y
Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000189628 |
Family | GH79 |
Protein Properties | Length: 570 Molecular Weight: 62961.6 Isoelectric Point: 8.6335 |
Chromosome | Chromosome/Scaffold: 009785178 Start: 39966 End: 42596 |
Description | glucuronidase 2 |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 69 | 562 | 0 |
DNNFVCATIDWWNHEKCDYGHCPWGNASALNLNLSHPLLAKSIQAFDQLRIRIGGSLEDQLLYDVGNLKYPCHPFRKMKGGLFGFSRGCLTMSRWDELNQ FFSKTRSIITFSLNALLGRHHKGGGAWVGDWDSSNAYDFIKYTVSKRYQIDSWEFGNELSGSGVEASVGAGQYGRDLIKLKSIINHLYNESVPKPALMAP GGFFDQSWFTRLLQVSGSGTVDIISQHLYNLGAGVDPTLVKKILDPHYLDRAYGSFHDLEQTVKKNGPWASIWVGESGGAYNSGGRNVSDTYVNSFWYLD QLGMSAKYNTRVYCRQSLVGGNYGLLNRTSFVPNPDYYSALLWHRLMGQGVLSANNNGSADLRTYAHCTRGRAGITLLLINLSNETNFIVNIANVLDTDL GAQAGNVSKESYFKRGLKRTVSWVGRKALDEAIYREEYHLTPKDGDVKSKTMVLNGAPLEITKDGNIPELEPTRVDMKAPLRIAPLSIKFVVLP |
Full Sequence |
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Protein Sequence Length: 570 Download |
MSSGGATRSL LLKAGGEIAA TEFPMAFRLS LVLFLVSLPA ILAQDFGKTN NVENVKVVVN 60 GSLAVAQVDN NFVCATIDWW NHEKCDYGHC PWGNASALNL NLSHPLLAKS IQAFDQLRIR 120 IGGSLEDQLL YDVGNLKYPC HPFRKMKGGL FGFSRGCLTM SRWDELNQFF SKTRSIITFS 180 LNALLGRHHK GGGAWVGDWD SSNAYDFIKY TVSKRYQIDS WEFGNELSGS GVEASVGAGQ 240 YGRDLIKLKS IINHLYNESV PKPALMAPGG FFDQSWFTRL LQVSGSGTVD IISQHLYNLG 300 AGVDPTLVKK ILDPHYLDRA YGSFHDLEQT VKKNGPWASI WVGESGGAYN SGGRNVSDTY 360 VNSFWYLDQL GMSAKYNTRV YCRQSLVGGN YGLLNRTSFV PNPDYYSALL WHRLMGQGVL 420 SANNNGSADL RTYAHCTRGR AGITLLLINL SNETNFIVNI ANVLDTDLGA QAGNVSKESY 480 FKRGLKRTVS WVGRKALDEA IYREEYHLTP KDGDVKSKTM VLNGAPLEIT KDGNIPELEP 540 TRVDMKAPLR IAPLSIKFVV LPFFDAQACL 600 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 5.0e-170 | 61 | 371 | 311 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI15157.1 | 0 | 37 | 569 | 13 | 512 | unnamed protein product [Vitis vinifera] |
RefSeq | NP_196400.2 | 0 | 25 | 569 | 1 | 542 | AtGUS2 (Arabidopsis thaliana glucuronidase 2); beta-glucuronidase |
RefSeq | XP_002284470.1 | 0 | 37 | 569 | 13 | 538 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002321464.1 | 0 | 25 | 569 | 1 | 540 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002514696.1 | 0 | 39 | 569 | 15 | 538 | Heparanase-2, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.000003 | 154 | 463 | 112 | 411 | A Chain A, X-Ray Crystal Structure Of Leacx1, An Acyl-Coa Oxidase From Lycopersicon Esculentum (Tomato) |
PDB | 3vnz_A | 0.000003 | 154 | 463 | 112 | 411 | A Chain A, X-Ray Crystal Structure Of Leacx1, An Acyl-Coa Oxidase From Lycopersicon Esculentum (Tomato) |
PDB | 3vny_A | 0.000003 | 154 | 463 | 112 | 411 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
HO797031 | 370 | 202 | 569 | 0 |
CN905942 | 224 | 86 | 309 | 0 |
EC920863 | 287 | 98 | 384 | 0 |
CO121889 | 291 | 240 | 530 | 0 |
CK266509 | 313 | 113 | 425 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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