| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000203950 |
| Family | GH89 |
| Protein Properties | Length: 420 Molecular Weight: 47476.2 Isoelectric Point: 6.6212 |
| Chromosome | Chromosome/Scaffold: 012292276 Start: 10274 End: 18136 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH89 | 225 | 416 | 0 |
| DFNISKEDLNDFFGGSAFLAWARMGNLHAWGGPLSQNWLDQQLVLQKQILSRMLELGMTPVLPSFSGNVPVTLKKVYPSANITRLGEWNTVDGDPRWCCT YLLDPSDPLFVEIGMAFVRRQVEEYGDVTDIYNCDTFNENTPPTNDTAYISSLGAAVYKAMSKGDKDAVWLMQGWLFYSDSAFWKPPQMKKV | |||
| Full Sequence |
|---|
| Protein Sequence Length: 420 Download |
| MATDMAQLGT FDFQIAVSAK AEAVTALLRR LDSKRSSASV QEAAAKAVLE RLLPTHVHSF 60 DFKIVSQDAC GGHSCFMLNN YNLSSGHGPE IQVKGTTAVE IASGLHWYLK YWCGAHVSWD 120 KTGGAQLASI PSPGSLPRVR DEGLRIQRPV PWNYYQNVVT SSYSFVWWDW ERWQKEIDWM 180 ALQGINLPLA FTGQESIWQK VFMIYILLTF LPYQKSRQCT YAKYDFNISK EDLNDFFGGS 240 AFLAWARMGN LHAWGGPLSQ NWLDQQLVLQ KQILSRMLEL GMTPVLPSFS GNVPVTLKKV 300 YPSANITRLG EWNTVDGDPR WCCTYLLDPS DPLFVEIGMA FVRRQVEEYG DVTDIYNCDT 360 FNENTPPTND TAYISSLGAA VYKAMSKGDK DAVWLMQGWL FYSDSAFWKP PQMKKVALLI 420 480 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 2.0e-25 | 41 | 139 | 99 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam05089 | NAGLU | 2.0e-123 | 154 | 419 | 266 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI24942.1 | 0 | 15 | 416 | 82 | 462 | unnamed protein product [Vitis vinifera] |
| GenBank | EEE59081.1 | 0 | 36 | 416 | 51 | 411 | hypothetical protein OsJ_10898 [Oryza sativa Japonica Group] |
| RefSeq | NP_196873.1 | 0 | 16 | 416 | 20 | 399 | alpha-N-acetylglucosaminidase family / NAGLU family [Arabidopsis thaliana] |
| RefSeq | XP_002273084.1 | 0 | 15 | 416 | 17 | 397 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002314048.1 | 0 | 19 | 416 | 24 | 401 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 4.99983e-42 | 60 | 399 | 190 | 492 | A Chain A, Crystal Structure Of Udp-Galactose 4-Epimerase |
| PDB | 2vcb_A | 4.99983e-42 | 60 | 399 | 190 | 492 | A Chain A, Crystal Structure Of Udp-Galactose 4-Epimerase |
| PDB | 2vca_A | 4.99983e-42 | 60 | 399 | 190 | 492 | A Chain A, Crystal Structure Of Udp-Galactose 4-Epimerase |
| PDB | 2vc9_A | 4.99983e-42 | 60 | 399 | 190 | 492 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 1.99993e-41 | 60 | 399 | 213 | 515 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| Hydropathy |
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| EST Download unfiltered results here | ||||
|---|---|---|---|---|
| Hit | Length | Start | End | EValue |
| CB644785 | 284 | 102 | 385 | 0 |
| CB632336 | 292 | 84 | 375 | 0 |
| CB648955 | 281 | 102 | 382 | 0 |
| CB660486 | 269 | 102 | 370 | 0 |
| CB620902 | 297 | 41 | 336 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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