Basic Information | |
---|---|
Species | Malus domestica |
Cazyme ID | MDP0000126058 |
Family | GH18 |
Protein Properties | Length: 1145 Molecular Weight: 125964 Isoelectric Point: 8.1075 |
Chromosome | Chromosome/Scaffold: 011098269 Start: 9108 End: 19574 |
Description | Glycosyl hydrolase superfamily protein |
View CDS |
External Links |
---|
NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
---|---|---|---|
Family | Start | End | Evalue |
GH18 | 181 | 427 | 3.2e-34 |
ELLTKKKQRSKAINLIVNECKEMRYDGIVLESWSRWAAYRILHDPSLRNLALQFIKELGDALHGVSLERNDKQRLQLVYVIGPPHSEKLQPHDFGPKDLQ SLDDAVDGFSLMTYDFSGPNNPGPNAPLKWIHSTXQLLLGTNKNSALACKIFLGINFYGNDFVLTGGPGGGAITGRDYLSLLEKHKPELEWEKNSAEHLF FYSDDESNYHAVFYPSPMSISVRLEEARKWGCGISIWEIGQEFLKTS |
Full Sequence |
---|
Protein Sequence Length: 1145 Download |
MAKKRERRVA PSSNRGEDRV EPSGQLRDAN GQHIVTFVLF FCVAVATAVL AYRIKYAPTA 60 XPTNYAVYER GIVKPDVNYQ EILTARKWKG FRKYEWQALC ISCIGLHYSM DYFLAVGVGD 120 NPLIYDLQPL EIVGISVKIH QGNSLILEGR HNADMGWISD LRMAGDAWVL PRVVLEAFPA 180 ELLTKKKQRS KAINLIVNEC KEMRYDGIVL ESWSRWAAYR ILHDPSLRNL ALQFIKELGD 240 ALHGVSLERN DKQRLQLVYV IGPPHSEKLQ PHDFGPKDLQ SLDDAVDGFS LMTYDFSGPN 300 NPGPNAPLKW IHSTXQLLLG TNKNSALACK IFLGINFYGN DFVLTGGPGG GAITGRDYLS 360 LLEKHKPELE WEKNSAEHLF FYSDDESNYH AVFYPSPMSI SVRLEEARKW GCGISIWEIG 420 QEFLKTSSDI FLSHTKHLQP KVIIPAIRQY QVINNLAILT RHNYAMEAFN AASLTPIRSV 480 LGDRRKIPSL PSISLPKFSH PTGLKASQES SSRSFHGGLL LLSSVFNAGF AKALSNEEAL 540 GQTVSGGGGD LEVGGVLDSV ISFVTDNPAV VAGGFAVLAV PLILSQVLKP PKPFGVDSAR 600 SAYAKLGEEA NAQLLDIRSP ADFRQFGTPD VKGLGKKAVS IVYKGEDKPG FLKKLSLKFK 660 EPENTTLFIL DKDHYLDGER KIQFTLPFSF EEDGGVENSH IKTQLLLICE ANPANVLMEA 720 RFDENSELVA ELVTVNGFKA AYAIKDGAEG PRGWVNSGLP WTPPTKALSF DFGNLTDALN 780 DAVGEGSDTL SLSLGVAAAT GLGLLAFTEL ETILQVLGSA ALVQFASKKL LFAEDRKETL 840 QQVDKFLTTK VAPKELVDDI KQIGTALLPV TVSKALPAPA XPTPEPTAAS DTVQKAEAVV 900 EPKVEAATEA TXEPNSVPKP EVKAESLPGI SKPLSPFPYV DLWVDVIHGP YVLILRLRTL 960 RSRADPIPTV VTVEKKCRLT HVVSYNVQML PLETILXRWL PNNSSGVVLC LTGWSGKFFK 1020 LETISETTSL LTPAKKLLPP PSHQNFNGES QTHRRKKRQE SYSRTNCSLS LQSAGRSSVA 1080 SPAQPESSRS TRRPEANPTS IYVFFIGAGG DDATVEVQER SRRSGVTGQE QWLFGKFVTF 1140 RRQLR |
Functional Domains Download unfiltered results here | ||||||||
---|---|---|---|---|---|---|---|---|
Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam00704 | Glyco_hydro_18 | 6.0e-11 | 180 | 421 | 257 | + Glycosyl hydrolases family 18. | ||
COG3858 | COG3858 | 5.0e-17 | 182 | 423 | 248 | + Predicted glycosyl hydrolase [General function prediction only] | ||
smart00636 | Glyco_18 | 3.0e-21 | 180 | 421 | 270 | + Glyco_18 domain. | ||
cd02874 | GH18_CFLE_spore_hydrolase | 1.0e-23 | 182 | 423 | 252 | + Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the forespore inner membrane and is deposited as a mature enzyme in the cortex layer of the spore. As part of a sensory mechanism capable of initiating germination, CFLE degrades a spore-specific peptidoglycan constituent called muramic-acid delta-lactam that comprises the outer cortex. CFLE has a C-terminal glycosyl hydrolase family 18 (GH18) catalytic domain as well as two N-terminal LysM peptidoglycan-binding domains. In addition to SleB, this family includes YaaH, YdhD, and YvbX from Bacillus subtilis. | ||
cd02876 | GH18_SI-CLP | 2.0e-104 | 141 | 421 | 286 | + Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl hydrolase family 18 (GH18) domain but lacks a chitin-binding domain. The catalytic amino acids of the GH18 domain are not conserved in SI-CLP, similar to the chitolectins YKL-39, YKL-40, and YM1/2. Human SI-CLP is sorted to late endosomes and secretory lysosomes in alternatively activated macrophages. |
Gene Ontology | |
---|---|
GO Term | Description |
GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
GO:0005975 | carbohydrate metabolic process |
Annotations - NR Download unfiltered results here | |||||||
---|---|---|---|---|---|---|---|
Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | AAB61039.1 | 0 | 1 | 880 | 27 | 853 | A_IG002N01.31 gene product [Arabidopsis thaliana] |
EMBL | CBI40499.1 | 0 | 1 | 421 | 1 | 426 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002302622.1 | 0 | 466 | 939 | 1 | 421 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002320856.1 | 0 | 55 | 421 | 27 | 390 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002523373.1 | 0 | 1 | 942 | 1 | 927 | chitinase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
---|---|---|---|---|---|---|---|
Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 2dcq_A | 0 | 599 | 766 | 9 | 127 | A Chain A, Crystal Structure Of Class I Chitinase From Oryza Sativa L. Japonica |
PDB | 1vee_A | 0 | 599 | 766 | 9 | 127 | A Chain A, Nmr Structure Of The Hypothetical Rhodanese Domain At4g01050 From Arabidopsis Thaliana |
PDB | 3bxw_A | 3.00004e-41 | 149 | 421 | 125 | 384 | B Chain B, Crystal Structure Of Stabilin-1 Interacting Chitinase-Like Protein, Si-Clp |
PDB | 3bxw_B | 3.00004e-41 | 149 | 421 | 125 | 384 | B Chain B, Crystal Structure Of Stabilin-1 Interacting Chitinase-Like Protein, Si-Clp |
PDB | 3cz8_B | 0.00001 | 181 | 419 | 88 | 308 | A Chain A, Crystal Structure Of Putative Sporulation-Specific Glycosylase Ydhd From Bacillus Subtilis |