| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000206538 |
| Family | GT47 |
| Protein Properties | Length: 378 Molecular Weight: 42654.6 Isoelectric Point: 9.4406 |
| Chromosome | Chromosome/Scaffold: 017080179 Start: 5283 End: 6905 |
| Description | Exostosin family protein |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GT47 | 65 | 344 | 5.6e-33 |
| NSLKVYVADLPRSLNYGLLEKYWASGPDSRLQTDIDHQIPDTHLPKNLEFPPYPENPLIKQYSAEYWILGDLMTPQEHRTGSFASRVFDAAEADVVFVPF FATLSAELQLXTARGVFRKKAGNEDYERQRQVVDFVKNTEAWKRSGGRDHVFVLTAVVIFEVCLFSWIPFDQLEVIRSTGKMLESNVVLKLEAFLADPVA MWHVRAEIAPAVLLVVDFGGWYRLESKSLNGNSSDVIQHTQVSLLKDVIVPYTHLLPRLQLTENKKRPTLLYFKGAKHRH | |||
| Full Sequence |
|---|
| Protein Sequence Length: 378 Download |
| MAVKSTATTT ASSSVCSVPT LFFAFTLLCA LSLSLFFLSN PSPSSSPPPS WSSFISQNAX 60 LSPQNSLKVY VADLPRSLNY GLLEKYWASG PDSRLQTDID HQIPDTHLPK NLEFPPYPEN 120 PLIKQYSAEY WILGDLMTPQ EHRTGSFASR VFDAAEADVV FVPFFATLSA ELQLXTARGV 180 FRKKAGNEDY ERQRQVVDFV KNTEAWKRSG GRDHVFVLTA VVIFEVCLFS WIPFDQLEVI 240 RSTGKMLESN VVLKLEAFLA DPVAMWHVRA EIAPAVLLVV DFGGWYRLES KSLNGNSSDV 300 IQHTQVSLLK DVIVPYTHLL PRLQLTENKK RPTLLYFKGA KHRHRLFGKL LKFHLTLFIC 360 PNALRTSHVN NRRGCRKV |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03016 | Exostosin | 1.0e-8 | 63 | 345 | 288 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| RefSeq | NP_564443.1 | 0 | 37 | 355 | 40 | 302 | exostosin family protein [Arabidopsis thaliana] |
| RefSeq | XP_002270238.1 | 0 | 1 | 345 | 1 | 300 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002325567.1 | 0 | 16 | 345 | 13 | 293 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002327326.1 | 0 | 31 | 345 | 1 | 266 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002533317.1 | 0 | 57 | 345 | 45 | 295 | catalytic, putative [Ricinus communis] |
