Basic Information | |
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Species | Picea abies |
Cazyme ID | MA_10435476g0010 |
Family | GT65 |
Protein Properties | Length: 366 Molecular Weight: 41324.2 Isoelectric Point: 9.9728 |
View CDS |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT65 | 159 | 327 | 1.4013e-45 |
VSRVVSKLKSLSSPTGIDYNKIRMSPFMFQPKYVAVHMRIEKDWMIHCKKLEMRSKARNGKDLRICSSKEEIMKRVANIPGLEKPSVVYLAVADDLLEDK TLLEGWSGFLAPYEKKKLGVLDIYSKYPYLIQSAIDYEVCLQADTFVGNSFSTFSSLIVLQRSMRINKA |
Full Sequence |
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Protein Sequence Length: 366 Download |
MSATPPFASP PLMSRLLQIN KTKTSCTTNA AKTKKEEERS SSVGDTAGFV RVMVYRWVLL 60 LFSCLLLSRF LMLTQLRDIG RAYYQWTPDP TSSRLMKPEA GVRDDKFVEV PQIVWGLNNQ 120 KIALARAALT ARKLNRTLLM PNLSASLFYK ETDLLEPLVS RVVSKLKSLS SPTGIDYNKI 180 RMSPFMFQPK YVAVHMRIEK DWMIHCKKLE MRSKARNGKD LRICSSKEEI MKRVANIPGL 240 EKPSVVYLAV ADDLLEDKTL LEGWSGFLAP YEKKKLGVLD IYSKYPYLIQ SAIDYEVCLQ 300 ADTFVGNSFS TFSSLIVLQR SMRINKARDC EGSTMASYAY NIEGPAGGPK RWATNMSDLS 360 LAAISY |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
cd11302 | O-FucT-1 | 0.0002 | 190 | 320 | 147 | + GDP-fucose protein O-fucosyltransferase 1. The protein O-fucosyltransferase 1 (Ofut1 or O-FucT-1) adds O-fucose to EGF (epidermal growth factor-like) repeats. The O-fucsosylation of the Notch receptor signaling protein is dependent on this enzyme, which requires GDP-fucose as a substrate. O-fucose residues added to the target of O-FucT-1 may be further elongated by other glycosyltransferases. On top of O-fucosylation, O-FucT-1 may have other functions such as the regulation of the Notch receptor exit from the ER. Six highly conserved cysteines are present in O-FucT-1, which is a soluble ER protein, as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The membrane-bound pre-protein is released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. O-FucT-1 is similar to family 1 glycosyltransferases (GT1). | ||
cd11299 | O-FucT_plant | 1.0e-5 | 190 | 320 | 141 | + GDP-fucose protein O-fucosyltransferase, plant specific subfamily. Some members of this plant-specific family of O-fucosyltransferases have been annotated as auxin-independent growth promotors. The function of the protein seems unclear. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
pfam10250 | O-FucT | 2.0e-15 | 190 | 320 | 151 | + GDP-fucose protein O-fucosyltransferase. This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. | ||
cd11296 | O-FucT_like | 2.0e-23 | 189 | 323 | 138 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | ABR16519.1 | 0 | 13 | 158 | 1 | 146 | unknown [Picea sitchensis] |
GenBank | ABR16519.1 | 0 | 152 | 366 | 241 | 455 | unknown [Picea sitchensis] |
GenBank | ABR17213.1 | 0 | 53 | 158 | 1 | 106 | unknown [Picea sitchensis] |
GenBank | ABR17213.1 | 0 | 152 | 366 | 201 | 415 | unknown [Picea sitchensis] |
EMBL | CAE30295.1 | 0 | 152 | 366 | 222 | 436 | GDP-fucose protein-O-fucosyltransferase 1 [Pinus taeda] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3zy6_A | 0.002 | 191 | 320 | 213 | 344 | A Chain A, Structure Of Ugt78g1 Complexed With Myricetin And Udp |
PDB | 3zy5_A | 0.002 | 191 | 320 | 213 | 344 | A Chain A, Structure Of Ugt78g1 Complexed With Myricetin And Udp |
PDB | 3zy4_A | 0.002 | 191 | 320 | 213 | 344 | A Chain A, Structure Of Ugt78g1 Complexed With Myricetin And Udp |
PDB | 3zy3_B | 0.002 | 191 | 320 | 213 | 344 | A Chain A, Structure Of Ugt78g1 Complexed With Myricetin And Udp |
PDB | 3zy3_A | 0.002 | 191 | 320 | 213 | 344 | A Chain A, Structure Of Ugt78g1 Complexed With Myricetin And Udp |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
EX330388 | 195 | 172 | 366 | 0 |
EX442351 | 195 | 172 | 366 | 0 |
GO368489 | 195 | 172 | 366 | 0 |
CO483934 | 195 | 172 | 366 | 0 |
DR578460 | 172 | 195 | 366 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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