Basic Information | |
---|---|
Species | Malus domestica |
Cazyme ID | MDP0000200985 |
Family | GT47 |
Protein Properties | Length: 347 Molecular Weight: 38713.5 Isoelectric Point: 6.6509 |
Chromosome | Chromosome/Scaffold: 013778207 Start: 51 End: 2110 |
Description | Exostosin family protein |
View CDS |
External Links |
---|
NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
---|---|---|---|
Family | Start | End | Evalue |
GT47 | 206 | 344 | 1.8e-24 |
PVKVYLYDLPKRFTYGVIEHHSLARGGRPDDDVSKLKYPGHQHMGEWYLFQDLLKPESERVGSPVERALDPEEADLFYVPFFSSLSLIVNPARPASGSEK PLYSDEENQVALIEWLESQEYWKRNSGRDHVIMASDPNA |
Full Sequence |
---|
Protein Sequence Length: 347 Download |
MQQVNGGVKH LVMQAALMES FRNTGCLSNE EWRMEHGVPE SVLEDKERSH KVGLGRLAVL 60 QDEMCEEELK SLAACTEKPT CPPVHNLAHV SRAHRXPKTT GMMSSELQSS KANKPSAPSS 120 TSLDXLHRKT LTQFLSMARK SSLLKQSLAT IVGVLVLYAF LNTFLTPAAT SKLENAFPSF 180 SSVASNSISS DVFATLENQL NLPGKPVKVY LYDLPKRFTY GVIEHHSLAR GGRPDDDVSK 240 LKYPGHQHMG EWYLFQDLLK PESERVGSPV ERALDPEEAD LFYVPFFSSL SLIVNPARPA 300 SGSEKPLYSD EENQVALIEW LESQEYWKRN SGRDHVIMAS DPNALYK |
Functional Domains Download unfiltered results here | ||||||||
---|---|---|---|---|---|---|---|---|
Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 3.0e-22 | 203 | 342 | 140 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
---|---|
GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
---|---|---|---|---|---|---|---|
Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | ABN04854.1 | 0 | 97 | 347 | 2 | 238 | Exostosin-like [Medicago truncatula] |
EMBL | CAN68074.1 | 0 | 137 | 346 | 1 | 213 | hypothetical protein [Vitis vinifera] |
RefSeq | XP_002276440.1 | 0 | 110 | 346 | 7 | 246 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002322391.1 | 0 | 137 | 347 | 1 | 210 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002523645.1 | 0 | 137 | 347 | 1 | 205 | catalytic, putative [Ricinus communis] |