| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000223942 |
| Family | GT47 |
| Protein Properties | Length: 530 Molecular Weight: 59799.6 Isoelectric Point: 8.3032 |
| Chromosome | Chromosome/Scaffold: 02201484 Start: 772 End: 3798 |
| Description | Exostosin family protein |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GT47 | 136 | 448 | 0 |
| PVKVYLYDLPKRFTYGVIEHHSLARGGRPDDDVSKLKYPGHQHMGEWYLFQDLLKPESERVGSPVERALDPEEADLFYVPFFSSLSLIVNPARPASGSEK PLYSDEENQVALIEWLESQEYWKRNXGRDHVIMASDPNALYKVINKVKNCVLLVCDFGRLKEDQGSLVKDVIVPYSHRINTYTGDISVENRNALLFFMGN RFRKDGGKIRDLLFQLLENEEDVIVKHGTQSRESRRAATHGMHTSKFCLNPAGDTPSACRLFDSIVSLCVPVIISDSIELPFEDVIDYRKIAIFVESNAA LKPGFLVSMLRGI | |||
| Full Sequence |
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| Protein Sequence Length: 530 Download |
| MISYQRNQPV PQYTTTLAHV SRAHRXPKTT GMMSSELQSS KANKPSAPSS TSLDXLHRKT 60 LTQFLSMARK SSLLKQSLAT IVGVLVLYAF LNTFLTPAAT SKLENAFPSF SSVASNSISS 120 DVFATLENQL NLPGKPVKVY LYDLPKRFTY GVIEHHSLAR GGRPDDDVSK LKYPGHQHMG 180 EWYLFQDLLK PESERVGSPV ERALDPEEAD LFYVPFFSSL SLIVNPARPA SGSEKPLYSD 240 EENQVALIEW LESQEYWKRN XGRDHVIMAS DPNALYKVIN KVKNCVLLVC DFGRLKEDQG 300 SLVKDVIVPY SHRINTYTGD ISVENRNALL FFMGNRFRKD GGKIRDLLFQ LLENEEDVIV 360 KHGTQSRESR RAATHGMHTS KFCLNPAGDT PSACRLFDSI VSLCVPVIIS DSIELPFEDV 420 IDYRKIAIFV ESNAALKPGF LVSMLRGIPT ERILEYQTEL NEHCKEAKVK HYFQYGEPNG 480 TVNEIWRQIA QKLPFIKLTI NRERRLVKRD SNVLDCSCLC SNQTGIITSL |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03016 | Exostosin | 2.0e-77 | 133 | 448 | 327 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| RefSeq | NP_850241.1 | 0 | 67 | 530 | 1 | 447 | ARAD1 (ARABINAN DEFICIENT 1); catalytic/ transferase, transferring glycosyl groups [Arabidopsis thaliana] |
| RefSeq | XP_002276440.1 | 0 | 40 | 530 | 7 | 494 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002318294.1 | 0 | 141 | 530 | 1 | 382 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002322391.1 | 0 | 67 | 530 | 1 | 457 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002523645.1 | 0 | 67 | 530 | 1 | 452 | catalytic, putative [Ricinus communis] |
