| Basic Information | |
|---|---|
| Species | Picea abies |
| Cazyme ID | MA_93036g0010 |
| Family | GH79 |
| Protein Properties | Length: 488 Molecular Weight: 54612.1 Isoelectric Point: 9.1461 |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 317 | 479 | 1.5e-35 |
| ALLWHRLMGRGVLSVNITGPPYVRTYAHCAKNDYLTPVYFFLQTGITLLLINLSNDTNVDILVSSFPNSTMYKRIPNAKESFVHKIRKFLAWAGSKTSEV KHYRMEYHLTPKDGDLHSQTVLLNGAVLELTEDGDIPSLDPVMVDAGIPISVAPLSIAFVSLP | |||
| GH79 | 60 | 248 | 0 |
| DEHFICATLDWWPPEKCDNFGRCSWINASLLNLDLENPIFAKAIKAFSPLKVRLGGTLQDKLIYDVGPLSQPCDPFVRNHSKMFGFSKGCLTMDRWDKLN KFFARTGCMVAFGLNALYGRHKMMHKLLWGGRWNSSNARNFIQYTVDHGYKIYAWEFGNELSGSGIGARVYATQYAADVIELNKILKDI | |||
| Full Sequence |
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| Protein Sequence Length: 488 Download |
| MNVALDKKFV VGWKAYALRH KKNCIVLEKS AIVVFCCVNA CNGQSVTLVV NASAKIAETD 60 EHFICATLDW WPPEKCDNFG RCSWINASLL NLDLENPIFA KAIKAFSPLK VRLGGTLQDK 120 LIYDVGPLSQ PCDPFVRNHS KMFGFSKGCL TMDRWDKLNK FFARTGCMVA FGLNALYGRH 180 KMMHKLLWGG RWNSSNARNF IQYTVDHGYK IYAWEFGNEL SGSGIGARVY ATQYAADVIE 240 LNKILKDIYK NSRSDNHLTQ KILSPGYLSR EATKFRQMQA ILQKYGPWSS SWVGEAGGSY 300 NSGKHRVSDA FVNSFCALLW HRLMGRGVLS VNITGPPYVR TYAHCAKNDY LTPVYFFLQT 360 GITLLLINLS NDTNVDILVS SFPNSTMYKR IPNAKESFVH KIRKFLAWAG SKTSEVKHYR 420 MEYHLTPKDG DLHSQTVLLN GAVLELTEDG DIPSLDPVMV DAGIPISVAP LSIAFVSLPG 480 LDISACLQ 540 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 5.0e-141 | 43 | 325 | 325 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACG44916.1 | 0 | 45 | 486 | 27 | 540 | heparanase-like protein 2 precursor [Zea mays] |
| GenBank | ACR10240.1 | 0 | 46 | 486 | 25 | 537 | heparanase [Oryza sativa Indica Group] |
| RefSeq | NP_001067122.1 | 0 | 46 | 486 | 25 | 537 | Os12g0578400 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | NP_001145968.1 | 0 | 45 | 486 | 27 | 540 | hypothetical protein LOC100279495 [Zea mays] |
| RefSeq | XP_002284470.1 | 0 | 44 | 486 | 23 | 538 | PREDICTED: hypothetical protein [Vitis vinifera] |
| Hydropathy |
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| EST Download unfiltered results here | ||||
|---|---|---|---|---|
| Hit | Length | Start | End | EValue |
| CX647951 | 266 | 95 | 318 | 0 |
| EX933244 | 259 | 66 | 282 | 0 |
| ES860078 | 235 | 296 | 488 | 0 |
| EX390283 | 242 | 241 | 439 | 0 |
| EX390283 | 28 | 439 | 466 | 0.0003 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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