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Basic Information | |
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Species | Picea abies |
Cazyme ID | MA_110168g0010 |
Family | GH31 |
Protein Properties | Length: 818 Molecular Weight: 90976.6 Isoelectric Point: 4.9612 |
View CDS |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH31 | 222 | 698 | 0 |
FYFFSGPSPLAVVQQYTALIGRPAPMPYWSFGFHQCRYGYKNISDVESVVAGYATAKIPLEAIWTDIDYMDGYKDFTLDPVNFPEKEMQNFVERIHANGQ KYVLIIDPGISVNETYKTFQRGMQDDIFVKQGGVPYLAQVWPGPVYFPDFLNPKTQSFWTKEVSEFYDTIAFDGLWLDMNEVSNFCSGITCSLPNDGNCP RQGAQTDCCLVCSDANTTRWDDPPYQINSAGGHRQLGIKTIAASAVHYNDTLEYNAHNLYGLSEAIVTNKALKSVLKKRPFILTRSTFVGLGAHAAHWTG DNAATWNDLSYSIPTMLSFGLFGVPMIGADICGFLRETNEELCNRWIQLGSFYPFSRDHSDKSKSRQELYLWESVTTSAKKALAHTNGSPIARPLFFTFP EDNNTLGISTQFLLGKGVLVSPVLSQGAVTVDAYFPKGTWYNLFNVPDWITVENGSYVTLEAPLDTINVHVYEGTIL |
Full Sequence |
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Protein Sequence Length: 818 Download |
MISNISEAPD GKSMRAQLQL ILNNSLYGSD IQSLQLLVRY ESNDSLRVYI TDAKQQRWEV 60 PGDILPRYGG VNISEGSKNH LHELLFTYSN NPFGFAITRR SSGETLFNST VNNNGDLFGN 120 MVFKDQYLEV STALPSAASL YGLGESTRQG FPLNGNQNYT LWNSDIGSMN TNLDLYGSHP 180 FYMDVRAGGV AHGVLLLNSN GMDVQYAGSF LTYRANGGVL DFYFFSGPSP LAVVQQYTAL 240 IGRPAPMPYW SFGFHQCRYG YKNISDVESV VAGYATAKIP LEAIWTDIDY MDGYKDFTLD 300 PVNFPEKEMQ NFVERIHANG QKYVLIIDPG ISVNETYKTF QRGMQDDIFV KQGGVPYLAQ 360 VWPGPVYFPD FLNPKTQSFW TKEVSEFYDT IAFDGLWLDM NEVSNFCSGI TCSLPNDGNC 420 PRQGAQTDCC LVCSDANTTR WDDPPYQINS AGGHRQLGIK TIAASAVHYN DTLEYNAHNL 480 YGLSEAIVTN KALKSVLKKR PFILTRSTFV GLGAHAAHWT GDNAATWNDL SYSIPTMLSF 540 GLFGVPMIGA DICGFLRETN EELCNRWIQL GSFYPFSRDH SDKSKSRQEL YLWESVTTSA 600 KKALAHTNGS PIARPLFFTF PEDNNTLGIS TQFLLGKGVL VSPVLSQGAV TVDAYFPKGT 660 WYNLFNVPDW ITVENGSYVT LEAPLDTINV HVYEGTILPM QEIGMTTRES RKSPFSLVVA 720 LGGRMEAYGD LYVDSGEDLE MVIERGKSSY IKFYADTVEG GVRLRSEVQM GEYAIGEGWL 780 LENITVLGTS SSVQRIPVTS KVSLPVGKNF ELVIPWKK 840 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam01055 | Glyco_hydro_31 | 1.0e-84 | 223 | 411 | 189 | + Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases. | ||
cd06602 | GH31_MGAM_SI_GAA | 1.0e-92 | 242 | 406 | 169 | + This family includes the following three closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), and lysosomal acid alpha-glucosidase (GAA), also known as acid-maltase. MGAM is one of the two enzymes responsible for catalyzing the last glucose-releasing step in starch digestion. SI is implicated in the digestion of dietary starch and major disaccharides such as sucrose and isomaltose, while GAA degrades glycogen in the lysosome, cleaving both alpha-1,4 and alpha-1,6 glucosidic linkages. MGAM and SI are anchored to small-intestinal brush-border epithelial cells. The absence of SI from the brush border membrane or its malfunction is associated with malabsorption disorders such as congenital sucrase-isomaltase deficiency (CSID). The domain architectures of MGAM and SI include two tandem GH31 catalytic domains, an N-terminal domain found near the membrane-bound end, and a C-terminal luminal domain. Both of the tandem GH31 domains of MGAM and SI are included in this family. The domain architecture of GAA includes an N-terminal TFF (trefoil factor family) domain in addition to the GH31 catalytic domain. Deficient GAA expression causes pompe disease, an autosomal recessive genetic disorder also known as glycogen storage disease type II (GSDII). | ||
pfam01055 | Glyco_hydro_31 | 3.0e-94 | 467 | 698 | 252 | + Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases. | ||
cd06604 | GH31_glucosidase_II_MalA | 6.0e-103 | 242 | 604 | 366 | + Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized in Bacillus thermoamyloliquefaciens where it forms a homohexamer. This family also includes the MalA alpha-glucosidase from Sulfolobus sulfataricus and the AglA alpha-glucosidase from Picrophilus torridus. MalA is part of the carbohydrate-metabolizing machinery that allows this organism to utilize carbohydrates, such as maltose, as the sole carbon and energy source. | ||
COG1501 | COG1501 | 9.0e-121 | 79 | 763 | 713 | + Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism] |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | AAL40352.1 | 0 | 2 | 792 | 34 | 850 | AF448201_1 putative alpha-xylosidase [Pinus pinaster] |
GenBank | ABR16166.1 | 0 | 2 | 792 | 31 | 847 | unknown [Picea sitchensis] |
RefSeq | XP_002282429.1 | 0 | 4 | 792 | 37 | 856 | PREDICTED: hypothetical protein isoform 1 [Vitis vinifera] |
RefSeq | XP_002457434.1 | 0 | 2 | 788 | 42 | 854 | hypothetical protein SORBIDRAFT_03g007230 [Sorghum bicolor] |
RefSeq | XP_002531635.1 | 0 | 5 | 792 | 44 | 863 | alpha-glucosidase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3w38_A | 0 | 11 | 794 | 57 | 856 | A Chain A, Characterization And Engineering Of The Bifunctional N- And O-glucosyltransferase Involved In Xenobiotic Metabolism In Plants |
PDB | 3w37_A | 0 | 11 | 794 | 57 | 856 | A Chain A, Characterization And Engineering Of The Bifunctional N- And O-glucosyltransferase Involved In Xenobiotic Metabolism In Plants |
PDB | 3ctt_A | 0 | 16 | 789 | 67 | 821 | A Chain A, Characterization And Engineering Of The Bifunctional N- And O-glucosyltransferase Involved In Xenobiotic Metabolism In Plants |
PDB | 2qmj_A | 0 | 16 | 789 | 67 | 821 | A Chain A, Characterization And Engineering Of The Bifunctional N- And O-glucosyltransferase Involved In Xenobiotic Metabolism In Plants |
PDB | 2qly_A | 0 | 16 | 789 | 67 | 821 | A Chain A, Crystral Structure Of The N-Terminal Subunit Of Human Maltase- Glucoamylase |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
HO795307 | 603 | 206 | 788 | 0 |
HO777477 | 521 | 2 | 503 | 0 |
DY272797 | 346 | 234 | 578 | 0 |
HO777477 | 20 | 515 | 534 | 5.1 |
HO777477 | 16 | 498 | 513 | 5.1 |
Sequence Alignments (This image is cropped. Click for full image.) |
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