Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000188276 |
Family | GT47 |
Protein Properties | Length: 1067 Molecular Weight: 121650 Isoelectric Point: 8.3148 |
Chromosome | Chromosome/Scaffold: 008847375 Start: 5055 End: 13702 |
Description | O-fucosyltransferase family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 123 | 447 | 0 |
KRSFKIYVYPHRQDDSFANALLPVDSEPXGNYASESYFKKVLMKSHFITNDPTKADLFFLPFSIARLRHDPRIGVGGIQDFIRDYIFNVSHKYEYWNRTG GADHFYVACHSIGRSAMEKANEVKFNAIQVVCSSSYFLPGYIPHKDACLPQIWPRNEKPPDLRSSNSITFXXCHIKWIXSYXKEMPAFWVEKMGILTXLD VRRXIVCGREWDFGTKLAFFAGGINSPVREKLLQVWRNDSEIFAHFGRLTTPYADELLGSRFCLHVKGFEVNTARIADSLYYGCVPVIIANYYDLPFADV INWSSFSVIVATLDIPLLKKILKEI |
Full Sequence |
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Protein Sequence Length: 1067 Download |
MADSSSVVLY YLSQPRSLRH FYFIPTTLAL ATSLLILFYI SSTSNLFAHH HHHAHSIPQL 60 LLNISSSYTP FRVEAHLKAD GAQVIQGQRS PEQPQLGSNG NYVNNKAVFH DRHIFLEDYK 120 EMKRSFKIYV YPHRQDDSFA NALLPVDSEP XGNYASESYF KKVLMKSHFI TNDPTKADLF 180 FLPFSIARLR HDPRIGVGGI QDFIRDYIFN VSHKYEYWNR TGGADHFYVA CHSIGRSAME 240 KANEVKFNAI QVVCSSSYFL PGYIPHKDAC LPQIWPRNEK PPDLRSSNSI TFXXCHIKWI 300 XSYXKEMPAF WVEKMGILTX LDVRRXIVCG REWDFGTKLA FFAGGINSPV REKLLQVWRN 360 DSEIFAHFGR LTTPYADELL GSRFCLHVKG FEVNTARIAD SLYYGCVPVI IANYYDLPFA 420 DVINWSSFSV IVATLDIPLL KKILKEISSD EYLRLQSNVL KSVPNKKLWG PVKPLQSLQP 480 YANPRSNYPV PNDQSNGFIY AKIFGGFEKI RSTICDLVTI SRLLNATLVI PDIQESTRSK 540 GISSRFKSFT YLYDEVHFIA SLKNDIVIVK SLPDNLKAAR KRNEFPSFRP KKSASPNFYI 600 KEVLPKLRKT KVIGLVIADG GCLQSILPPN MAEFQRLRCR VAFHALQFRP EIQVLGHKMV 660 ERLRAWGQPF LAYHPGLVRE TLAYHGCAEL FQDVHTELIQ YRRKQMIKKG IVHEELSIDS 720 HLRRENGSCP LMPEEVGILL RSMGYPPKTI IYLAGSETFG GQRVLVPLRA MFPNLVDRTS 780 LCSNKELSDI LGPETPLPQN PFQRLPAKSK EQLKEKWKKA GPRPRPLPPP PGRPIYQHEK 840 EGWYGWITES DTEPDLSALD LRMQAHRLIW DXLDYIVSVE ADTFFPGFNN DGSGWPDFSS 900 LVMGHRVYEV ASSRTYRPDR KVAAELFNMT RDNVYHPKHN WTVSVQEHLK KSLSEEGLIR 960 QSVLSKPALF ISHPLPECSC RISSANAPVH VKGNDGRTIY GGEEECPKWM KHGDEVPLDS 1020 AGEEGKVEDN ELSEYGSTLD EQPESNDSDR TNATLVSEQD EEMXPND |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
cd11299 | O-FucT_plant | 2.0e-6 | 866 | 909 | 44 | + GDP-fucose protein O-fucosyltransferase, plant specific subfamily. Some members of this plant-specific family of O-fucosyltransferases have been annotated as auxin-independent growth promotors. The function of the protein seems unclear. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
pfam03016 | Exostosin | 1.0e-63 | 122 | 447 | 339 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
pfam10250 | O-FucT | 8.0e-78 | 498 | 796 | 302 | + GDP-fucose protein O-fucosyltransferase. This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. | ||
cd11299 | O-FucT_plant | 3.0e-92 | 498 | 788 | 291 | + GDP-fucose protein O-fucosyltransferase, plant specific subfamily. Some members of this plant-specific family of O-fucosyltransferases have been annotated as auxin-independent growth promotors. The function of the protein seems unclear. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | AAF00637.1 | 0 | 465 | 1067 | 41 | 638 | AC009540_14 putative auxin-independent growth promoter protein [Arabidopsis thaliana] |
DDBJ | BAF00006.1 | 0 | 465 | 1067 | 59 | 656 | putative auxin-independent growth promoter protein [Arabidopsis thaliana] |
EMBL | CBI25298.1 | 0 | 465 | 1067 | 58 | 663 | unnamed protein product [Vitis vinifera] |
RefSeq | NP_187031.2 | 0 | 465 | 1067 | 59 | 656 | EDA30 (embryo sac development arrest 30) [Arabidopsis thaliana] |
RefSeq | XP_002325426.1 | 0 | 461 | 1067 | 57 | 652 | predicted protein [Populus trichocarpa] |