Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000161200 |
Family | GT47 |
Protein Properties | Length: 519 Molecular Weight: 58132.3 Isoelectric Point: 9.6118 |
Chromosome | Chromosome/Scaffold: 002032255 Start: 1146 End: 5561 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 187 | 467 | 0 |
EKVFKIYVYEEGEVPIFHDGPCRSIYSSEGRFIHEMEKGKMYRTKDPHKALVYFLPFSVVNMVQYIYMPETFDRSGMKRAVVDYINLISHKHPFWNRSLG ADHFMLSCHDWGPTTTSFVPDLFHNSIRVLCNANTSEGFNPLKDASFPEINLKTSEMPGIGGRPPSKRSTLAFFAGRLHGHIRYLLLNEWKGKDQDVQVY DQLPRRVSYENMLKSSKFCLCPSGYEVASPRVVEAIYAECVPVLISDGYVPPFSDVLNWKSFSVQIPVKNISDIKTXLTAI |
Full Sequence |
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Protein Sequence Length: 519 Download |
MRPSRHKPVS XLSSILVGLI LVVTLAVILL AISSAFSSSS SSEITSTVAA ASAATGDSLP 60 ALSSAQPPPP PQPPLLTTAA AAPAPAPSPA PQILAADVLQ ETIIQKVEGD ATNYTAKKND 120 DVANRTVFIS GSQLDKVEAS LGRARSSIRE AALVRNKTST HQDPDYVPRG PIYRNPNAFH 180 RSYLEMEKVF KIYVYEEGEV PIFHDGPCRS IYSSEGRFIH EMEKGKMYRT KDPHKALVYF 240 LPFSVVNMVQ YIYMPETFDR SGMKRAVVDY INLISHKHPF WNRSLGADHF MLSCHDWGPT 300 TTSFVPDLFH NSIRVLCNAN TSEGFNPLKD ASFPEINLKT SEMPGIGGRP PSKRSTLAFF 360 AGRLHGHIRY LLLNEWKGKD QDVQVYDQLP RRVSYENMLK SSKFCLCPSG YEVASPRVVE 420 AIYAECVPVL ISDGYVPPFS DVLNWKSFSV QIPVKNISDI KTXLTAISSR QYLRMQRRVK 480 QVQRHFLVNG PPKRYDVFHM IVHSIWLRRL NIRIQDVFT |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 2.0e-61 | 186 | 467 | 302 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | AAU04753.1 | 0 | 181 | 516 | 7 | 343 | EXO [Cucumis melo] |
EMBL | CBI28483.1 | 0 | 159 | 516 | 58 | 416 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002264076.1 | 0 | 186 | 516 | 1 | 332 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002320538.1 | 0 | 186 | 516 | 1 | 332 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002524591.1 | 0 | 112 | 517 | 97 | 505 | catalytic, putative [Ricinus communis] |