| Basic Information | |
|---|---|
| Species | Picea abies |
| Cazyme ID | MA_10433885g0020 |
| Family | GH79 |
| Protein Properties | Length: 554 Molecular Weight: 61743.7 Isoelectric Point: 7.5689 |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 61 | 545 | 0 |
| EDFICATLDWWPPNKCDYGTCSWGNASLLNLNLENPLLVNAVKAFDPLKIRLGGTLQDKVIYHVGDLKQPCHPFVKDESLMFGFTNGCLLMSRWDALNDF FNKTGAVLAFGLNALIGRKRMPNGVMGGRWDSSNARDFIQYTVDHGYKINAWELGNELSGSGVGTSISSKQYAADVIELDKILKQIYKDFQEKPLLVAPD GFFEADWFKEVVQKTGPNILNVVTHHIYNLGAGVDEHLVDKILDPSYLSREASTFKSLKAILQRYGPWSSAWVGEAGGAYNSGHNLVTNAFIFSFWYLDQ LGMAATYNTKSYCRQSLIGGNYGLLNTTTYVPNPDYYSALLWHQLMGKRVLSTISKGTQYLHAYAHCTKNARGITLLLINFSRDTRISVQLSATGIFPEE MNTVLKFSNARGLNNLIASTRNQRSRLEYHLTAKDGNLHSQTMLLNGKILDVTPEGEIPSLEPVTVDADRRISVAPLSIAFVSLP | |||
| Full Sequence |
|---|
| Protein Sequence Length: 554 Download |
| MEYLGSPVRL WIWTVAYLVV MLWNHHIGIG IALCEVNRGF NKTVIAKIWV KGDIGIGETE 60 EDFICATLDW WPPNKCDYGT CSWGNASLLN LNLENPLLVN AVKAFDPLKI RLGGTLQDKV 120 IYHVGDLKQP CHPFVKDESL MFGFTNGCLL MSRWDALNDF FNKTGAVLAF GLNALIGRKR 180 MPNGVMGGRW DSSNARDFIQ YTVDHGYKIN AWELGNELSG SGVGTSISSK QYAADVIELD 240 KILKQIYKDF QEKPLLVAPD GFFEADWFKE VVQKTGPNIL NVVTHHIYNL GAGVDEHLVD 300 KILDPSYLSR EASTFKSLKA ILQRYGPWSS AWVGEAGGAY NSGHNLVTNA FIFSFWYLDQ 360 LGMAATYNTK SYCRQSLIGG NYGLLNTTTY VPNPDYYSAL LWHQLMGKRV LSTISKGTQY 420 LHAYAHCTKN ARGITLLLIN FSRDTRISVQ LSATGIFPEE MNTVLKFSNA RGLNNLIAST 480 RNQRSRLEYH LTAKDGNLHS QTMLLNGKIL DVTPEGEIPS LEPVTVDADR RISVAPLSIA 540 FVSLPYVQLP ACSS 600 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 9.0e-180 | 46 | 362 | 317 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI25561.1 | 0 | 39 | 552 | 23 | 532 | unnamed protein product [Vitis vinifera] |
| GenBank | EAY99897.1 | 0 | 39 | 553 | 20 | 525 | hypothetical protein OsI_21892 [Oryza sativa Indica Group] |
| GenBank | EAZ36024.1 | 0 | 39 | 553 | 20 | 525 | hypothetical protein OsJ_20330 [Oryza sativa Japonica Group] |
| RefSeq | XP_002283254.1 | 0 | 46 | 553 | 38 | 537 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002324603.1 | 0 | 48 | 553 | 3 | 506 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.000003 | 72 | 471 | 36 | 425 | A Chain A, Pectin Methylesterase Pema From Erwinia Chrysanthemi |
| PDB | 3vnz_A | 0.000003 | 72 | 471 | 36 | 425 | A Chain A, Pectin Methylesterase Pema From Erwinia Chrysanthemi |
| PDB | 3vny_A | 0.000003 | 72 | 471 | 36 | 425 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
| Hydropathy |
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| EST Download unfiltered results here | ||||
|---|---|---|---|---|
| Hit | Length | Start | End | EValue |
| EX427870 | 279 | 211 | 489 | 0 |
| DR510683 | 290 | 13 | 302 | 0 |
| GW751521 | 285 | 220 | 503 | 0 |
| GR954550 | 263 | 230 | 492 | 0 |
| GW754509 | 271 | 275 | 544 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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