Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000232295 |
Family | AA3 |
Protein Properties | Length: 506 Molecular Weight: 55225.9 Isoelectric Point: 5.3596 |
Chromosome | Chromosome/Scaffold: 008178461 Start: 35871 End: 37604 |
Description | Glucose-methanol-choline (GMC) oxidoreductase family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
AA3 | 20 | 494 | 0 |
EASGKSFDYIVIGGGTAGCPLAATLSEKFSVLLVERGGSPYGDPLVLDTKYYGFSLLRTDQYTSVAQXFVSNDGVRNLRGRVLGGGSAINGGFYSRASED FVEKVGWDKEMVTNAYQWVESRIVFKPELTPWQYAAEFSFLEAGVFPYNGFSXDHIEGTKIGASVFDEQGRRHTSADLLEAGNPNHITVLLNATVTNVIF HERGDRNETXARGIRFIKSNGNSSEIYEAHLNQPENSCSGGDVILAAGALGSPQILLLSGIGPHQHLNNFNIQLVLDLEAVGKGMKDNPGIALLADPTPK NFPPEPPKVVGIADDFKIIIEAGILPVSSNATIMPIAAKLAFPESEGKLELNSTDPRENPSVTFNYLAKEKDLAQCLKLAQLLERVVRSESIAFFLGIER KPKDKLMSTEDELRKLCTKNVITFFHYHGGCTMGSVVDKDYRVYGVKGLRVVDGSTFFESPGTNPMATLLMLGRY |
Full Sequence |
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Protein Sequence Length: 506 Download |
MSVFEIAGQT LPHITSDVNE ASGKSFDYIV IGGGTAGCPL AATLSEKFSV LLVERGGSPY 60 GDPLVLDTKY YGFSLLRTDQ YTSVAQXFVS NDGVRNLRGR VLGGGSAING GFYSRASEDF 120 VEKVGWDKEM VTNAYQWVES RIVFKPELTP WQYAAEFSFL EAGVFPYNGF SXDHIEGTKI 180 GASVFDEQGR RHTSADLLEA GNPNHITVLL NATVTNVIFH ERGDRNETXA RGIRFIKSNG 240 NSSEIYEAHL NQPENSCSGG DVILAAGALG SPQILLLSGI GPHQHLNNFN IQLVLDLEAV 300 GKGMKDNPGI ALLADPTPKN FPPEPPKVVG IADDFKIIIE AGILPVSSNA TIMPIAAKLA 360 FPESEGKLEL NSTDPRENPS VTFNYLAKEK DLAQCLKLAQ LLERVVRSES IAFFLGIERK 420 PKDKLMSTED ELRKLCTKNV ITFFHYHGGC TMGSVVDKDY RVYGVKGLRV VDGSTFFESP 480 GTNPMATLLM LGRYQGMKVL QERENA |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam05199 | GMC_oxred_C | 5.0e-32 | 362 | 492 | 136 | + GMC oxidoreductase. This domain found associated with pfam00732. | ||
TIGR01810 | betA | 1.0e-37 | 27 | 492 | 559 | + choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli , Staphylococcus xylosus , and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified [Cellular processes, Adaptations to atypical conditions]. | ||
PRK02106 | PRK02106 | 7.0e-42 | 24 | 492 | 580 | + choline dehydrogenase; Validated | ||
COG2303 | BetA | 2.0e-42 | 21 | 493 | 546 | + Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism] | ||
PLN02785 | PLN02785 | 2.0e-158 | 25 | 503 | 538 | + Protein HOTHEAD |
Gene Ontology | |
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GO Term | Description |
GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors |
GO:0050660 | flavin adenine dinucleotide binding |
GO:0055114 | oxidation-reduction process |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
RefSeq | NP_563939.1 | 0 | 8 | 503 | 19 | 503 | glucose-methanol-choline (GMC) oxidoreductase family protein [Arabidopsis thaliana] |
RefSeq | XP_002312249.1 | 0 | 14 | 502 | 1 | 486 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002315047.1 | 0 | 8 | 502 | 1 | 489 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002315048.1 | 0 | 8 | 506 | 32 | 529 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002522448.1 | 0 | 6 | 506 | 30 | 528 | glucose-methanol-choline (gmc) oxidoreductase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3gdp_B | 0 | 25 | 503 | 26 | 517 | A Chain A, Crystal Structure Of The Polygalacturonase From Colletotrichum Lupini And Its Implications For The Interaction With Polygalacturonase- Inhibiting Proteins |
PDB | 3gdp_A | 0 | 25 | 503 | 26 | 517 | A Chain A, Crystal Structure Of The Polygalacturonase From Colletotrichum Lupini And Its Implications For The Interaction With Polygalacturonase- Inhibiting Proteins |
PDB | 3gdn_B | 0 | 25 | 503 | 26 | 517 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
PDB | 3gdn_A | 0 | 25 | 503 | 26 | 517 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
PDB | 1ju2_B | 0 | 25 | 504 | 26 | 518 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
GO527356 | 208 | 128 | 335 | 0 |
JZ191231 | 271 | 17 | 286 | 0 |
HO796743 | 536 | 27 | 503 | 0 |
JZ194700 | 272 | 11 | 281 | 0 |
JZ191217 | 249 | 9 | 256 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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