| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000207688 |
| Family | CBM57 |
| Protein Properties | Length: 1039 Molecular Weight: 115403 Isoelectric Point: 6.1472 |
| Chromosome | Chromosome/Scaffold: 017553482 Start: 35 End: 6175 |
| Description | Leucine-rich repeat transmembrane protein kinase |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| CBM57 | 238 | 416 | 3.6e-30 |
| SINCGGQQMKGDGILYETDESVLGSATFSVTSAENWAVSNAGLFSDQYPSSSPSSSRENTPSLVNTHAQVTGTDVTPELFQTSRVSTGSLRYYGLGLENG PYTVTLHFAETVYESRTSQTWQSLGRRVFDIYIQGTRRTKDFDISKEAGGVNRAVVRKFNVSMSENYLEIHLFWAGKGT | |||
| Full Sequence |
|---|
| Protein Sequence Length: 1039 Download |
| MGTHQLPYDF HSYMDSCGLG GEIPSTFAKL TNMQVFWASD SPFSGKIPDF IGNWTQLTDL 60 QFQGNSFEGP IPTSFSQLTS LNSLRISDIY NGSSSLDFIK NLKNLTELKL RNALITGTIP 120 SNIGEYQSLE TLDLSFNNLT GQLPSSLFNL SSLESLFLGN NSLSGPLLNQ KSDQLQTIDL 180 SYNFLSGSFP QWVTNISQVN LVVNNFTFDS SNITLRGLNC LQRNFPCNRN TPRYASFSIN 240 CGGQQMKGDG ILYETDESVL GSATFSVTSA ENWAVSNAGL FSDQYPSSSP SSSRENTPSL 300 VNTHAQVTGT DVTPELFQTS RVSTGSLRYY GLGLENGPYT VTLHFAETVY ESRTSQTWQS 360 LGRRVFDIYI QGTRRTKDFD ISKEAGGVNR AVVRKFNVSM SENYLEIHLF WAGKGTCCIP 420 DYGHYGPLIA AVHASSDFTK KSKAGLIVGI AVLVGVVSLL LIFAILFMRR KKTEKEDDED 480 ILGLGPWPYT FSYAELRAAT EDFNLSNKLG EGGYGPVYKG TLSDGRVVAV KQLSVASHQG 540 KSQFVSEIAT ISAVQHRNLV KLYGCCIEGS HHILVYEYLE NKSLDQALFG TSNLHLDWPT 600 RFNILLGTAR GLAYLHEESR PRIVHRDVKA SNILLDAELS PKISDFGLAK LYDDKKTHIS 660 TRVAGTIGYL APEYAXFGHL TEKADVFGFG VVVLEILSGR PNSYNNLDPE KIYLLEWVWT 720 LHENDQTXGL XDPRLXEFXE TEATRLIRAA LLCTXGSPMX RPSMSRVVAM LSGDIDISXV 780 MSKPSYLTXY XFKXVTTSLT SRFLVEDDTP STSSKGSNVR LNYQSGGSNA SARGLAYLHE 840 ESRPRIVHQD VKAINILLDA ELPPKISDFG LAKLYDGEKT HISTWVARTM XCIPLALFWH 900 CCEKLIHPFL GPWHNVFXTW TLHXNDQIXG LVDPRLTEFD ETEATRXIRX ALMCTXASPM 960 XRPXMSXVVA MLSXDIDXGT IXTKPSYLTY YDFKDXTTLS TXSFLMKDDT PSXXSKHSND 1020 XLNYEPEGNN TSGANTPRG |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| smart00221 | STYKc | 3.0e-9 | 832 | 878 | 48 | + Protein kinase; unclassified specificity. Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase. | ||
| smart00219 | TyrKc | 2.0e-9 | 832 | 878 | 48 | + Tyrosine kinase, catalytic domain. Phosphotransferases. Tyrosine-specific kinase subfamily. | ||
| smart00221 | STYKc | 5.0e-48 | 505 | 713 | 217 | + Protein kinase; unclassified specificity. Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase. | ||
| smart00219 | TyrKc | 4.0e-48 | 505 | 713 | 215 | + Tyrosine kinase, catalytic domain. Phosphotransferases. Tyrosine-specific kinase subfamily. | ||
| pfam11721 | Malectin | 1.0e-49 | 236 | 432 | 201 | + Di-glucose binding within endoplasmic reticulum. Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognises and binds Glc2-N-glycan. It carries a signal peptide from residues 1-26, a C-terminal transmembrane helix from residues 255-274, and a highly conserved central part of approximately 190 residues followed by an acidic, glutamate-rich region. Carbohydrate-binding is mediated by the four aromatic residues, Y67, Y89, Y116, and F117 and the aspartate at D186. NMR-based ligand-screening studies has shown binding of the protein to maltose and related oligosaccharides, on the basis of which the protein has been designated "malectin", and its endogenous ligand is found to be Glc2-high-mannose N-glycan. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0004672 | protein kinase activity |
| GO:0005515 | protein binding |
| GO:0005524 | ATP binding |
| GO:0006468 | protein phosphorylation |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI39026.1 | 0 | 13 | 815 | 206 | 1007 | unnamed protein product [Vitis vinifera] |
| EMBL | CBI39026.1 | 0.0000001 | 56 | 199 | 105 | 250 | unnamed protein product [Vitis vinifera] |
| EMBL | CBI39026.1 | 1.4013e-45 | 830 | 1016 | 803 | 1007 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002272404.1 | 0 | 13 | 815 | 161 | 964 | PREDICTED: hypothetical protein [Vitis vinifera] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3ulz_A | 0 | 491 | 774 | 20 | 309 | A Chain A, Crystal Structural Analysis Of Active Site Mutant Q189e Of Lgtc |
| PDB | 3ulz_A | 2e-19 | 830 | 975 | 139 | 309 | A Chain A, Crystal Structural Analysis Of Active Site Mutant Q189e Of Lgtc |
| PDB | 3uim_A | 0 | 491 | 774 | 20 | 309 | A Chain A, Structural Basis For The Impact Of Phosphorylation On Plant Receptor- Like Kinase Bak1 Activation |
| PDB | 3uim_A | 2e-19 | 830 | 975 | 139 | 309 | A Chain A, Structural Basis For The Impact Of Phosphorylation On Plant Receptor- Like Kinase Bak1 Activation |
| PDB | 3tl8_H | 0 | 491 | 774 | 28 | 317 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
