| Basic Information | |
|---|---|
| Species | Picea abies |
| Cazyme ID | MA_147482g0030 |
| Family | AA3 |
| Protein Properties | Length: 641 Molecular Weight: 71975.6 Isoelectric Point: 8.6665 |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| AA3 | 47 | 598 | 0 |
| IVGAVVANRLSENPSVKVLLLEAGGYENWQSEIPIMASRLQMTNQDWQYYTEPQKHSCFALKENRSRWPRGKVLGGSSTLNYMLYVRGNKRDYDLWKSLG NYGWSWDDVFPYFVKSEDNRDPDILKNGYHGHGGPLTVSTPHYTTPIGGAFIEAGKKFGYPNIDINGEQQTGFAIPQGTIRRGARCSTSKAFLRDIRGQR PNLHVLIWAQATRVLFDSNKRAIGVEFNRRGILHQVLAKREVILSAGAVNSPQLLMLSGIGPAEHLIQLGIPVIHHSPGVGENLQDHIGTGGLHFLTKAP VTVVMPRVYVAKSFTQFSTLGIGPLTMLGGLDGLGFIQTKYANASDDWPDVEIHFIPSCPSSDGGEAVRKAMGMRDEVYDQAYIPHLYDDAYSYYPVLLR PKSTGYIKLRSRNPYDMPIIQPNYLSHPEDVAVLVDALKLSIKMGMSQPFEKFQPKIWDRLWYGCEKYPPYGDLYLECLTRSYTATIYHPVGTAKMGPSD DPYAVVDPELRVYGVKGLRVIDASVMPKIVSGNTNAPIIMIGEKGADLIKGH | |||
| Full Sequence |
|---|
| Protein Sequence Length: 641 Download |
| MWPHNLYDAW LLSLPALVPY MILMSLKMME RKTPFTSETF LHEYDYIVGA VVANRLSENP 60 SVKVLLLEAG GYENWQSEIP IMASRLQMTN QDWQYYTEPQ KHSCFALKEN RSRWPRGKVL 120 GGSSTLNYML YVRGNKRDYD LWKSLGNYGW SWDDVFPYFV KSEDNRDPDI LKNGYHGHGG 180 PLTVSTPHYT TPIGGAFIEA GKKFGYPNID INGEQQTGFA IPQGTIRRGA RCSTSKAFLR 240 DIRGQRPNLH VLIWAQATRV LFDSNKRAIG VEFNRRGILH QVLAKREVIL SAGAVNSPQL 300 LMLSGIGPAE HLIQLGIPVI HHSPGVGENL QDHIGTGGLH FLTKAPVTVV MPRVYVAKSF 360 TQFSTLGIGP LTMLGGLDGL GFIQTKYANA SDDWPDVEIH FIPSCPSSDG GEAVRKAMGM 420 RDEVYDQAYI PHLYDDAYSY YPVLLRPKST GYIKLRSRNP YDMPIIQPNY LSHPEDVAVL 480 VDALKLSIKM GMSQPFEKFQ PKIWDRLWYG CEKYPPYGDL YLECLTRSYT ATIYHPVGTA 540 KMGPSDDPYA VVDPELRVYG VKGLRVIDAS VMPKIVSGNT NAPIIMIGEK GADLIKGHLK 600 YPDPRLKPGN AELPYYLTLP EHEQAKYANG PMSKLGKFFQ G |
| Functional Domains Download unfiltered results here | ||||||
|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description |
| pfam05199 | GMC_oxred_C | 2.0e-47 | 447 | 591 | 145 | + GMC oxidoreductase. This domain found associated with pfam00732. |
| pfam00732 | GMC_oxred_N | 8.0e-48 | 114 | 333 | 230 | + GMC oxidoreductase. This family of proteins bind FAD as a cofactor. |
| TIGR01810 | betA | 5.0e-129 | 45 | 597 | 570 | + choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli , Staphylococcus xylosus , and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified [Cellular processes, Adaptations to atypical conditions]. |
| COG2303 | BetA | 8.0e-135 | 43 | 598 | 572 | + Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism] |
| PRK02106 | PRK02106 | 2.0e-174 | 42 | 616 | 604 | + choline dehydrogenase; Validated |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| RefSeq | XP_001601943.1 | 0 | 14 | 596 | 22 | 612 | PREDICTED: similar to ENSANGP00000015190 [Nasonia vitripennis] |
| RefSeq | XP_001848849.1 | 0 | 11 | 596 | 49 | 642 | glucose dehydrogenase [Culex quinquefasciatus] |
| RefSeq | XP_310333.6 | 0 | 34 | 596 | 72 | 641 | AGAP003784-PA [Anopheles gambiae str. PEST] |
| RefSeq | XP_394224.1 | 0 | 14 | 596 | 22 | 612 | PREDICTED: similar to CG9503-PA [Apis mellifera] |
| RefSeq | XP_972126.1 | 0 | 13 | 596 | 25 | 611 | PREDICTED: similar to alcohol dehydrogenase [Tribolium castaneum] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2jbv_B | 0 | 43 | 596 | 13 | 527 | A Chain A, Crystal Structure Of Choline Oxidase Reveals Insights Into The Catalytic Mechanism |
| PDB | 2jbv_A | 0 | 43 | 596 | 13 | 527 | A Chain A, Crystal Structure Of Choline Oxidase Reveals Insights Into The Catalytic Mechanism |
| PDB | 3nne_H | 0 | 43 | 596 | 13 | 527 | A Chain A, Crystal Structure Of Choline Oxidase S101a Mutant |
| PDB | 3nne_G | 0 | 43 | 596 | 13 | 527 | A Chain A, Crystal Structure Of Choline Oxidase S101a Mutant |
| PDB | 3nne_F | 0 | 43 | 596 | 13 | 527 | A Chain A, Crystal Structure Of Choline Oxidase S101a Mutant |
