y
Basic Information | |
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Species | Picea abies |
Cazyme ID | MA_343625g0010 |
Family | GH79 |
Protein Properties | Length: 165 Molecular Weight: 18647.6 Isoelectric Point: 5.1962 |
View CDS |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 48 | 158 | 4.3e-31 |
DQDFICATLDWWPPNKCDYGTCSWGNASLLNLDLENPLLANAVKAFHPWKIRLGGSLQDKIIYDVGKLKQACPPFVKNESLIFGFSNGCLSMSKWDALNA LFNKTGYAIEF |
Full Sequence |
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Protein Sequence Length: 165 Download |
MVYSVFRLWF WTLVLCANEI RCENSFNKTA IAKVRVLVDG EFAVAETDQD FICATLDWWP 60 PNKCDYGTCS WGNASLLNLD LENPLLANAV KAFHPWKIRL GGSLQDKIIY DVGKLKQACP 120 PFVKNESLIF GFSNGCLSMS KWDALNALFN KTGYAIEFTS ELFLV 180 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 3.0e-57 | 36 | 158 | 123 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | ACJ85786.1 | 0 | 11 | 158 | 15 | 161 | unknown [Medicago truncatula] |
GenBank | EAY99897.1 | 0 | 38 | 158 | 31 | 151 | hypothetical protein OsI_21892 [Oryza sativa Indica Group] |
GenBank | EAZ36024.1 | 0 | 38 | 158 | 31 | 151 | hypothetical protein OsJ_20330 [Oryza sativa Japonica Group] |
RefSeq | XP_002283254.1 | 0 | 6 | 158 | 10 | 162 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002283260.1 | 0 | 8 | 158 | 12 | 162 | PREDICTED: hypothetical protein [Vitis vinifera] |