| Basic Information | |
|---|---|
| Species | Picea abies |
| Cazyme ID | MA_269826g0010 |
| Family | GH79 |
| Protein Properties | Length: 298 Molecular Weight: 33028.5 Isoelectric Point: 9.7214 |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 168 | 298 | 2.6e-31 |
| TKHINIPAEKYSADVIDLHGILKEVYKNQIAKPLLFASNGYFDADWFKDLIQRTGPKILDVVTHHIYNLGAGVDKSLVEKILDPSFLSQEASTFKSLQSI LKNYGPWEKAWVGESGGAYNSGRNLVTNDFV | |||
| Full Sequence |
|---|
| Protein Sequence Length: 298 Download |
| MEDKEPSTVD AKMQTKVWVE SISLCSLSSQ YDNNVGMKLL TKMGYKGGGI GINGQGVTQP 60 LEVVQRPPFA GLGYDKVDIG ECSKTVKARA TSTSLDSNRG AKAASPHQIC NKDKPGRYKS 120 HSNSFLEFKK NDYGHRSSNH DVAKDHMKKF WVKKTYVSTV KGKSSKETKH INIPAEKYSA 180 DVIDLHGILK EVYKNQIAKP LLFASNGYFD ADWFKDLIQR TGPKILDVVT HHIYNLGAGV 240 DKSLVEKILD PSFLSQEAST FKSLQSILKN YGPWEKAWVG ESGGAYNSGR NLVTNDFV 300 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 2.0e-59 | 175 | 298 | 124 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ABR16706.1 | 0 | 173 | 298 | 77 | 202 | unknown [Picea sitchensis] |
| GenBank | ACR36272.1 | 3e-39 | 173 | 298 | 221 | 346 | unknown [Zea mays] |
| GenBank | EAY99897.1 | 3e-39 | 173 | 298 | 208 | 333 | hypothetical protein OsI_21892 [Oryza sativa Indica Group] |
| GenBank | EAZ36024.1 | 3e-39 | 173 | 298 | 208 | 333 | hypothetical protein OsJ_20330 [Oryza sativa Japonica Group] |
| RefSeq | NP_001056967.1 | 3e-39 | 173 | 298 | 209 | 334 | Os06g0179000 [Oryza sativa (japonica cultivar-group)] |
| Hydropathy |
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| EST Download unfiltered results here | ||||
|---|---|---|---|---|
| Hit | Length | Start | End | EValue |
| EX427870 | 127 | 172 | 298 | 0 |
| EX428547 | 126 | 173 | 298 | 0 |
| GW751521 | 127 | 172 | 298 | 0 |
| GW763904 | 126 | 173 | 298 | 0 |
| EX309526 | 122 | 177 | 298 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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