y
Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000142939 |
Family | GT47 |
Protein Properties | Length: 484 Molecular Weight: 56332.4 Isoelectric Point: 9.4822 |
Chromosome | Chromosome/Scaffold: 02193798 Start: 1875 End: 3937 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 156 | 437 | 0 |
EKMFKIYVYEEGELPIFHNGPCKNIYSMEGLFLSFMETDTKFRTREPENAHVYFLPFSVVMIVEYLFHPIIRDKAVLERTVVDYVRIISNRYPYWNRSLG ADHVMLSCHDWGPRATWYVKQLYFVAIRVLCNANTSEHFNPKKDASFPEINLETGEITGLIGGLHPSKRTILAFFAGRMHGRIRPFLFEHWKGKDRDLLV YEKLPEELSYHDMLKKSKYCICPSGHEVASPRIVEAIYADCVPVLISQHYVLPFSDVLNWDSFSVQVSVSEIPKLKEILMGI |
Full Sequence |
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Protein Sequence Length: 484 Download |
MPLIRKRKMK QVYRRYQNAI VFAMASFAIV YMVVSLVTNG SKGTSQFPWL GTGVDMISDS 60 TFRINYISSY KDATRMKALP DLGRGYIGDS VPQRDWQKGD ENLKKLEAGL AAARALIGEA 120 IKNLNHTTPL KDADYIPKGD IYRNAYAFHR SYLLMEKMFK IYVYEEGELP IFHNGPCKNI 180 YSMEGLFLSF METDTKFRTR EPENAHVYFL PFSVVMIVEY LFHPIIRDKA VLERTVVDYV 240 RIISNRYPYW NRSLGADHVM LSCHDWGPRA TWYVKQLYFV AIRVLCNANT SEHFNPKKDA 300 SFPEINLETG EITGLIGGLH PSKRTILAFF AGRMHGRIRP FLFEHWKGKD RDLLVYEKLP 360 EELSYHDMLK KSKYCICPSG HEVASPRIVE AIYADCVPVL ISQHYVLPFS DVLNWDSFSV 420 QVSVSEIPKL KEILMGIPEE QYRRMQERVK QVQRHFVVNN PPKRYDVFHM IIHSIWLRRL 480 NVQI 540 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 3.0e-58 | 155 | 437 | 301 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI28482.1 | 0 | 73 | 484 | 224 | 634 | unnamed protein product [Vitis vinifera] |
RefSeq | NP_187419.1 | 0 | 105 | 484 | 87 | 469 | exostosin family protein [Arabidopsis thaliana] |
RefSeq | XP_002264111.1 | 0 | 155 | 484 | 1 | 330 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002320537.1 | 0 | 94 | 483 | 2 | 392 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002524592.1 | 0 | 101 | 484 | 2 | 386 | catalytic, putative [Ricinus communis] |