| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000088659 |
| Family | GH79 |
| Protein Properties | Length: 629 Molecular Weight: 69994.8 Isoelectric Point: 9.4047 |
| Chromosome | Chromosome/Scaffold: 01644660 Start: 5234 End: 9439 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 50 | 535 | 0 |
| DDDFICATLDWWPPEKCDYGTCSWGRASLLNLDLKNTILLNAIKAFSPLKLRLGGTLQDKVIYATPDNKQSCNAFRKSTSEMFGFTQGCLPMRRWDELSS FFQKAGAKIIFGLNALTGRTINSNGTATGAWDYTNSESFIRYNVKNNYTVHGWELGNELCGHGIGTTISASQYVSDTTALQKIVQDIYKGVEPKPLILSP GGFFDANWFKDYTDKTTTSLDVVTHHIYNLGPGVDQHLIEKILDPSVLDGISSTFRNLRGILKGSTTSAAAWVGEAGGAYNSGRNLVSNTFVYSFWYLDQ LGMSATYDTKTYCRQTLIGGNYGLLNTTTFEPNPDYYSALLWHRLMGRNVLATSFSGPKKIRAYAHCAKQSKGITVLLINLHNTTAIEARVAFNATWTLR HKHKSHKLHRSHVAKLRQGLESSTEREEYHLTAKDGXIQSQTMLLNGNALRVDSSGTIPSLNPVYVNASEPIVVGPSSIVFAHIPY | |||
| Full Sequence |
|---|
| Protein Sequence Length: 629 Download |
| MGSDIWQMGF IFWVFFGFLV CSVNAKVGFG GGSVEGTVRI NGRDAIGKID DDFICATLDW 60 WPPEKCDYGT CSWGRASLLN LDLKNTILLN AIKAFSPLKL RLGGTLQDKV IYATPDNKQS 120 CNAFRKSTSE MFGFTQGCLP MRRWDELSSF FQKAGAKIIF GLNALTGRTI NSNGTATGAW 180 DYTNSESFIR YNVKNNYTVH GWELGNELCG HGIGTTISAS QYVSDTTALQ KIVQDIYKGV 240 EPKPLILSPG GFFDANWFKD YTDKTTTSLD VVTHHIYNLG PGVDQHLIEK ILDPSVLDGI 300 SSTFRNLRGI LKGSTTSAAA WVGEAGGAYN SGRNLVSNTF VYSFWYLDQL GMSATYDTKT 360 YCRQTLIGGN YGLLNTTTFE PNPDYYSALL WHRLMGRNVL ATSFSGPKKI RAYAHCAKQS 420 KGITVLLINL HNTTAIEARV AFNATWTLRH KHKSHKLHRS HVAKLRQGLE SSTEREEYHL 480 TAKDGXIQSQ TMLLNGNALR VDSSGTIPSL NPVYVNASEP IVVGPSSIVF AHIPYVVPPA 540 CRTLNRDYNN KKVSLXSKRX EAYCWQTPTK RLYHLNFDCS VPDNAKLERA KPPVRIPTTS 600 QWGNPRSTEE RVMQAAGDKK AIVWQIFRT 660 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 34 | 351 | 319 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAN81917.1 | 0 | 1 | 629 | 1 | 636 | hypothetical protein [Vitis vinifera] |
| EMBL | CBI25561.1 | 0 | 8 | 542 | 1 | 533 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002263173.1 | 0 | 1 | 542 | 5 | 559 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002324603.1 | 0 | 36 | 541 | 1 | 505 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002533671.1 | 0 | 8 | 542 | 1 | 551 | heparanase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.000001 | 62 | 405 | 36 | 371 | A Chain A, Structure Of The Gh47 Processing Alpha-1,2-mannosidase From Caulobacter Strain K31 |
| PDB | 3vnz_A | 0.000001 | 62 | 405 | 36 | 371 | A Chain A, Structure Of The Gh47 Processing Alpha-1,2-mannosidase From Caulobacter Strain K31 |
| PDB | 3vny_A | 0.000001 | 62 | 405 | 36 | 371 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
