Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000162640 |
Family | GT47 |
Protein Properties | Length: 568 Molecular Weight: 64918.1 Isoelectric Point: 9.351 |
Chromosome | Chromosome/Scaffold: 002117463 Start: 7106 End: 10007 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 111 | 453 | 0 |
IRVYVYDMPSKFTYDLLWLFRNSYKETFNLTSNGSPVHRLIEQHSIDYWLWADLIAPESERLLKSVVRVHRQEEADLFYIPFFTTISFFLLEKQQCKALY REVVKWVTDQPAWNRSQGHDHILPVHHPWSFKSVRRLMKDAIWLLPDMDSTGNWSIFHSISFLSPKFTKIITQLKLVLTVVYSTIRYKPGQVYLEKDLIL PYVANVDFCDARCISETRTKRTTLLFFRGRLKRNAGGKIRSQLVAELNGADGVAIEEGTAGETGKAAAQNGMRKSVFCLSPAGDTPSSARLFDAIVSGCI PVIVSDELELPFEGILDYRKIALFISSSDAVRPGWLVTYLRNI |
Full Sequence |
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Protein Sequence Length: 568 Download |
MARSKYPVLL LLLPLLALSL IFLLFSFHGP SPSDPSAILH PYQPIYKPET SFVASLERFL 60 LAHKSGPPKP RDDTVLTTPT QSQLTHLDDL VFQSDSHRLY ADPYYPLSLP IRVYVYDMPS 120 KFTYDLLWLF RNSYKETFNL TSNGSPVHRL IEQHSIDYWL WADLIAPESE RLLKSVVRVH 180 RQEEADLFYI PFFTTISFFL LEKQQCKALY REVVKWVTDQ PAWNRSQGHD HILPVHHPWS 240 FKSVRRLMKD AIWLLPDMDS TGNWSIFHSI SFLSPKFTKI ITQLKLVLTV VYSTIRYKPG 300 QVYLEKDLIL PYVANVDFCD ARCISETRTK RTTLLFFRGR LKRNAGGKIR SQLVAELNGA 360 DGVAIEEGTA GETGKAAAQN GMRKSVFCLS PAGDTPSSAR LFDAIVSGCI PVIVSDELEL 420 PFEGILDYRK IALFISSSDA VRPGWLVTYL RNISHAQIEE LRQNLAKTCF LGAMLYCFFI 480 LSKGWSRHKS SWGLIYAICH SQYSRHFLYS SPAQPLGPED LVWRMMAGKL VNIKLHTRRS 540 QRVVKESRSI CTCECKRANS TTTGHLQL |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 5.0e-52 | 110 | 453 | 352 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | EAY76230.1 | 0 | 33 | 552 | 45 | 488 | hypothetical protein OsI_04166 [Oryza sativa Indica Group] |
RefSeq | NP_197191.1 | 0 | 2 | 557 | 13 | 497 | exostosin family protein [Arabidopsis thaliana] |
RefSeq | XP_002285599.1 | 0 | 48 | 561 | 62 | 511 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002325382.1 | 0 | 47 | 562 | 56 | 502 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002520033.1 | 0 | 28 | 561 | 44 | 502 | catalytic, putative [Ricinus communis] |