Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000174532 |
Family | GT47 |
Protein Properties | Length: 607 Molecular Weight: 69410.9 Isoelectric Point: 10.0859 |
Chromosome | Chromosome/Scaffold: 004632398 Start: 1718 End: 5965 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 261 | 559 | 0 |
EKKFKVYVYSEGDPPMTHDGPCKDIYSIEGRFIHEMENGAAGRRFKTENPQRAHVYFMPFSVTWMVKYLYKPLTYDLTPLRNFVSDYVRMVSVRHPFWNR TLGADHFMLACHDWRLNENFPTKYSQAPRASEGNPLLFNTSIRVLCNANTSEGFNPQKDVSLPEIHLYGGTVSSKLISPPPPNTLRPYLAFFAGGLHGPI RPILLAHWKNRDKDLQIHEYLPKGLDYDSMVLKSKFCLCPSGYEVASPRIVEAIYAECVPVILSEHYALPFSDVLRWEAFSVKVEVSEISRLKEVLMGV |
Full Sequence |
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Protein Sequence Length: 607 Download |
MGSFHAKYSS ASVLLCFCIS SIITVVVICG HHFDSPVIIS DSKQDRYSPV WIPVVQLRSK 60 LKGAYHRLAI SDDPSSTIQR FHSNDFVNQT SLRHKIPKRK ASGXQKLEQG LARARASIRR 120 AASSPNSSST PNDDVLFPGG SVVYRNPGAF YQHRLGSYRV RHRGVECALI CVLHRHILTP 180 PPYTRLLLKK RGVMNRTEIX LGSVFPTNKG LTLVNPLFVL RSRNVLTKVL ILYLWGTPAH 240 LVFSEPRKIS PGRGESYTEM EKKFKVYVYS EGDPPMTHDG PCKDIYSIEG RFIHEMENGA 300 AGRRFKTENP QRAHVYFMPF SVTWMVKYLY KPLTYDLTPL RNFVSDYVRM VSVRHPFWNR 360 TLGADHFMLA CHDWRLNENF PTKYSQAPRA SEGNPLLFNT SIRVLCNANT SEGFNPQKDV 420 SLPEIHLYGG TVSSKLISPP PPNTLRPYLA FFAGGLHGPI RPILLAHWKN RDKDLQIHEY 480 LPKGLDYDSM VLKSKFCLCP SGYEVASPRI VEAIYAECVP VILSEHYALP FSDVLRWEAF 540 SVKVEVSEIS RLKEVLMGVP EEKYRRLVEN LRVVRKHFEL NQPAKRFDVF HMILHSIWLR 600 RINLRIA |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 3.0e-54 | 260 | 559 | 318 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI21064.1 | 0.000005 | 52 | 152 | 45 | 140 | unnamed protein product [Vitis vinifera] |
EMBL | CBI21064.1 | 0 | 255 | 607 | 140 | 478 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002324871.1 | 0 | 260 | 607 | 1 | 334 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002515489.1 | 0.0000000002 | 7 | 152 | 7 | 143 | catalytic, putative [Ricinus communis] |
RefSeq | XP_002515489.1 | 0 | 255 | 607 | 143 | 481 | catalytic, putative [Ricinus communis] |