Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000199026 |
Family | GT47 |
Protein Properties | Length: 603 Molecular Weight: 68549.4 Isoelectric Point: 9.3031 |
Chromosome | Chromosome/Scaffold: 01198537 Start: 2144 End: 6016 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 179 | 491 | 0 |
PVKVYLYDLPKRFTYGVIKHHSLARGGRPDDDVLKLKYPGHQHMGEWYLFQDLLKPDSERVGSPVENILDPEEADLFYVPFFSSLSLIVNQARPASGSEK PLYSDEENQVALIEWLEAQEYWKRNNGRDHVIMASDPNALYKVIDRVKNCVLLVCDFGRLKEDQGSLVKDVIVPYSHRINTYTGDISVENRNTLLFFMGN RFRKEGGKIRDLLFQLLENEEDVIVKHGTQSRVSRRAATQGMHMSKFCLNPAGDTPSACRLFDSIVSMCVPVIVSDSIELPFEDVIDYRRIAIFVESNAA LKPGFLVSMLRGI |
Full Sequence |
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Protein Sequence Length: 603 Download |
MERAIRLLRL AIANPAKSKV EKFENQAEEE DDDDGIKWTH TFSILKGYLK RKRTCLPVST 60 WRTLACAPTG IMNSELRSSK AKRTAKPSSP SSTNSPHARR RRQILTQFLS MARKSSLLKQ 120 SLATIVGVLV LYAFLSTFLT PAATSKLENA FPSFSSAASN SISNEFVSRE NQLNFPGKPV 180 KVYLYDLPKR FTYGVIKHHS LARGGRPDDD VLKLKYPGHQ HMGEWYLFQD LLKPDSERVG 240 SPVENILDPE EADLFYVPFF SSLSLIVNQA RPASGSEKPL YSDEENQVAL IEWLEAQEYW 300 KRNNGRDHVI MASDPNALYK VIDRVKNCVL LVCDFGRLKE DQGSLVKDVI VPYSHRINTY 360 TGDISVENRN TLLFFMGNRF RKEGGKIRDL LFQLLENEED VIVKHGTQSR VSRRAATQGM 420 HMSKFCLNPA GDTPSACRLF DSIVSMCVPV IVSDSIELPF EDVIDYRRIA IFVESNAALK 480 PGFLVSMLRG IPTERILEYQ TELNEFLNWD SCTDFSFLES HGKAEGAKNN RVFTARKVSY 540 RVKHYFQYGE PNGTVNEIWR QIAQKLPFIK LTINRNRRLV KRDSNVRDCS CLCSNQTGII 600 TSL |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 9.0e-75 | 176 | 491 | 327 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CAN68074.1 | 0 | 111 | 603 | 1 | 461 | hypothetical protein [Vitis vinifera] |
RefSeq | NP_850241.1 | 0 | 111 | 603 | 1 | 447 | ARAD1 (ARABINAN DEFICIENT 1); catalytic/ transferase, transferring glycosyl groups [Arabidopsis thaliana] |
RefSeq | XP_002318294.1 | 0 | 184 | 603 | 1 | 382 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002322391.1 | 0 | 111 | 603 | 1 | 457 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002523645.1 | 0 | 111 | 603 | 1 | 452 | catalytic, putative [Ricinus communis] |