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Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000153012 |
Family | GT47 |
Protein Properties | Length: 643 Molecular Weight: 73356.1 Isoelectric Point: 8.5368 |
Chromosome | Chromosome/Scaffold: 019523491 Start: 2606 End: 7015 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 370 | 637 | 0 |
DTLKVYVYREGERPILHKPVLTGIYASEGWFMKQMEADKKFVTKDPRKAHLYYLPFSSLMLEETLYVRDSHSYTNLVQYLKNYVETIAVKYPFWNRTGGA DHFLVACHDWAPTETKKYMARCIRALCNADVKQGFVFGKDVSLPETYVHTAKNPLRNIGGNRPSKRPILAFFAGQLHGYVRPILLQHWENKDPDMKIFGR LPKGKGNKNYAHHMQSSKYCICAKGYEVNSPRVVEAIFYECVPVIISDNFVPPFFEVLNWDSFAVFVW |
Full Sequence |
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Protein Sequence Length: 643 Download |
MKLETGLVDC KVCKGTEKNC LVAKKLWEND EMKGKRNKAW HTREDLNNQE QKINFELQKL 60 FLEREAAEIE NCSELHNKLI SSDYNLSVAT LPCFMXWSNR LRLSRFCPGI TGVVSQMGMD 120 LLSVCQVEPR RVMWIVGMIF ALVLVVQRLE HPYGNLLSSI LSAAKVPLTS LSTSQMVGNV 180 SLLNDLSFVE KKNTTDNAFL DSKTRNERDT TDEVVINSTA GFLTASPVSP MVNSSPKVGA 240 PTIVVDSNVT LVEKDGTASS EKTKTSEQLH NDLKQTQHNS SLIRAPEVNK EPEVPVLDVY 300 SMSDMKNLLL QSRSSDHSVI PKWSSTVDQE LQYAASQIEN VPIIKNDPTL YAPLYRNLSM 360 FKRSYELMED TLKVYVYREG ERPILHKPVL TGIYASEGWF MKQMEADKKF VTKDPRKAHL 420 YYLPFSSLML EETLYVRDSH SYTNLVQYLK NYVETIAVKY PFWNRTGGAD HFLVACHDWA 480 PTETKKYMAR CIRALCNADV KQGFVFGKDV SLPETYVHTA KNPLRNIGGN RPSKRPILAF 540 FAGQLHGYVR PILLQHWENK DPDMKIFGRL PKGKGNKNYA HHMQSSKYCI CAKGYEVNSP 600 RVVEAIFYEC VPVIISDNFV PPFFEVLNWD SFAVFVWRKI FRI 660 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 1.0e-67 | 368 | 636 | 289 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI20855.1 | 0 | 117 | 601 | 1 | 542 | unnamed protein product [Vitis vinifera] |
RefSeq | NP_197954.1 | 0 | 126 | 639 | 10 | 594 | exostosin family protein [Arabidopsis thaliana] |
RefSeq | XP_002281263.1 | 0.00000006 | 117 | 196 | 1 | 83 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002281263.1 | 0 | 178 | 639 | 138 | 608 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002309547.1 | 0 | 232 | 639 | 1 | 410 | predicted protein [Populus trichocarpa] |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
ES808098 | 306 | 337 | 642 | 0 |
HE642074 | 276 | 364 | 639 | 0 |
FE681588 | 284 | 308 | 591 | 0 |
GO247950 | 259 | 377 | 635 | 0 |
GO247950 | 37 | 340 | 376 | 0.0000002 |
Sequence Alignments (This image is cropped. Click for full image.) |
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