| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000128161 |
| Family | GT47 |
| Protein Properties | Length: 538 Molecular Weight: 60961.9 Isoelectric Point: 8.1668 |
| Chromosome | Chromosome/Scaffold: 013978495 Start: 6241 End: 8916 |
| Description | Exostosin family protein |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GT47 | 206 | 487 | 0 |
| EEKFKVFVYAEGEPPLFHNGPCKSIYSMEGNFIHQIEVNKQFRTRDPEKAHVYFLPFSVTMLVRFVYVRDSHDFSPIRQTVRDYVNIVSEKYPYWNRSLG ADHFMLACHDWGPETSNSNPHLRKNSIRALCNANTSEGFNPSKDVSFPEINLQTGDTHGFLGGPSPRLRSNLAFFAGGVHGPIRPILLEHWENKDPDMRV HQYLPKGVSYYNMMRQSRFCLCPSGYEVASPRVVEAIYTGCVPVLISDHYVPPFSDILNWKSFSVEVSVSDIPNLKKILTSI | |||
| Full Sequence |
|---|
| Protein Sequence Length: 538 Download |
| MGTSSKNLAA ISNSSSTHQR AWWSSSSSIA VLLFVVPLVV VFGLISVLGP NTANWVTISP 60 SASPSLNLTA TSPSSSDSND DVLGLRSTVA VLDMNSIEEA HSDDSVQNRS SSPPIAIEDE 120 AEALPTLQQP NVTNRDDSRN ETYASIMEKR QRKNTNLGLL EARLRRARAA IREAKFGNQT 180 HDVDYIPNGP MYWNANAFHS SYLEMEEKFK VFVYAEGEPP LFHNGPCKSI YSMEGNFIHQ 240 IEVNKQFRTR DPEKAHVYFL PFSVTMLVRF VYVRDSHDFS PIRQTVRDYV NIVSEKYPYW 300 NRSLGADHFM LACHDWGPET SNSNPHLRKN SIRALCNANT SEGFNPSKDV SFPEINLQTG 360 DTHGFLGGPS PRLRSNLAFF AGGVHGPIRP ILLEHWENKD PDMRVHQYLP KGVSYYNMMR 420 QSRFCLCPSG YEVASPRVVE AIYTGCVPVL ISDHYVPPFS DILNWKSFSV EVSVSDIPNL 480 KKILTSISSR QYVRMQRRVL QVRKHFEVNS PPKRFDVFHM ILHSIWLRRL NVRVHDDQ 540 |
| Functional Domains Download unfiltered results here | ||||||
|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description |
| pfam03016 | Exostosin | 2.0e-64 | 205 | 487 | 301 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| DDBJ | BAB08605.1 | 0 | 131 | 536 | 3 | 407 | unnamed protein product [Arabidopsis thaliana] |
| RefSeq | NP_001031828.1 | 0 | 116 | 536 | 98 | 517 | unknown protein [Arabidopsis thaliana] |
| RefSeq | XP_002284018.1 | 0 | 205 | 535 | 1 | 331 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002326234.1 | 0 | 205 | 532 | 1 | 328 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002528630.1 | 0 | 144 | 538 | 175 | 569 | catalytic, putative [Ricinus communis] |
