Basic Information | |
---|---|
Species | Malus domestica |
Cazyme ID | MDP0000163412 |
Family | CBM57 |
Protein Properties | Length: 942 Molecular Weight: 105388 Isoelectric Point: 7.309 |
Chromosome | Chromosome/Scaffold: 001085298 Start: 3501 End: 9973 |
Description | receptor-like kinase in flowers 1 |
View CDS |
External Links |
---|
NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
---|---|---|---|
Family | Start | End | Evalue |
CBM57 | 373 | 544 | 9.7e-26 |
MHINCGGSDIIVKDENNANVLFEGDGRVEGGSAKYFRNEKSMWGFSSTGDFMDGFELQNTRYSVSLXSSNLSELYTTARISPLSLTYFHYCLENGIYTIT LHFAEIKFTNDKGYTSLGRRIFDIYVQEKLVWKDFNIEHEAGMAQKRLVKQVDNVNVTSNVLEIRFYWAGKG |
Full Sequence |
---|
Protein Sequence Length: 942 Download |
MRQLAGNLLL FVCFIIIALS CFTLRGLAQL PKLPQQEVDA LQEIATTMGA NYWTFNTDAC 60 RIETVGLTKK QPKGSQANTD CDCNFENSTV CHVATLTLKG FSLPGLLPPQ LVKLPYLRKI 120 DFAYNYLNGT IPREWASTKL TYMNLEGNQF SGIVPTELGN LVNLQTLMLS SNQLTGYLPE 180 TFSGLRILND FRINDNNFSG TLPDWVQNWK KLTRLEMHSS GLEGLIPSNI SLLNNLEELR 240 ISDTNGPYQE FPLLRNLTSL VRLVLRNCNI SGEIPAYIWS MKNLEMLDVS FNKLAGQLPS 300 TIGAERLKFV FLTGNLLSGN VPRSILRDGS IVDLSYNNFT FQGPEKPDCQ KNLSEHILFS 360 TDYFLDYGDS NCMHINCGGS DIIVKDENNA NVLFEGDGRV EGGSAKYFRN EKSMWGFSST 420 GDFMDGFELQ NTRYSVSLXS SNLSELYTTA RISPLSLTYF HYCLENGIYT ITLHFAEIKF 480 TNDKGYTSLG RRIFDIYVQE KLVWKDFNIE HEAGMAQKRL VKQVDNVNVT SNVLEIRFYW 540 AGKGTTRIPE RGHYGPLISA VSVVSNFKPC TNSGTVRTIY IIAGVVGGIC LTLFIVAILW 600 WKRCLRGKXG RQKDLLGRDM QMRTFTFKQI KAATNDFDSA KKIGEGGFGP VYKGHLXDGS 660 LIAVKQLSSN SKQGNREFLN EMGMITCLQH PNLVTLHGCC IERDQLLLVY EYMENNSLAN 720 ALFGPENRIN LDWPTRVKIC TGIARGLAFL HEESRLKIVH RDIKATNVLL DGDLNPKISD 780 FGLAKLYDEE KTHVSTKVAG TMSVVSKFSS THFYIYTGYM APEYALLGHL TYKADVYSFG 840 VVALEIVSGK KNSYVPSNAC VSLLDWVAYQ LQQGGNLKEL IDESLVSEIN GKEAEVMVKV 900 GLLCTNVSPS LRPTMSEVVS MLEGQTTVPD TKPEARYHAL KI |
Functional Domains Download unfiltered results here | ||||||||
---|---|---|---|---|---|---|---|---|
Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
smart00221 | STYKc | 1.0e-48 | 641 | 922 | 288 | + Protein kinase; unclassified specificity. Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase. | ||
pfam07714 | Pkinase_Tyr | 1.0e-49 | 641 | 922 | 291 | + Protein tyrosine kinase. | ||
smart00219 | TyrKc | 8.0e-51 | 641 | 922 | 288 | + Tyrosine kinase, catalytic domain. Phosphotransferases. Tyrosine-specific kinase subfamily. | ||
cd00192 | PTKc | 2.0e-52 | 641 | 923 | 297 | + Catalytic domain of Protein Tyrosine Kinases. Protein Tyrosine Kinase (PTK) family, catalytic domain. This PTKc family is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. They can be classified into receptor and non-receptor tyr kinases. PTKs play important roles in many cellular processes including, lymphocyte activation, epithelium growth and maintenance, metabolism control, organogenesis regulation, survival, proliferation, differentiation, migration, adhesion, motility, and morphogenesis. Receptor tyr kinases (RTKs) are integral membrane proteins which contain an extracellular ligand-binding region, a transmembrane segment, and an intracellular tyr kinase domain. RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain, leading to intracellular signaling. Some RTKs are orphan receptors with no known ligands. Non-receptor (or cytoplasmic) tyr kinases are distributed in different intracellular compartments and are usually multi-domain proteins containing a catalytic tyr kinase domain as well as various regulatory domains such as SH3 and SH2. PTKs are usually autoinhibited and require a mechanism for activation. In many PTKs, the phosphorylation of tyr residues in the activation loop is essential for optimal activity. Aberrant expression of PTKs is associated with many development abnormalities and cancers. | ||
pfam11721 | Malectin | 2.0e-54 | 372 | 561 | 191 | + Di-glucose binding within endoplasmic reticulum. Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognises and binds Glc2-N-glycan. It carries a signal peptide from residues 1-26, a C-terminal transmembrane helix from residues 255-274, and a highly conserved central part of approximately 190 residues followed by an acidic, glutamate-rich region. Carbohydrate-binding is mediated by the four aromatic residues, Y67, Y89, Y116, and F117 and the aspartate at D186. NMR-based ligand-screening studies has shown binding of the protein to maltose and related oligosaccharides, on the basis of which the protein has been designated "malectin", and its endogenous ligand is found to be Glc2-high-mannose N-glycan. |
Gene Ontology | |
---|---|
GO Term | Description |
GO:0004672 | protein kinase activity |
GO:0005515 | protein binding |
GO:0005524 | ATP binding |
GO:0006468 | protein phosphorylation |
Annotations - NR Download unfiltered results here | |||||||
---|---|---|---|---|---|---|---|
Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
RefSeq | NP_174268.7 | 0 | 7 | 941 | 20 | 978 | RKF1 (RECEPTOR-LIKE KINASE IN FLOWERS 1); ATP binding / kinase/ protein serine/threonine kinase/ receptor signaling protein serine/threonine kinase [Arabidopsis thaliana] |
RefSeq | XP_002264679.1 | 0 | 37 | 938 | 5 | 953 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002264878.1 | 0 | 33 | 935 | 110 | 1009 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002305711.1 | 0 | 38 | 941 | 1 | 898 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002522277.1 | 0 | 48 | 934 | 1 | 859 | ATP binding protein, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
---|---|---|---|---|---|---|---|
Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3ulz_A | 0 | 621 | 924 | 16 | 308 | A Chain A, Raphanus Sativus Anionic Peroxidase. |
PDB | 3uim_A | 0 | 621 | 924 | 16 | 308 | A Chain A, Structural Basis For The Impact Of Phosphorylation On Plant Receptor- Like Kinase Bak1 Activation |
PDB | 3tl8_H | 0 | 621 | 924 | 24 | 316 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
PDB | 3tl8_G | 0 | 621 | 924 | 24 | 316 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
PDB | 3tl8_D | 0 | 621 | 924 | 24 | 316 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |