| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000220242 |
| Family | GH89 |
| Protein Properties | Length: 805 Molecular Weight: 91569.7 Isoelectric Point: 5.9385 |
| Chromosome | Chromosome/Scaffold: 021221287 Start: 47928 End: 52839 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 100 | 783 | 0 |
| PQILISGVTGVEILAGLHWYLKNLCNSHISWDKTGGAQLFSVPKSGLLTRVQDAGILVQRPVPWNYYQNAVTSSYTFAWWDWERWEKEIDWMALQGINLP LAFTGXEAIWQKVFQKFNMSKSDLDDFFGGPAFLAWSRMGNLHGWGGPLPQSWLDQQLILQKKILVRMYELGMTPVLPAFSGNVPAALKTTYPSAKITXL GNWFSVKSDPRWTCTYLLDATDPLFVEIGRAFIEQQVKGCDTFDENTPPDDAPEYISSLGAAIFRGMQSGDKXGVWLMQGWLFSYDPFWRPPQMKALLHS VPXGKLVVLDLFAEVKPIWSTTEQFYGNVEMYGVLDAXASGPIXARISENSTMVGVGMSMEGIEQNPVVYDLMSEMXFQHNKVDAKAWIDQYSARRYGRS TPSIQDAWNILYHTIYNCTDGAYXLLKQDKNRDVIVAFPDVDPSLISTLSEGRHQNEKPVAGSAVLKEVTDSFDRPHLWYSTSEVIHALELFIASGDELS ESSAYRYDLVDLTRQALSKYANQLFLKVIEAYHSNDVLGVARDSKKFLDLVEDMDXLLACHDGFLLGPWLESAKKLAQDXEQEKQFEWNARTQITMWFDN TEEEASLLRDYGNKYWSGLLRDYYGPRAAIYFKYLTKSLEEGGXFGLKDWRREWIKLTNDWQNSRKXFPVKSTGNAXNTSRWLF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 805 Download |
| MASKFPTFSP AFTILLTILF LDLAYSSTVG VRHISRLLEI QDREKAPPHV QVAAARGVLR 60 RLLPSHSSSF DFQIVSKEQC GGASCFMIKN NPSFRRRGDP QILISGVTGV EILAGLHWYL 120 KNLCNSHISW DKTGGAQLFS VPKSGLLTRV QDAGILVQRP VPWNYYQNAV TSSYTFAWWD 180 WERWEKEIDW MALQGINLPL AFTGXEAIWQ KVFQKFNMSK SDLDDFFGGP AFLAWSRMGN 240 LHGWGGPLPQ SWLDQQLILQ KKILVRMYEL GMTPVLPAFS GNVPAALKTT YPSAKITXLG 300 NWFSVKSDPR WTCTYLLDAT DPLFVEIGRA FIEQQVKGCD TFDENTPPDD APEYISSLGA 360 AIFRGMQSGD KXGVWLMQGW LFSYDPFWRP PQMKALLHSV PXGKLVVLDL FAEVKPIWST 420 TEQFYGNVEM YGVLDAXASG PIXARISENS TMVGVGMSME GIEQNPVVYD LMSEMXFQHN 480 KVDAKAWIDQ YSARRYGRST PSIQDAWNIL YHTIYNCTDG AYXLLKQDKN RDVIVAFPDV 540 DPSLISTLSE GRHQNEKPVA GSAVLKEVTD SFDRPHLWYS TSEVIHALEL FIASGDELSE 600 SSAYRYDLVD LTRQALSKYA NQLFLKVIEA YHSNDVLGVA RDSKKFLDLV EDMDXLLACH 660 DGFLLGPWLE SAKKLAQDXE QEKQFEWNAR TQITMWFDNT EEEASLLRDY GNKYWSGLLR 720 DYYGPRAAIY FKYLTKSLEE GGXFGLKDWR REWIKLTNDW QNSRKXFPVK STGNAXNTSR 780 WLFDKYLLXS ASDIQPLNEA AYPRL |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 4.0e-20 | 51 | 131 | 81 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 4.0e-98 | 486 | 786 | 301 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 2.0e-154 | 165 | 481 | 338 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI15090.1 | 0 | 24 | 787 | 21 | 838 | unnamed protein product [Vitis vinifera] |
| GenBank | EEC78143.1 | 0 | 33 | 796 | 32 | 815 | hypothetical protein OsI_17702 [Oryza sativa Indica Group] |
| RefSeq | XP_002280399.1 | 0 | 24 | 787 | 21 | 805 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002318632.1 | 0 | 26 | 787 | 26 | 804 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002511461.1 | 0 | 10 | 787 | 6 | 800 | alpha-n-acetylglucosaminidase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 43 | 800 | 167 | 891 | A Chain A, Pectin Methylesterase From Yersinia Enterocolitica |
| PDB | 2vcb_A | 0 | 43 | 800 | 167 | 891 | A Chain A, Pectin Methylesterase From Yersinia Enterocolitica |
| PDB | 2vca_A | 0 | 43 | 800 | 167 | 891 | A Chain A, Pectin Methylesterase From Yersinia Enterocolitica |
| PDB | 2vc9_A | 0 | 43 | 800 | 167 | 891 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 43 | 800 | 190 | 914 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
