| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000208532 |
| Family | GH89 |
| Protein Properties | Length: 425 Molecular Weight: 48073.2 Isoelectric Point: 7.461 |
| Chromosome | Chromosome/Scaffold: 016178515 Start: 3473 End: 9713 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 230 | 421 | 0 |
| DFNISKEDLNDFFGGSAFLAWARMGNLHAWGGPLSQNWLDQQLVLQKQILSRMLELGMTPVLPSFSGNVPVTLKKVYPSANITRLGEWNTVDGDPRWCCT YLLDPSDPLFVEIGMAFVRRQVEEYGDVTDIYNCDTFNENTPPTNDTAYISSLGAAVYKAMSKGDKDAVWLMQGWLFYSDSAFWKPPQMKKV | |||
| Full Sequence |
|---|
| Protein Sequence Length: 425 Download |
| MSNFKIQLLI LIAVFIVPIL AVSAKAEAVT ALLRRLDSKR SSASVQEAAA KAVLERLLPT 60 HVHSFDFKIV SQDACGGHSC FMLNNYNLSS GHGPEIQVKG TTAVEIASGL HWYLKYWCGA 120 HVSWDKTGGA QLASIPSPGS LPRVRDEGLR IQRPVPWNYY QNVVTSSYSF VWWDWERWQK 180 EIDWMALQGI NLPLAFTGQE SIWQKVFMIY ILLTFLPYQK SRQCTYAKYD FNISKEDLND 240 FFGGSAFLAW ARMGNLHAWG GPLSQNWLDQ QLVLQKQILS RMLELGMTPV LPSFSGNVPV 300 TLKKVYPSAN ITRLGEWNTV DGDPRWCCTY LLDPSDPLFV EIGMAFVRRQ VEEYGDVTDI 360 YNCDTFNENT PPTNDTAYIS SLGAAVYKAM SKGDKDAVWL MQGWLFYSDS AFWKPPQMKK 420 VALLI |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 3.0e-25 | 46 | 144 | 99 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam05089 | NAGLU | 5.0e-124 | 159 | 424 | 266 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI24942.1 | 0 | 1 | 421 | 66 | 462 | unnamed protein product [Vitis vinifera] |
| GenBank | EEE59081.1 | 0 | 41 | 421 | 51 | 411 | hypothetical protein OsJ_10898 [Oryza sativa Japonica Group] |
| RefSeq | NP_196873.1 | 0 | 21 | 419 | 20 | 397 | alpha-N-acetylglucosaminidase family / NAGLU family [Arabidopsis thaliana] |
| RefSeq | XP_002273084.1 | 0 | 1 | 421 | 1 | 397 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002314048.1 | 0 | 24 | 421 | 24 | 401 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 6.99949e-42 | 65 | 404 | 190 | 492 | A Chain A, Crystal Structure At 1.45- Resolution Of The Major Allergen Endo-Beta-1,3-Glucanase Of Banana As A Molecular Basis For The Latex-Fruit Syndrome |
| PDB | 2vcb_A | 6.99949e-42 | 65 | 404 | 190 | 492 | A Chain A, Crystal Structure At 1.45- Resolution Of The Major Allergen Endo-Beta-1,3-Glucanase Of Banana As A Molecular Basis For The Latex-Fruit Syndrome |
| PDB | 2vca_A | 6.99949e-42 | 65 | 404 | 190 | 492 | A Chain A, Crystal Structure At 1.45- Resolution Of The Major Allergen Endo-Beta-1,3-Glucanase Of Banana As A Molecular Basis For The Latex-Fruit Syndrome |
| PDB | 2vc9_A | 6.99949e-42 | 65 | 404 | 190 | 492 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 1.99993e-41 | 65 | 404 | 213 | 515 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
