| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000134637 |
| Family | GH89 |
| Protein Properties | Length: 257 Molecular Weight: 29153.4 Isoelectric Point: 7.2997 |
| Chromosome | Chromosome/Scaffold: 00354729 Start: 619 End: 3168 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 1 | 257 | 0 |
| MIVLDLFADVKPIWKTSSQFYGTPYIWCLLHNFGGNIEMYGILDAISSGPVDARTSENSTMVGVGMCMEGIEHNPVVYELTSEMAFRSEKVQVQDWLKIY SRRRYGNAVPKVEAAWDILHQTIYNCTDGIASFDASMTLSRLKKGKKHNHALAVSGIVIGWTLFDASMALIMFHDHNTDFIVKLPDWDPSPNHISNISKQ NQMQSFIPLDKKRRVLLQKTSSNLPQAHLWYSTQEVVNALRLFLDTGNEFSGSLTYR | |||
| Full Sequence |
|---|
| Protein Sequence Length: 257 Download |
| MIVLDLFADV KPIWKTSSQF YGTPYIWCLL HNFGGNIEMY GILDAISSGP VDARTSENST 60 MVGVGMCMEG IEHNPVVYEL TSEMAFRSEK VQVQDWLKIY SRRRYGNAVP KVEAAWDILH 120 QTIYNCTDGI ASFDASMTLS RLKKGKKHNH ALAVSGIVIG WTLFDASMAL IMFHDHNTDF 180 IVKLPDWDPS PNHISNISKQ NQMQSFIPLD KKRRVLLQKT SSNLPQAHLW YSTQEVVNAL 240 RLFLDTGNEF SGSLTYR |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12972 | NAGLU_C | 7.0e-18 | 95 | 257 | 163 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 7.0e-44 | 1 | 90 | 90 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAA77084.1 | 0 | 1 | 257 | 409 | 627 | alpha-N-acetylglucosaminidase [Nicotiana tabacum] |
| EMBL | CBI24942.1 | 0 | 1 | 257 | 471 | 685 | unnamed protein product [Vitis vinifera] |
| RefSeq | NP_196873.1 | 0 | 1 | 257 | 408 | 622 | alpha-N-acetylglucosaminidase family / NAGLU family [Arabidopsis thaliana] |
| RefSeq | XP_002273084.1 | 0 | 1 | 257 | 406 | 620 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002314048.1 | 0 | 1 | 257 | 410 | 623 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 2e-17 | 2 | 124 | 511 | 631 | A Chain A, The 1.1a Crystallographic Structure Of Ubiquitin- Conjugating Enzyme (Ubc-2) From Caenorhabditis Elegans: Functional And Evolutionary Significa |
| PDB | 2vcb_A | 2e-17 | 2 | 124 | 511 | 631 | A Chain A, The 1.1a Crystallographic Structure Of Ubiquitin- Conjugating Enzyme (Ubc-2) From Caenorhabditis Elegans: Functional And Evolutionary Significa |
| PDB | 2vca_A | 2e-17 | 2 | 124 | 511 | 631 | A Chain A, The 1.1a Crystallographic Structure Of Ubiquitin- Conjugating Enzyme (Ubc-2) From Caenorhabditis Elegans: Functional And Evolutionary Significa |
| PDB | 2vc9_A | 2e-17 | 2 | 124 | 511 | 631 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 4e-17 | 2 | 124 | 534 | 654 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
