| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000136847 |
| Family | AA3 |
| Protein Properties | Length: 553 Molecular Weight: 60237.8 Isoelectric Point: 9.2618 |
| Chromosome | Chromosome/Scaffold: 004932329 Start: 23478 End: 25777 |
| Description | Glucose-methanol-choline (GMC) oxidoreductase family protein |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| AA3 | 49 | 545 | 0 |
| PLQEKYDYIVVGGGTAGCPLAATLSANYSVLLLERGDIPTAYPNVLSNAGILANFMQEDDGKTPAQRFTSEDGVAFVRGRVLGGSSMINVGLYSRADSEF LKKSGIKLDMNLVNNSYEWVENTLVFRPNLSHWQSVVKDALLEAGVRPDNGLTLDHIQGTKITGTIFDDRGRRHGAVELLNKGHPKNLRVAIHAAVERII FSSKASGLSAKGIIYTDSNGRSHQALIRGKGEVILSAGAIGSPQLLLLSGVGPKSYLSSLKIPVVHPQPYVGQFMRDNPRXYVTILPPSELEPSTAQIAG ITSDYYIETFSGLPFSTMAFSLFPNPTIPMTINSTFGHIVTKNPAPLSYGSLKLQSSYDVKVGPXVKFNYFAXKADLSRCVSAVRKMGDLLKTXXLKPFK XXDLPGEXGFNLFGPPLPMNXSDVASIETFCRDTVATXWHYHGGCLVGKVVDGDFRVRGIKALRVVDGSVFKSLSPGTNPQATLMMLGRHVGLRMLE | |||
| Full Sequence |
|---|
| Protein Sequence Length: 553 Download |
| MENSAIAAIL FLLYFFVFCP QLGVHSFATP SDVQDFSYLK FVRNATDLPL QEKYDYIVVG 60 GGTAGCPLAA TLSANYSVLL LERGDIPTAY PNVLSNAGIL ANFMQEDDGK TPAQRFTSED 120 GVAFVRGRVL GGSSMINVGL YSRADSEFLK KSGIKLDMNL VNNSYEWVEN TLVFRPNLSH 180 WQSVVKDALL EAGVRPDNGL TLDHIQGTKI TGTIFDDRGR RHGAVELLNK GHPKNLRVAI 240 HAAVERIIFS SKASGLSAKG IIYTDSNGRS HQALIRGKGE VILSAGAIGS PQLLLLSGVG 300 PKSYLSSLKI PVVHPQPYVG QFMRDNPRXY VTILPPSELE PSTAQIAGIT SDYYIETFSG 360 LPFSTMAFSL FPNPTIPMTI NSTFGHIVTK NPAPLSYGSL KLQSSYDVKV GPXVKFNYFA 420 XKADLSRCVS AVRKMGDLLK TXXLKPFKXX DLPGEXGFNL FGPPLPMNXS DVASIETFCR 480 DTVATXWHYH GGCLVGKVVD GDFRVRGIKA LRVVDGSVFK SLSPGTNPQA TLMMLGRHVG 540 LRMLEERSAC KGR 600 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| COG2303 | BetA | 2.0e-14 | 52 | 147 | 105 | + Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism] | ||
| COG2303 | BetA | 2.0e-31 | 218 | 549 | 361 | + Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism] | ||
| TIGR01810 | betA | 5.0e-34 | 55 | 536 | 554 | + choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli , Staphylococcus xylosus , and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified [Cellular processes, Adaptations to atypical conditions]. | ||
| TIGR03970 | Rv0697 | 7.0e-35 | 55 | 536 | 524 | + dehydrogenase, Rv0697 family. This model describes a set of dehydrogenases belonging to the glucose-methanol-choline oxidoreductase (GMC oxidoreductase) family. Members of the present family are restricted to Actinobacterial genome contexts containing also members of families TIGR03962 and TIGR03969 (the mycofactocin system), and are proposed to be uniform in function. | ||
| PLN02785 | PLN02785 | 2.0e-166 | 52 | 547 | 539 | + Protein HOTHEAD | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors |
| GO:0050660 | flavin adenine dinucleotide binding |
| GO:0055114 | oxidation-reduction process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | AAL11514.1 | 0 | 1 | 549 | 1 | 546 | AF412329_1 R-oxynitrile lyase isoenzyme 1 precursor [Prunus dulcis] |
| GenBank | ACY69987.1 | 0 | 21 | 549 | 16 | 538 | mandelonitrile lyase 1 [Eriobotrya japonica] |
| DDBJ | BAH23313.1 | 0 | 24 | 551 | 26 | 550 | (R)-hydroxynitrile lyase [Prunus mume] |
| DDBJ | BAH23314.1 | 0 | 24 | 551 | 26 | 550 | (R)-hydroxynitrile lyase [Prunus mume] |
| Swiss-Prot | P52707 | 0 | 1 | 551 | 1 | 549 | MDL3_PRUSE RecName: Full=(R)-mandelonitrile lyase 3; AltName: Full=Hydroxynitrile lyase 3; Short=(R)-oxynitrilase 3; Flags: Precursor |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3red_L | 0 | 27 | 550 | 1 | 521 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
| PDB | 3red_K | 0 | 27 | 550 | 1 | 521 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
| PDB | 3red_J | 0 | 27 | 550 | 1 | 521 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
| PDB | 3red_I | 0 | 27 | 550 | 1 | 521 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
| PDB | 3red_H | 0 | 27 | 550 | 1 | 521 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
