 Download |
| MASPTPPPPQ LLLLTVFFLL LSCILPPRQS AAAIGVDSIS RLLEIQDRER ASPSLQVAAA 60 RGVLHRLLPS HTSSFEFRIV SEEKCGGKSC FIISNHPYSA RHGAPDIMIS GVTGVEIVAG 120 LHWYLKYWCG AHISWGKTGG AQLNSVPRSG SLPRVQDDGV LVQRPVSWNY YQNAVSSSYT 180 FAWWDWQRWE KEIDWMALHG INLPLAFTGQ EAIWQKVFQK FNITKAGLDD FFGGPAFLAW 240 SRMANLHGWG GPLPQSWLDQ QLVMQKKILA RMYELGMTPV LPAFSGNVPA ALIDLFPSAK 300 ITRLGNWFSV ESNPRWCCTY LLDATDPLFI EIGKAFIEEQ LKEYGRTSHI YNCDTFDENT 360 PPVDDPEYVS SLGAATFKGM QAGDKDAIWL MQGWLFAYDD FWKPPQMKAL LHSVPLGRLV 420 VLDLYAEVKP IWSASEQFYG VPYIWCMLHN FAGNVEMYGV LDSVASGPVE ARLSLNSTMV 480 GVGMSMEGIE QNPIVYDLMS EMAFQHNKVD VKAWIDLYAT RRYGQLVPLI QDAWNILYHT 540 VYNCTDGAYD KNRDVIVAFP DVDPSFISTP LEKYLDDAKP ALRRSILQQG AGLYEQPHLW 600 YSTSEVVHAL KLFISCGDQL SGSNAYRYDL VDLTRQALAK YANALFLKIT KAYKSKNVNG 660 VAEQSRKFVE LVEDMDSLLS CHEGFLLGPW LESAKQLAED EEQEKQFEWN ARTQITMWYD 720 NTEEEASLLR DYGNKYWSGL VRDYYGQRAA IYFKYLLESL ENDHSFRLKE WRREWIKLTN 780 QWQNSRKKFP VASNGDALLL STRLYEKYLK DSAGNAHYYY DE* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 6.0e-20 | 56 | 155 | 100 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 1.0e-96 | 513 | 808 | 296 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 0 | 170 | 508 | 339 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI15090.1 | 0 | 31 | 811 | 23 | 840 | unnamed protein product [Vitis vinifera] |
| GenBank | EEC78143.1 | 0 | 39 | 812 | 33 | 810 | hypothetical protein OsI_17702 [Oryza sativa Indica Group] |
| RefSeq | XP_002280399.1 | 0 | 31 | 811 | 23 | 807 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002318632.1 | 0 | 31 | 811 | 26 | 806 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002511461.1 | 0 | 12 | 811 | 4 | 802 | alpha-n-acetylglucosaminidase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 75 | 798 | 192 | 866 | E Chain E, Crystal Structure Of Helicoverpa Armigera Stunt Virus |
| PDB | 2vcb_A | 0 | 75 | 798 | 192 | 866 | E Chain E, Crystal Structure Of Helicoverpa Armigera Stunt Virus |
| PDB | 2vca_A | 0 | 75 | 798 | 192 | 866 | E Chain E, Crystal Structure Of Helicoverpa Armigera Stunt Virus |
| PDB | 2vc9_A | 0 | 75 | 798 | 192 | 866 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 75 | 798 | 215 | 889 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
