| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000127117 |
| Family | GT47 |
| Protein Properties | Length: 351 Molecular Weight: 40128.9 Isoelectric Point: 8.6747 |
| Chromosome | Chromosome/Scaffold: 012582357 Start: 1256 End: 2311 |
| Description | Exostosin family protein |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
 | |||
| Family | Start | End | Evalue |
| GT47 | 48 | 281 | 9.6e-36 |
| FKIFIYNSNSTFPFTSPSQSLFYTRLQDSHFPTENPEKAHLFFVPFPSDLPPRSVSRLIRSLRTELPYWNRTLGADHFYLSCTGIGYESDRNLVELKKNS VQISCFPTPAGKFIPHKDISLPPVPSTPAPTTNTTSFLGYAKFDWVKESTLVKELSSDPDFLIESKPSDLNTFADRLGGSKFCLFEYGGGDVSGIWEALR FGCVPVVITDRPIHDLPFSDVLRWQEIALFVGRR | |||
| Full Sequence |
|---|
| Protein Sequence Length: 351 Download |
| MSTASILRLL LLHFSLSTVL AAHSQPLTSP YLSPNTIHPN YQNMFNSFKI FIYNSNSTFP 60 FTSPSQSLFY TRLQDSHFPT ENPEKAHLFF VPFPSDLPPR SVSRLIRSLR TELPYWNRTL 120 GADHFYLSCT GIGYESDRNL VELKKNSVQI SCFPTPAGKF IPHKDISLPP VPSTPAPTTN 180 TTSFLGYAKF DWVKESTLVK ELSSDPDFLI ESKPSDLNTF ADRLGGSKFC LFEYGGGDVS 240 GIWEALRFGC VPVVITDRPI HDLPFSDVLR WQEIALFVGR RGGVVTDLKL VLGRACWERH 300 EKMRQLGVAA SRHFMWNETP EPFDSFYTLM YQLWLRRHTV RYVRRESPFV V 360 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03016 | Exostosin | 9.0e-24 | 46 | 281 | 280 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| RefSeq | XP_001753053.1 | 0 | 20 | 345 | 104 | 462 | predicted protein [Physcomitrella patens subsp. patens] |
| RefSeq | XP_002282317.1 | 0 | 2 | 346 | 4 | 358 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002311191.1 | 0 | 9 | 346 | 5 | 343 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002316258.1 | 0 | 9 | 346 | 5 | 337 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002524235.1 | 0 | 34 | 346 | 32 | 335 | conserved hypothetical protein [Ricinus communis] |
