| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000130742 |
| Family | CE1 |
| Protein Properties | Length: 285 Molecular Weight: 31750.7 Isoelectric Point: 6.7063 |
| Chromosome | Chromosome/Scaffold: 018932192 Start: 945 End: 6291 |
| Description | S-formylglutathione hydrolase |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| CE1 | 26 | 225 | 1.1e-39 |
| LTLGCSMTFHIYFPPSPSLSHRFPVLYWLSGLTCTDENFITKSGAQCVASSEGVALIAPDTSPRGLSIEGEADSWDFGVGARFYLNATQEKWKNWRMYDY VVKELPQLLNEIFSQLDTSRASISGHSMGGHGALTIYLKNLDKYKSVSAFAPIVNPANCPWGQKAFSNYLGGNKTDWEEYDATSLVKKFNDVSATILIDQ | |||
| Full Sequence |
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| Protein Sequence Length: 285 Download |
| METKPNEISR SKMFGGYNKR YKHFSLTLGC SMTFHIYFPP SPSLSHRFPV LYWLSGLTCT 60 DENFITKSGA QCVASSEGVA LIAPDTSPRG LSIEGEADSW DFGVGARFYL NATQEKWKNW 120 RMYDYVVKEL PQLLNEIFSQ LDTSRASISG HSMGGHGALT IYLKNLDKYK SVSAFAPIVN 180 PANCPWGQKA FSNYLGGNKT DWEEYDATSL VKKFNDVSAT ILIDQEIDGI ENAKNIASHA 240 GLTEMVINCI NKCEGCHHAE LYSNILLTXG TTSVPQLKER LQKDV |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam00022 | Actin | 2.0e-9 | 221 | 285 | 65 | + Actin. | ||
| pfam00756 | Esterase | 1.0e-44 | 25 | 213 | 190 | + Putative esterase. This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family. | ||
| COG0627 | COG0627 | 5.0e-61 | 8 | 213 | 223 | + Predicted esterase [General function prediction only] | ||
| TIGR02821 | fghA_ester_D | 3.0e-99 | 8 | 225 | 219 | + S-formylglutathione hydrolase. This model describes a protein family from bacteria, yeast, and human, with a conserved critical role in formaldehyde detoxification as S-formylglutathione hydrolase (EC 3.1.2.12). Members in eukaryotes such as the human protein are better known as esterase D (EC 3.1.1.1), an enzyme with broad specificity, although S-formylglutathione hydrolase has now been demonstrated as well [Cellular processes, Detoxification]. | ||
| PLN02442 | PLN02442 | 3.0e-164 | 1 | 225 | 225 | + S-formylglutathione hydrolase | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0004091 | carboxylesterase activity |
| GO:0016023 | cytoplasmic membrane-bounded vesicle |
| GO:0018738 | S-formylglutathione hydrolase activity |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACJ11734.1 | 0 | 1 | 228 | 1 | 228 | S-formylglutathione hydrolase [Gossypium hirsutum] |
| GenBank | ACU18661.1 | 0 | 1 | 228 | 1 | 228 | unknown [Glycine max] |
| GenBank | ACU19052.1 | 0 | 1 | 228 | 1 | 228 | unknown [Glycine max] |
| RefSeq | XP_002284489.1 | 0 | 1 | 228 | 1 | 228 | PREDICTED: hypothetical protein isoform 1 [Vitis vinifera] |
| RefSeq | XP_002308013.1 | 0 | 1 | 225 | 1 | 225 | esterase d, s-formylglutathione hydrolase [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3fcx_B | 0 | 7 | 228 | 5 | 225 | A Chain A, Crystal Structure Of Human Esterase D |
| PDB | 3fcx_A | 0 | 7 | 228 | 5 | 225 | A Chain A, Crystal Structure Of Human Esterase D |
| PDB | 3s8y_A | 0 | 8 | 228 | 7 | 225 | A Chain A, Bromide Soaked Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| PDB | 3i6y_B | 0 | 8 | 228 | 7 | 225 | A Chain A, Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| PDB | 3i6y_A | 0 | 8 | 228 | 7 | 225 | A Chain A, Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| Hydropathy |
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| EST Download unfiltered results here | ||||
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| Hit | Length | Start | End | EValue |
| GO502842 | 223 | 3 | 225 | 0 |
| CN881070 | 217 | 1 | 217 | 0 |
| FQ424953 | 238 | 1 | 238 | 0 |
| EE064765 | 225 | 1 | 225 | 0 |
| FQ481640 | 228 | 1 | 228 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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| Phylogeny |
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