Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000205654 |
Family | GT47 |
Protein Properties | Length: 547 Molecular Weight: 63575.5 Isoelectric Point: 10.2542 |
Chromosome | Chromosome/Scaffold: 018563236 Start: 7526 End: 10158 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 212 | 496 | 0 |
LKVYIYRDGERPIFHRPHLRGIYASEGWFMKLMEENRQFVTRDPEKAHLFYLPYSMRQLAMSLYVPNSHNLKPLSVFLREYANIIASKYPFWNRTHGSDH FLVACHDWGPYTLTAHEELTKNTIKALCNADTSEGIFVAGKDVSLPETTIRTPRKPLRNVGGLRVSQRPLLAFFAGNMHGRVRPTLLKYWRDKHDDMKIY GPLPLRVSRKMSYIQHMKSSKFCICPMGYEVNSPRIIESLYYECVPVIIADNFPPPLSDVIDWSTFSVIVAEKDIPKLREILMAI |
Full Sequence |
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Protein Sequence Length: 547 Download |
MKNLLESLAV ILMKEFFRLF AGHKIGWKKI FFXGAIMTAV CVMLQMFILA DPLDLWFLSL 60 PXEMPSXKLL NNSLRLNKTS TEAKIKRXQI FPRAPIVSPQ PSIELNLSVA IQPAALSVPP 120 QRKSPSRRRR KNARGDNIAK VTPPPPPPPY PKVPHRLQKF IWSLTPNEAL VYAKKEIEYA 180 PALTEDDPDL YAPIFRNVSV FKRSYELMEL ILKVYIYRDG ERPIFHRPHL RGIYASEGWF 240 MKLMEENRQF VTRDPEKAHL FYLPYSMRQL AMSLYVPNSH NLKPLSVFLR EYANIIASKY 300 PFWNRTHGSD HFLVACHDWG PYTLTAHEEL TKNTIKALCN ADTSEGIFVA GKDVSLPETT 360 IRTPRKPLRN VGGLRVSQRP LLAFFAGNMH GRVRPTLLKY WRDKHDDMKI YGPLPLRVSR 420 KMSYIQHMKS SKFCICPMGY EVNSPRIIES LYYECVPVII ADNFPPPLSD VIDWSTFSVI 480 VAEKDIPKLR EILMAIPMRR YLXMQINVKM VQKHFLWNPR PIRYDLFHMI LHSIWISRLS 540 QIQIPES |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 2.0e-65 | 212 | 496 | 301 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI23466.1 | 0 | 1 | 544 | 1 | 535 | unnamed protein product [Vitis vinifera] |
RefSeq | NP_567512.2 | 0 | 13 | 543 | 16 | 532 | exostosin family protein [Arabidopsis thaliana] |
RefSeq | XP_002269459.1 | 0 | 1 | 547 | 1 | 538 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002303362.1 | 0 | 162 | 547 | 1 | 386 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002530666.1 | 0 | 12 | 547 | 1 | 528 | catalytic, putative [Ricinus communis] |