| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000134637 |
| Family | GH89 |
| Protein Properties | Length: 257 Molecular Weight: 29153.4 Isoelectric Point: 7.2997 |
| Chromosome | Chromosome/Scaffold: 00354729 Start: 619 End: 3168 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH89 | 1 | 257 | 0 |
| MIVLDLFADVKPIWKTSSQFYGTPYIWCLLHNFGGNIEMYGILDAISSGPVDARTSENSTMVGVGMCMEGIEHNPVVYELTSEMAFRSEKVQVQDWLKIY SRRRYGNAVPKVEAAWDILHQTIYNCTDGIASFDASMTLSRLKKGKKHNHALAVSGIVIGWTLFDASMALIMFHDHNTDFIVKLPDWDPSPNHISNISKQ NQMQSFIPLDKKRRVLLQKTSSNLPQAHLWYSTQEVVNALRLFLDTGNEFSGSLTYR | |||
| Full Sequence |
|---|
| Protein Sequence Length: 257 Download |
| MIVLDLFADV KPIWKTSSQF YGTPYIWCLL HNFGGNIEMY GILDAISSGP VDARTSENST 60 MVGVGMCMEG IEHNPVVYEL TSEMAFRSEK VQVQDWLKIY SRRRYGNAVP KVEAAWDILH 120 QTIYNCTDGI ASFDASMTLS RLKKGKKHNH ALAVSGIVIG WTLFDASMAL IMFHDHNTDF 180 IVKLPDWDPS PNHISNISKQ NQMQSFIPLD KKRRVLLQKT SSNLPQAHLW YSTQEVVNAL 240 RLFLDTGNEF SGSLTYR 300 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12972 | NAGLU_C | 7.0e-18 | 95 | 257 | 163 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 7.0e-44 | 1 | 90 | 90 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAA77084.1 | 0 | 1 | 257 | 409 | 627 | alpha-N-acetylglucosaminidase [Nicotiana tabacum] |
| EMBL | CBI24942.1 | 0 | 1 | 257 | 471 | 685 | unnamed protein product [Vitis vinifera] |
| RefSeq | NP_196873.1 | 0 | 1 | 257 | 408 | 622 | alpha-N-acetylglucosaminidase family / NAGLU family [Arabidopsis thaliana] |
| RefSeq | XP_002273084.1 | 0 | 1 | 257 | 406 | 620 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002314048.1 | 0 | 1 | 257 | 410 | 623 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 2e-17 | 2 | 124 | 511 | 631 | A Chain A, The 1.1a Crystallographic Structure Of Ubiquitin- Conjugating Enzyme (Ubc-2) From Caenorhabditis Elegans: Functional And Evolutionary Significa |
| PDB | 2vcb_A | 2e-17 | 2 | 124 | 511 | 631 | A Chain A, The 1.1a Crystallographic Structure Of Ubiquitin- Conjugating Enzyme (Ubc-2) From Caenorhabditis Elegans: Functional And Evolutionary Significa |
| PDB | 2vca_A | 2e-17 | 2 | 124 | 511 | 631 | A Chain A, The 1.1a Crystallographic Structure Of Ubiquitin- Conjugating Enzyme (Ubc-2) From Caenorhabditis Elegans: Functional And Evolutionary Significa |
| PDB | 2vc9_A | 2e-17 | 2 | 124 | 511 | 631 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 4e-17 | 2 | 124 | 534 | 654 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
