Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000204575 |
Family | GT47 |
Protein Properties | Length: 474 Molecular Weight: 54038.4 Isoelectric Point: 8.2566 |
Chromosome | Chromosome/Scaffold: 014216249 Start: 12770 End: 14194 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 48 | 411 | 0 |
CTGRWIHIRRLPPAFNLDLLSNCSGYGLFDDFCPYLANHGLGQKTHNLSHSWYRTDPLMLELIFHRRMLEYPCLTSDPQSADAVYLPYYAGIDALRYLYG PDYNSSSEQGLNLFEFLTRDDPDLWNRNMGHDHFLVLARPALDFSQPLGNDPRVWGTSLLELPQFFNVTALTLEARAWPWQEHAVPYPSSFHPPNLSLLE AWVQRARRSRRTTLMMFAGGGGVGNNPNIRKSIRNECENNTIENNVTSNNNNLGMFGSGFAEYTRLCDFVDCSNGICEHDPIRFMRPMLQASFCMQPPGD TPTRRSTFDSIVAGCIPVFFESLSAKVQYGWHLPEDQYGDFSVFIPKEDVVYKETRVLDVLRSI |
Full Sequence |
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Protein Sequence Length: 474 Download |
MASSKSTLLI TTSFLLFFFS STTTTTIRLS SAQVPRNNLD PSQSDSDCTG RWIHIRRLPP 60 AFNLDLLSNC SGYGLFDDFC PYLANHGLGQ KTHNLSHSWY RTDPLMLELI FHRRMLEYPC 120 LTSDPQSADA VYLPYYAGID ALRYLYGPDY NSSSEQGLNL FEFLTRDDPD LWNRNMGHDH 180 FLVLARPALD FSQPLGNDPR VWGTSLLELP QFFNVTALTL EARAWPWQEH AVPYPSSFHP 240 PNLSLLEAWV QRARRSRRTT LMMFAGGGGV GNNPNIRKSI RNECENNTIE NNVTSNNNNL 300 GMFGSGFAEY TRLCDFVDCS NGICEHDPIR FMRPMLQASF CMQPPGDTPT RRSTFDSIVA 360 GCIPVFFESL SAKVQYGWHL PEDQYGDFSV FIPKEDVVYK ETRVLDVLRS IPRARVRRMR 420 ERVLEMIPRV MYRRHGSSKG LRAKKDAFDL AIEGALKKIK SRVQVQPRGQ AFAQ 480 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 2.0e-50 | 48 | 411 | 372 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
RefSeq | NP_193989.1 | 0 | 42 | 463 | 31 | 435 | exostosin family protein [Arabidopsis thaliana] |
RefSeq | XP_002267390.1 | 0 | 47 | 464 | 32 | 439 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002304426.1 | 0 | 42 | 463 | 23 | 429 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002329867.1 | 0 | 11 | 466 | 5 | 435 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002529790.1 | 0 | 14 | 464 | 8 | 450 | catalytic, putative [Ricinus communis] |