y
Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000175549 |
Family | GT47 |
Protein Properties | Length: 460 Molecular Weight: 51637 Isoelectric Point: 8.2949 |
Chromosome | Chromosome/Scaffold: 006167203 Start: 2985 End: 5287 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 84 | 383 | 0 |
RKYSAEYWILGDLMTPPEHRTGSFASRVFDADEADVVFVPFFATLSAELQLATAKGVFRKKAGNEDYERQRQVVDFVKNTEAWKRSGGRDHVFVLTDLNV VLKLEAFLADPVAMWHVRAEIAPAVLLVVDFGGWYTLESRSSNGNSSDVIQHTQVSLLKDVIVPYTHLLPRLQLTENKKRQTLLYFKGAKHRHRGGLVRE TLWDLLVNEPDVIMEEGFPNATGREQSIKGMRTSEFCLHPAGDTPTSCRLFDAMQSLCIPVIVSDNIELPFEGMVDYSEFSVFVAVDDALKPNWIVSHLR |
Full Sequence |
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Protein Sequence Length: 460 Download |
MAVKGTATTT PSSSVCSVPT LFFAFTLLCA LSLSLFFLSN PSPSSSPSPS SSSFISLNAP 60 LSPXKFPQSL PSRPPQIPQL WPPRKYSAEY WILGDLMTPP EHRTGSFASR VFDADEADVV 120 FVPFFATLSA ELQLATAKGV FRKKAGNEDY ERQRQVVDFV KNTEAWKRSG GRDHVFVLTD 180 LNVVLKLEAF LADPVAMWHV RAEIAPAVLL VVDFGGWYTL ESRSSNGNSS DVIQHTQVSL 240 LKDVIVPYTH LLPRLQLTEN KKRQTLLYFK GAKHRHRGGL VRETLWDLLV NEPDVIMEEG 300 FPNATGREQS IKGMRTSEFC LHPAGDTPTS CRLFDAMQSL CIPVIVSDNI ELPFEGMVDY 360 SEFSVFVAVD DALKPNWIVS HLRTFTREQR DRFRRTMAQF QPMFEYDNGH PGGIGPIPPD 420 GAVNHMWKMV HQKLPMIKES IVRERRKPPG VSVPRRCHCT 480 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 3.0e-49 | 148 | 385 | 247 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
RefSeq | NP_564443.1 | 0 | 71 | 459 | 93 | 476 | exostosin family protein [Arabidopsis thaliana] |
RefSeq | XP_002270238.1 | 0 | 1 | 460 | 1 | 440 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002325567.1 | 0 | 16 | 460 | 13 | 476 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002327326.1 | 0 | 31 | 460 | 1 | 449 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002533317.1 | 0 | 84 | 460 | 115 | 478 | catalytic, putative [Ricinus communis] |